Frequent seizures and polytherapy can impair quality of life in persons with epilepsy

Thomas, Sanjeev V; Koshy, Samuel; Nair, CP Reghunadhan; Sarma, Sankara P.

doi:10.4103/0028-3886.15054

Cited by 84 publications

(98 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The differences were highly statistically significant on ANOVA (p value<0.001).This shows that education improves quality of life. Similar results were reported by Choi-Kwon S et al 11 Frequency of seizures per month was positively correlated with QOLIE-9 total scores (Pearson Correlation 0.622) and was highly statistically significant (p value <0.001), as also reported by Djibuti et al and Thomas et al 2,10 Duration of illness positively correlated with QOLIE-9 total scores (Pearson Correlation 0.118) and but was statistically insignificant (p value 0.242). Szaflarski et al found poor quality of life with increase duration of illness.…”

Section: Discussionsupporting

confidence: 78%

“…2,6 Most of the previous studies on this topic were also carried out in large epilepsy centres. 5,7 Breier et al compared self-reported quality of life in patients with intractable epilepsy and pseudo seizures.…”

Section: Discussionmentioning

confidence: 99%

“…QOL is influenced by biological factors as well as cultural, social and religious beliefs and values. 2 Many factors influence the quality of life of people with epilepsy, including seizure severity, stigma, fear, and the presence of cognitive or psychiatric problems. 3 Dodrill et al suggested that seizures may be only one of several variables that impact the psychosocial functioning of patients with epilepsy.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Quality of life in epilepsy

Singh¹,

Pandey

2017

Int J Res Med Sci

View full text Add to dashboard Cite

Background: The quality of life (QOL) evaluation is a relatively new measure to evaluate the outcome of epilepsy. Many factors influence the quality of life of people with epilepsy, including seizure severity, stigma, fear, and the presence of cognitive or psychiatric problems. QOL is influenced by biological factors as well as cultural, social and religious beliefs and values. This study was planned to find out the impact of epilepsy on quality of life of epileptic patients.Methods: The study was conducted in the epilepsy clinic of department of neurology at a tertiary care hospital over a period of one year.101 patients were included after fulfilling the inclusion criteria. All the patients seeking treatment in the OPD were screened, assessed and then all procedures were fully explained to them. History regarding name, age sex, socio-demographic profile and detailed history regarding seizure disorder was taken from both the patient and the reliable informant. Bengali version of QOLIE-9 was used to assess the quality of life.Results: One hundred and one patients with epilepsy consisting of 70 men (69.3%) and 31 women (30.7%) were included. Their ages ranged from 15 to 52, the mean age being 26.17 (SD = 7.84). Out of the 101 patients, 65 patients (64.4%) were suffering from partial epilepsies and 36 patients (35.6%) were suffering from generalized epilepsies. Mean QOLIE-9 total scores were 16.66, 19.74, 20.13 and 24.00 in married, widows, unmarried and separated individuals respectively. The differences in the means were statistically significant on ANOVA (p value 0.002). Mean QOLIE-9 total scores were 27.75, 19.64, 19.65, 18.14 and 18.00 in primary, secondary, higher secondary, graduate and postgraduate individuals respectively. The differences were highly significant statistically on ANOVA (p value<0.001). Frequency of seizures per month was positively correlated with QOLIE-9 total scores (Pearson Correlation 0.622) and was highly statistically significant (p value<0.001).Conclusions: Frequent seizures, lower education level and single status are associated with lower quality of life in persons with epilepsy.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Quality of life in epilepsy

Singh¹,

Pandey

2017

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Многие авторы отмечают, что при применении в качестве доба-вочной терапии ПЭП последнего поколения, отмечается лучший профиль переносимости политерапии [77,78]. Следует отметить, что есть и другие данные: согласно ис-следованиям, проведенным в разных странах [79][80][81] у больных эпилепсией, получавших политерапию, отмеча-лись более низкие показатели качества жизни (КЖ), а при переводе с политерапии на монотерапию показатели КЖ улучшались [78,82,83].…”

Section: вероятность эффективности терапии при первой неудачеunclassified

Algorithms of mono- and polytherapy in clinical epileptology

Карлов

Guekht

Guzeva

et al. 2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

“…Even when the seizures cannot be controlled completely, a reduction in their frequency and severity can contribute immensely to enhancing the patient's quality of life and general wellbeing [10] [11] [12]. The rational use of antiepileptic drugs in settings with limited resources necessitate the evaluation and audit of their prescribing patterns in relation to efficacy in seizure control and patient wellbeing enhancement [11] [13]. The assessment and monitoring of care quality is necessary for health system capacity-building, decision-making and policy actions [13] [14].…”

Section: Introductionmentioning

confidence: 99%

Anti-Epileptic Drug Prescription in a Psychiatric Hospital Outpatient Clinic in Southeast Nigeria

Achor¹,

Nwefoh²,

Ezeala-Adikaibe³

et al. 2017

OJPsych

View full text Add to dashboard Cite

The optimum control of seizures requires adequate dosing of appropriately selected anti-epileptic medications. The availability of AEDs in Nigeria is limited and this constrains the prescription latitude of clinicians. This study was conducted to describe the prescribing pattern of anti-epileptic drugs in the outpatient service of a psychiatric facility in southeast Nigeria. The case records of the epileptic patients attending the outpatient clinic of a psychiatric hospital were retrieved, reviewed and data abstracted with a prepared proforma. The information extracted include age, sex, marital status, residence, type of seizure and anti-seizure medications prescribed, frequency of administration and dosage among other variables. Of the 178 patients whose prescriptions and case records were assessed, males constituted 62.9% and females 37.1%. Most of the patients were single (78.1%) and the group had a mean age of 25.6 ± 10.9 years. Generalized tonic-clonic seizures predominated (61.2%) among the seizure types, whilst complex partial seizure type was identified in 35.4% of the patients. Patient diagnosis relied heavily on the use of clinical description alone. About 92.7% of the patients were treated with monotherapy, whereas 7.3% received two anti-epileptic drug combinations. Carbamazepine was the most frequently prescribed drug, and was utilized in the treatment of 87.9% of patients receiving monotherapy and 92.3% of individuals receiving two drug combinations. Adjunctive medications like benzodiazepines were rarely utilised to improve the effect of the AEDs. The patients that received polytherapy could only be distinguished from those that received 295 Open Journal of Psychiatry monotherapy by higher frequency of epileptic auras and higher mean dose of AEDs per day. The predominant use of monotherapy is in accordance with the treatment recommendations and needs to be encouraged. The greater use of carbamazepine is probably related to its perceived benefits in the control of behavioural symptoms.

show abstract

Frequent seizures and polytherapy can impair quality of life in persons with epilepsy

Abstract: Frequent seizures and polytherapy are associated with lower QOL in persons with epilepsy.

Cited by 84 publications

References 17 publications

Quality of life in epilepsy

Quality of life in epilepsy

Algorithms of mono- and polytherapy in clinical epileptology

Anti-Epileptic Drug Prescription in a Psychiatric Hospital Outpatient Clinic in Southeast Nigeria

Contact Info

Product

Resources

About