Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population

Lévy, J; Ferro, Frank; Greenspan, D.; Lennette, Evelyne T.

doi:10.1016/0140-6736(90)92628-u

Cited by 306 publications

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“…HHV-6 persists in the cervical lymphnodes of normal adults as well as patients with necrotizing lymphoadenitis (7) and it is reactivated in immunosuppressed renal transplant recipients (22). HHV-6 has been recovered from the saliva of healthy adults (9,15,23). In fact, HHV-6 genomes are detectable by polymerase chain reaction in throat swabs of asymptomatic individuals (8,11).…”

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confidence: 98%

Seroprevalence of Human Herpesvirus 6 Infection in Brazilian and Japanese Populations in the North‐East of Brazil

Linhares

Eizuru

Tateno

et al. 1991

Microbiology and Immunology

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The seroprevalence of human herpesvirus 6 (HHV-6) infection was examined for 434 Brazilians and 250 Japanese immigrants living in Recife and its vicinity, in the North-East of Brazil.A total of 684 sera from the healthy individuals were screened for IgG antibodies to HHV-6 by anticomplement immunofluorescence (ACIF) test. The seropositivity rate to HHV-6 showed little difference between the two groups: namely, it was 76.5% for Brazilians and 77.2% for Japanese immigrants. The seropositivity rate was constantly higher in females than in males. The high prevalence of anti-HHV-6antibodies among children indicates that HHV-6 infection occurs very early in life.

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confidence: 98%

Seroprevalence of Human Herpesvirus 6 Infection in Brazilian and Japanese Populations in the North‐East of Brazil

Linhares

Eizuru

Tateno

et al. 1991

Microbiology and Immunology

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“…HHV-6 has since been isolated from the peripheral blood of HIV-infected individuals in Uganda (strain U1102) (Downing et al, 1987), The Gambia (strain A J) (Tedder et al, 1987) and Zaire (strain Z29) (Lopez et al, 1988). The virus has also been recovered from the saliva of healthy adults (Pietroboni et al, 1988;Harnett et al, 1990;Levy et al, 1990) and from the peripheral blood of individuals immunocompromised following organ transplantation (Ward et al, 1989).…”

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confidence: 99%

The Genome of Human Herpesvirus 6: Maps of Unit-length and Concatemeric Genomes for Nine Restriction Endonucleases

Martin

Thomson

Honess

et al. 1991

Journal of General Virology

111

101

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“…4 The seroprevalence increases to 65% by 1 year of age 6 and to greater than 90% by 13 to 36 months of age. 4,6,7 Accumulating clinical and laboratory evidence suggests that HHV-6, like all other herpesviruses, may have neurotropic properties. RI may be complicated by seizures, encephalopathy, aseptic meningitis, meningoencephalitis, and hemiplegia.…”

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“…24 Reports of the prevalence of febrile seizures complicating RI have varied considerably from 1% to 50%. 7,[25][26][27] The wide variation in the reported prevalence of febrile seizures complicating RI relates probably to the methodologic differences between studies.HHV-6 may play a causative role in febrile seizures, based on the high incidence of febrile seizures complicating RI, the neurotropic properties of this virus, and the similarity of age group in which febrile seizures and HHV-6 infection occur. Most previous reports on HHV-6 infection and febrile convulsions have been retrospective or have involved only small patient numbers.…”

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Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures

Hukin

Farrell²,

MacWilliam

et al. 1998

PEDIATRICS

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ABSTRACT. Rationale. Human herpesvirus 6 (HHV-6) has been demonstrated to be the causative agent in roseola infantum. It has been suggested that HHV-6 may have neurotropic properties and be involved in the pathogenesis of febrile seizures in infants. We describe a case-control study to examine the hypothesis that acute HHV-6 infection occurs more commonly in children with febrile seizures than in controls.Methods. Patients presenting with a first or second febrile seizure between 6 months and 2 years of age were entered in the study. Control patients did not have a seizure but had similar inclusion and exclusion criteria. Specimens were obtained for HHV-6 viral serology and polymerase chain reaction in the acute stage and approximately 2 weeks later. A diagnosis of HHV-6 infection was based on HHV-6-specific IgM and IgG serology and HHV-6 polymerase chain reaction of peripheral blood mononuclear cells and saliva.Results. Eighty-six patients (45 with febrile seizures; 41 controls) were enrolled. The HHV-6 infection status could be determined in only 68 patients (35 with febrile seizures; 33 controls). Acute HHV-6 infection was identified in 15 of 35 febrile seizure patients and in 15 of 33 controls. Evidence of past HHV-6 infection was demonstrated in 13 febrile seizure patients and in 8 controls.Conclusions. The incidence of primary HHV-6 infection is similar in patients with febrile seizures and agematched controls. HHV-6 does not seem to be a major factor in the pathogenesis of first and second febrile seizures. Pediatrics 1998;101(2). URL: http://www. pediatrics.org/cgi/content/full/101/2/e3; human herpesvirus 6, febrile seizures, case-control.ABBREVIATIONS. HHV-6, human herpesvirus 6; RI, roseola infantum; CSF, cerebrospinal fluid; PCR, polymerase chain reaction; PBMN, peripheral blood mononuclear cells; HSV, herpes simplex virus; CMV, cytomegalovirus; EBV, Epstein-Barr virus; ELISA, enzyme-linked immunosorbent assay; IFA, immunofluorescent assay. H uman herpesvirus 6 (HHV-6), a lymphotropic virus, is the causative agent of roseola infantum (RI).1,2 HHV-6 infection is more often associated with a nonspecific febrile illness between 6 months and 2 years of life.3 Seroprevalence studies in Japan, England, and the United States demonstrate that infection with HHV-6 is common.4 -6 HHV-6-specific IgG can be detected in almost all newborns, but the prevalence declines to less than 10% by 4 to 5 months of age, presumably as maternal antibody wanes. 4 The seroprevalence increases to 65% by 1 year of age 6 and to greater than 90% by 13 to 36 months of age. 4,6,7 Accumulating clinical and laboratory evidence suggests that HHV-6, like all other herpesviruses, may have neurotropic properties. RI may be complicated by seizures, encephalopathy, aseptic meningitis, meningoencephalitis, and hemiplegia. Febrile seizures are the commonest cause of seizures in early childhood and present before 3 years of age in more than 80% of patients. 21,22 A family history of seizures, usually febrile seizures, is observed in 30% to 50% o...

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Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population

Cited by 306 publications

References 0 publications

Seroprevalence of Human Herpesvirus 6 Infection in Brazilian and Japanese Populations in the North‐East of Brazil

Seroprevalence of Human Herpesvirus 6 Infection in Brazilian and Japanese Populations in the North‐East of Brazil

The Genome of Human Herpesvirus 6: Maps of Unit-length and Concatemeric Genomes for Nine Restriction Endonucleases

Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures

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