Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Abstract

BackgroundABO blood group is a hereditary factor of plasma levels of coagulation factor VIII (FVIII) and von Willebrand factor (VWF). Age and gender have been shown to influence FVIII, VWF, fibrinogen (Fbg), and ADAMTS13 (A disintegrin and metalloprotease with thrombospondin type 1 motif, 13). We investigated the effects of ABO type, age, and gender on plasma levels of FVIII, Fbg, VWF, and ADAMTS13 in a Chinese population.MethodsA total of 290 healthy volunteers were eligible for this study. ABO blood group was determined by indirect technique. FVIII:C and Fbg were measured by clotting assays. VWF antigen (VWF:Ag), collagen-binding activity (VWF:CBA), and ADAMTS13 antigen were assessed by ELISA, whereas VWF ristocetin cofactor activity (VWF:Rcof) was performed by agglutination of platelets with ristocetin.ResultsMean FVIII:C and VWF levels (VWF:Ag, VWF:CBA, and VWF:Rcof) were significantly higher in non-O than in O type subjects (p < 0.05 for all comparison). ADAMTS13 antigen decreased with increasing age, whereas the other parameters increased. Other than ADAMTS13 (p < 0.01), no gender-related variations were observed in the other parameters. Moreover, FVIII:C, Fbg, VWF:Ag, VWF:CBA, and VWF:Rcof showed significant and positive relationships with age (r = 0.421, 0.445, 0.410, 0.401, and 0.589, resp.; all p < 0.001), whereas a negative relationship was observed for ADAMTS13 antigen (r = 0.306; p = 0.006). Furthermore, FVIII:C were strongly correlated with VWF:Ag, VWF:CBA, and VWF:Rcof (r = 0.746, r = 0.746, and r = 0.576, resp.; p < 0.0001). VWF parameters were also strongly correlated with each other (r = 0.0.847 for VWF:Ag and VWF:CBA; r = 0.722 for VWF:Ag and VWF:Rcof; p < 0.0001).ConclusionsABO blood group, age, and gender showed different effects on plasma levels of FVIII:C, Fbg, VWF:Ag, VWF:CBA, VWF:Rcof, and ADAMTS13 antigen. These new data on a Chinese population are quite helpful to compare with other ethnic groups.

The quality changes in fresh frozen plasma of the blood donors at high altitude

“…Furthermore, numerous studies generally reported that plasma vWF and FVIII levels were significantly lower in O-group than non-O-group individuals [ 19 – 21 ].Similarly, our study showed vWF: Ag and FVIII:C were significantly lower in O-group than in non-O-group in HA blood donors ( p< 0.05). In another large-scale study on LA blood donors, we also found the levels of vWF and FVIII were significantly lower in O-group than non-O-group [ 22 ]. This could also provide reference for FFP preparation.…”

Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy

“…The reason why the effects of the ADAMTS13 SNP on the survival outcomes were not found in the female recipients is unknown. A recent study [25] has reported that blood levels of ADAMTS13 antigens were higher in females than in males, which may suggest that female recipients have a greater amount of ADAMTS13 antigen in the blood and are less likely to be affected by the ADAMTS13 SNP than male recipients, although this is highly speculative. Further studies will be needed to clarify whether the ADAMTS13 antigen can effectively protect transplant recipients against relapse.…”

Plasma proteomic and autoantibody profiles reveal the proteomic characteristics involved in longevity families in Bama, China

“…And also 33 ABO-, age- and gender-matched offsprings of non-longevity families were recruited as controls (Normal group). The inclusion criteria of the participators were recruited as previously described and apheresis plasma of the participators was used in this study [27]. Briefly, all participators were over 18 years of age, healthy and unrelated.…”