Frequency of virulence factors in Helicobacter pylori-infected patients with gastritis

Salimzadeh, Loghman; Bagheri, Nader; Zamanzad, Behnam; Azadegan‐Dehkordi, Fatemeh; Rahimian, Ghorbanali; Chaleshtori, Morteza Hashemzadeh; Rafieian-Kopaei, Mahmoud; Sanei, Mohammad Hossein; Shirzad, Hedayatollah

doi:10.1016/j.micpath.2015.01.008

Cited by 47 publications

(29 citation statements)

References 30 publications

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“…In Iran, Salimzadeh et al . found that H. pylori strains with cag A, vac As1, and oip A positivity were associated with a more severe gastritis as assessed by histologic features including neutrophil activity and chronic inflammation, but virulence factors did not appear to determine the overall pattern of gastritis among 436 dyspeptic patients undergoing gastroduodenoscopy.…”

Section: Prevalence Of Virulence Factors and Associations With Clinicmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

2016

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This review of recent publications related to the epidemiology of Helicobacter pylori highlights the origin of the infection, its changing prevalence, transmission, and outcome. A number of studies have addressed the ancestor roots of the bacteria, and the first genomewide analysis of bacterial strains suggests that its coexistence with humans is more ancient than previously thought. As opposed to the generally declining prevalence of H. pylori (including China and Japan), in Sweden, the prevalence of atrophic gastritis in the young population has risen. The prevalence of the infection remains high in the indigenous populations of the Arctic regions, and reinfection rates are high. A high prevalence is permanently found in the Siberian regions of Russia as well. Several studies, some of which used multiplex serology, addressed prevalence of and risks associated with various H. pylori serotypes, thereby enabling more precise risk assessment. Transmission of H. pylori was discussed, specifically fecal-oral transmission and the use of well-water and other unpurified water. Finally, the long-term course of H. pylori infection was considered, with an estimated 89% of noncardia gastric cancer cases being attributable to the infection.

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Section: Prevalence Of Virulence Factors and Associations With Clinicmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

2016

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“…It is recognized as a major cause of gastritis, peptic ulcer, gastric carcinoma and mucosa‐associated lymphoid tissue lymphoma . Its unique ability to survive under acidic conditions, high motility and ability to release cytotoxins are considered the main virulence factors . Furthermore, H. pylori is claimed to contribute to development of various extra‐gastric disorders, including neurodegenerative and hematologic disorders, cardiovascular conditions, insulin resistance and autoimmune syndromes .…”

Section: Introductionmentioning

confidence: 99%

Molecular diagnosis of Helicobacter pylori antibiotic resistance in the Taif region, Saudi Arabia

Eed

Hawash

Khalifa

et al. 2019

Microbiology and Immunology

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Success in eradication of Helicobacter pylori is declining globally because H. pylori has developed resistance against most of the antibiotics proposed for eradication regimens, mainly through point mutations. The present study included 200 patients with dyspepsia attending Taif Hospital. Gastric biopsies were obtained during gastroscopy and subjected to rapid urease testing. Molecular methods were used to confirm diagnoses of H. pylori infection and to identify resistance gene variants of four antibiotics; namely, clarithromycin, metronidazole, fluoroquinolones and tetracycline (23S rRNA, gyrA, rdxA and 16S rRNA respectively). Of all investigated patients, Molecular diagnoses were made in 143 of all investigated patients; thus, the prevalence was .5%. The overall rate of resistance to clarithromycin among the H. pylori‐positive patients was high (39.9%) and the rate of resistance significantly greater (48.2%) among the secondary resistance group, secondary resistance being defined as resistance as a result of previous exposure to the relevant antibiotic. The rate of resistance to fluoroquinolones was considered moderate; the difference in rate of resistance between the primary and secondary resistance groups (8.4% and 9.5%, respectively) was not significant Also, there was a low prevalence of both primary and the secondary tetracycline resistance in the study cohort. In contrast, the prevalence of metronidazole resistance was considered high with no significant difference between the two resistance groups. H. pylori showed an increased prevalence of resistance to all four of the commonly used therapeutic agents. Thus, eradication therapy should be based on the regional results of susceptibility testing. Moreover, treatment tailored according to individually determined H. pylori susceptibility may be a reasonable future goal.

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“…Virulent factors such as vacuolating cytotoxin A (VacA), cytotoxin‐associated protein A (CagA), adhesins, flagella, urease, and heat shock proteins are associated with the pathogenesis of H. pylori infection . Especially, CagA is important for mediating receptor–ligand recognition during the initial interaction between H. pylori and host cells that results in cancer development .…”

Section: Introductionmentioning

confidence: 99%