Frequency of Stroke and Embolism in Left Ventricular Hypertrabeculation/Noncompaction

Stöllberger, Claudia; Blazek, Gerhard; Dobias, Christoph; Hanafin, Aileen; Wegner, Christian; Finsterer, Josef

doi:10.1016/j.amjcard.2011.05.039

Cited by 130 publications

(102 citation statements)

References 13 publications

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“…464 Stroke rates may be higher in certain subgroups, including patients with prior stroke or TIA, lower ejection fraction, LV noncompaction, peripartum cardiomyopathy, and Chagas heart disease. [464][465][466][467][468][469] Conversely, ≈10% of patients with ischemic stroke have an LV ejection fraction ≤30%.…”

Section: Cardiomyopathymentioning

confidence: 99%

Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

Kernan¹,

Ovbiagele²,

Black³

et al. 2014

Stroke

3,942

1,326

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The aim of this updated guideline is to provide comprehensive and timely evidence-based recommendations on the prevention of future stroke among survivors of ischemic stroke or transient ischemic attack. The guideline is addressed to all clinicians who manage secondary prevention for these patients. Evidence-based recommendations are provided for control of risk factors, intervention for vascular obstruction, antithrombotic therapy for cardioembolism, and antiplatelet therapy for noncardioembolic stroke. Recommendations are also provided for the prevention of recurrent stroke in a variety of specific circumstances, including aortic arch atherosclerosis, arterial dissection, patent foramen ovale, hyperhomocysteinemia, hypercoagulable states, antiphospholipid antibody syndrome, sickle cell disease, cerebral venous sinus thrombosis, and pregnancy. Special sections address use of antithrombotic and anticoagulation therapy after an intracranial hemorrhage and implementation of guidelines.

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Section: Cardiomyopathymentioning

confidence: 99%

Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

Kernan¹,

Ovbiagele²,

Black³

et al. 2014

Stroke

3,942

1,326

View full text Add to dashboard Cite

show abstract

“…Its unusual presentation highlights the importance of a complete and thorough workup of patients presenting with apparently noncardiac symptom(s). Data is limited on specific therapy for VNC, but it is recommended that medical management be tailored towards the clinical manifestations, and standard guidelines should be applied for patients with reduced LVEF, and heart failure with preserved systolic function [12], in the setting of VNC. Patients with VNC, who meet standard criteria for anticoagulation, should also be managed according to standard guidelines [13].…”

Section: Resultsmentioning

confidence: 99%

Isolated Left Ventricular Noncompaction in a 25 Year Old Male

2016

IJSR

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Ventricular noncompaction (VNC) of the myocardium is a rare genetic cardiomyopathy caused by a disorder during endocardial morphogenesis and could be accompanied by life-threatening complications. The major clinical manifestations of VNC are heart failure, arrhythmias, and embolic events. The left ventricle is the most commonly reported affected site, but a few cases of right ventricular involvement have also been reported. We report the case of a young male who presented with features of heart failure. Trans thoracic echocardiography showed the characteristic trabeculations of left ventricular noncompaction with associated depressed left ventricular dysfunction.

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“…The Heart Failure Long-term Antithrombotic Study (HELAS) study failed to demonstrate a difference in the rate of embolization in patients with either ischemic or dilated cardiomyopathy treated with aspirin or warfarin. 30 The Warfarin/Aspirin Study in Heart failure (WASH) study similarly showed no difference in embolization rates in patients assigned to aspirin, warfarin, or no treatment. 32 The Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial compared aspirin, clopidigrel, and warfarin Statin therapy in patients with aortic arch disease was associated with a markedly reduced risk of IS in a retrospective study, with an odds ratio of 0.3 (95% CI 0.2-0.6) compared with placebo for IS, TIA, or peripheral emboli.…”

Section: Cardiomyopathymentioning

confidence: 99%