Frequency of Takotsubo Cardiomyopathy in Postmenopausal Women Presenting With an Acute Coronary Syndrome

Sy, Fridolin; Basraon, Jagroop; Zheng, Hong; Singh, Manminder; Richina, Jonathan; Ambrose, John A.

doi:10.1016/j.amjcard.2013.04.010

Cited by 48 publications

(36 citation statements)

References 11 publications

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“…A diagnostic algorithm for these clinical scenarios has been summed up by the European task force on takotsubo in a recent position paper 2. In this decade of growing awareness among clinicians and patients alike, our own (unpublished) data as well as other centres’3 demonstrate that ~7% of all patients with presumed MI are in fact takotsubo.…”

Section: Incidence Acute Presentation Pathways and Mechanistic Pathomentioning

confidence: 97%

“…Many triggers have been described, for example, bereavement, near-miss road traffic accident, arguments, conflict, divorce, public speaking, a severe fright, protracted stress and hardship or any physical illness such as cancer, administration of chemotherapy, infections, diarrhoea/vomiting, routine general anaesthesia, cardioversions and many others. There is also a clear gender predilection towards women (in proportion of 9:1—prompting speculation about a neuroendocrine predisposition or a significant under-diagnosis in men), and although takotsubo was initially thought to affect mostly postmenopausal women,3 it has become clear that younger patients are equally vulnerable. Data from single centre cohorts and registries suggest that takotsubo presenters are less burdened by the usual risk factors associated with coronary heart disease but in exchange, a self-declared history of mental health or neurological disorders appears to decorate the medical history of these patients 8 24 45.…”

Section: Susceptibility and Predispositionmentioning

confidence: 99%

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Acute stress-induced (takotsubo) cardiomyopathy

Dawson

2017

Heart

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Acute stress-induced (takotsubo) cardiomyopathy has a dramatic clinical presentation, mimicking an acute myocardial infarction and is triggered by intense emotional or physical stress. In this paper, we review the current state of knowledge of the mechanistic physiology underlying the left ventricular ballooning. The pathophysiology of the recovery from this acute heart failure syndrome is presented. The short-term and long-term outlook puts this new syndrome on a different perspective compared with recently held views. Current knowledge on susceptibility and predisposition already define distinctive characteristics of patients with takotsubo compared with myocardial infarction. Gaps in knowledge and future directions of research are identified in order to best direct efforts for identifying specific therapies for this condition, in the acute setting, to mitigate postacute symptoms or to prevent recurrences, none of which exist.

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Section: Incidence Acute Presentation Pathways and Mechanistic Pathomentioning

confidence: 97%

Section: Susceptibility and Predispositionmentioning

confidence: 99%

Acute stress-induced (takotsubo) cardiomyopathy

Dawson

2017

Heart

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“…Odnotowana częstość tej kardiomiopatii wynosi 2% wśród pacjentów z ACS, jednak odsetek ten może być niedoszacowany [338,339]. U kobiet po menopauzie z podejrzeniem ACS zaobserwowana częstość występowania kardiomiopatii takotsubo wyniosła 5,9% [340]. U 3/4 pacjentów z kardiomiopatią takotsubo stężenie amin katecholowych jest wyższe.…”

Section: Przetoczenie Preparatów Krwiunclassified

2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Roffi¹,

Patrono²,

Collet³

et al. 2015

Kardiol Pol

208

165

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“…However, the most widely accepted mechanism refers to catecholamine-mediated cardiotoxicity. According to this theory, high levels of epinephrine promote the increased intracellular influx of calcium, resulting in myocardial and coronary hyperactivity, and consequently transient LV dysfunction 3 , 8. In this setting, TTC has been reported to occur during dobutamine infusion for diagnostic purposes 9.…”

Section: Introductionmentioning

confidence: 99%

Takotsubo cardiomyopathy: an overlooked cause of chest pain

Bermudes¹,

Tomazelli²,

Furieri³

et al. 2014

ACR

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Takotsubo cardiomyopathy (TTC), also known as apical ballooning syndrome, broken heart syndrome, or stress-induced cardiomyopathy, is defined as a transient disturbance of the left ventricle, which is quite often associated with electrocardiographic abnormalities that may mimic acute myocardial infarction. The syndrome is also characterized by a mild alteration of cardiac biomarkers in absence of coronary blood flow obstruction on the coronariography. Clinical presentation is often manifested by angina, dyspnea, syncope, and arrhythmias. Peculiarly, the left ventricle takes the form of “tako-tsubo” (a Japanese word for “octopus trap”) on the imaging workup. The authors report the case of a post-menopausal, hypertensive, dyslipidemic and type-II diabetic woman admitted at the emergency service with acute chest pain post physical exertion. Electrocardiogram showed signs of ischemia and myocardial necrosis markers were mildly increased. Echocardiography and ventriculography showed apical and mid-ventricular akinesia, with mild atherosclerotic coronary lesions. Thus diagnostic workup and the outcome followed the diagnostic criteria for TTC. The authors called attention to the potential of overlooking this diagnosis, since this syndrome is still not widely recognized.

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Frequency of Takotsubo Cardiomyopathy in Postmenopausal Women Presenting With an Acute Coronary Syndrome

Cited by 48 publications

References 11 publications

Acute stress-induced (takotsubo) cardiomyopathy

Acute stress-induced (takotsubo) cardiomyopathy

2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Takotsubo cardiomyopathy: an overlooked cause of chest pain

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