Epidemiology of <i>Helicobacter pylori</i> infection

Pérez-Pérez, Guillermo I.; Rothenbacher, Dietrich; Brenner, Hermann

doi:10.1111/hel.12332

Cited by 337 publications

(66 citation statements)

References 38 publications

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“…It is estimated that H. pylori infects half the world population [11, 32, 33] and is responsible for more than 60% of gastric cancer cases [34, 35]. In this series the prevalence of H. pylori for both groups, patients with carcinoma and controls, fall within the described in the literature.…”

Section: Discussionmentioning

confidence: 62%

Prevalence and characteristics of Epstein–Barr virus-associated gastric carcinomas in Portugal

Nogueira

Mota

Gradiz

et al. 2017

Infect Agents Cancer

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BackgroundGastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein–Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population.MethodsIn the present study, we have analyzed 82 gastric carcinoma cases and 33 healthy individuals (control group) from Coimbra region for the presence of EBV by polymerase chain reaction (PCR) and by in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs). The status of H. pylori infection was assessed by serology and by PCR.ResultsEBV was detected by PCR in 90.2% of stomach cancer cases, whereas EBERs were detected in 11%. In our series, EBV-associated gastric carcinoma (EBVaGC) were significantly associated with gender and the majority of them presented lymph node metastasis. These cases were generally graded in more advanced pTNM stages and, non-surprisingly, showed worse survival. H. pylori infection was detected in 62.2% of the gastric cancers and 64.7% of these patients were CagA+. On the other hand, the H. pylori prevalence was higher in the EBV-negative gastric carcinomas (64.4%) than in those carcinoma cases with EBV+ (44.4%).ConclusionsThe present study shows that prevalence of EBVaGC among Portuguese population is in accordance with the worldwide prevalence. EBV infection seems to be associated to poorer prognostic and no relation to H. pylori infection has been found. Conversely, the presence of H. pylori seems to have a favourable impact on patient’s survival. Our results emphasize that geographic variation can contribute with new epidemiological data on the association of EBV with gastric cancer.

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Section: Discussionmentioning

confidence: 62%

Prevalence and characteristics of Epstein–Barr virus-associated gastric carcinomas in Portugal

Nogueira

Mota

Gradiz

et al. 2017

Infect Agents Cancer

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“…Gastroduodenoscopy examination is the most useful diagnostic tool for multiple gastric diseases. Chronic gastritis (including chronic nonatrophic and atrophic gastritis) and gastric cancer are commonly observed in the distal stomach 2, 3 . Thus, it is of clinical significance to differentiate chronic nonatrophic gastritis, chronic atrophic gastritis and gastric cancer if a lesion is suspected in the distal stomach.…”

Section: Introductionmentioning

confidence: 99%

Linked colour imaging benefits the endoscopic diagnosis of distal gastric diseases

Sun¹,

Bi²,

Dong³

et al. 2017

Sci Rep

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Gastric diseases are common in China, and gastroduodenoscopy could provide accurate diagnoses. Our previous study verified that linked colour imaging (LCI) can improve endoscopic diagnostic accuracy. This study aimed for the first time to establish an LCI-based endoscopic model called colour-microstructure-vessel (CMV) criteria and validated its clinical feasibility for detecting distal gastric diseases manifested as red mucosal lesions under endoscopy in a cohort of 62 patients. Colour features were extracted from the endoscopic images and categorized into 3 types. Colour type 1 was a typical red; Colour type 2 was red ringed with purple and Colour type 3 was red with yellow in the centre and purple around the periphery, allowing for predicting chronic nonatrophic gastritis, chronic atrophic gastritis and gastric cancer. The sensitivity, specificity and Youden index of Colour type 3 with abnormal M or V for gastric cancer were 100.0%, 98.2% and 98.2%. The kappa values for intra-observer and inter-observer agreement for predicting the pathology were 0.834 and 0.791 for experienced endoscopists and 0.788 and 0.732 for endoscopy learners, and these values were comparable regardless of the experience of the endoscopists (P > 0.05). These findings support that the CMV criteria are a promising model for accurate endoscopic diagnosis.

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“…The causal relationship between H. pylori infection and chronic active gastritis follows the Koch’s postulates . H. pylori infection can spread from person to person . Therefore, H. pylori gastritis is an infectious disease regardless of the presence of symptoms and/or complications.…”

Section: Etiology and Classification Of Chronic Gastritismentioning

confidence: 99%