Fresh-frozen human bone graft to repair defect after mandibular giant follicular cyst removal: a case report

Abstract

The purpose of this article is to report the clinical, radiographical and histological findings about a case of a young woman affected by a mandibular giant follicular cyst. Conservative tumor resection was followed by immediate reconstructive treatment using fresh frozen human bone graft, instead of autologous bone graft, as material for bone regeneration. Follicular cyst is a benign, non invasive lesion with slow but progressive growth. Radiological and histological examination of the lesion confirmed the presence of a follicular cyst which underwent biopsy evaluation before enucleation. According to literature, conservative treatment was performed with optimal prognosis. At 24 months post surgery no evidence of recurrency was objective; the CT scan revealed optimal bone formation inside the reconstructed site. The use of fresh frozen bone allograft, thanks to its osteoinductive and osteoconductive properties, can be a safe choice for reconstruction of bone defects after jaw cysts removal.

Histomorphometrical Evaluation of Fresh Frozen Bone Allografts for Alveolar Bone Reconstruction: Preliminary Cases Comparing Femoral Head with Iliac Crest Grafts

“…8,13,14,17,18 The results were supported by observations showing the osteoinductive and osteoconductive properties of FFB 17,19 and the preservation of bone morphogenetic proteins. Some literature data reported that FFB could be used alone or in combination with autologous bone graft for alveolar bone reconstruction and for large mandibular reconstructions after the resection of a large portion of the mandible for the complete removal of cysts and tumors.…”

Maxillary sinus grafting with autograft vs. fresh frozen allograft: a split‐mouth histomorphometric study

“…The absence of negative reports concerning its antigenicity and reduced immunologic reaction in experimental models suggests that FFB could represent an adequate alternative to AB (Okada et al1990;Stevenson et al 1997 studies about the effect of FFB in oral and maxillofacial surgery are scarce. Some literature data reported that FFB could be used alone or in combination with AB for the reconstruction of atrophic alveolar bone or large mandibular defects (Perrott et al1992;D'Aloja et al 2008D'Aloja et al , 2011Franco et al 2009;de Macedo et al 2009;Orsini et al 2011;Acocella et al 2012;Albanese et al 2012). The results were supported by observations showing the osteoinductive and osteoconductive properties of FFB (Perrott et al 1992;Shand et al 2002) and the preservation of bone morphogenetic proteins (Rodella et al 2010).…”

“…; Albanese et al. ). The results were supported by observations showing the osteoinductive and osteoconductive properties of FFB (Perrott et al.…”

An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs)

“…Among various sources of mesenchymal stem cells, dental pulp is a promising source of osteoprogenitor cells for regenerative medicine [6,7]. Human dental pulp stem cells (hDPSCs) were found to be multipotent with a high osteogenic potential compared to bone marrow mesenchymal stem cells (BMSCs) [8,9].…”

“…The resorption rates of synthetic bone-graft materials depend on the surface area, physical properties, and chemical composition [6]. Calcium sulfate, β-tricalcium phosphate (β-TCP), and hydroxyapatite are typical commercial bone grafts, which exhibit respective resorption periods of 1-2, 6-12, and 12-36 months, respectively [14,16].…”