Frequency of Spontaneous BOLD Signal Differences between Moderate and Late Preterm Newborns and Term Newborns

Wu, Xiushuang; Wei, Luqing; Wang, Nan; Hu, Zhangxue; Wang, Li; Ma, Jun; Feng, Shuai; Cai, Yue; Song, Xiaopeng; Shi, Yuan

doi:10.1007/s12640-016-9642-4

Cited by 9 publications

(11 citation statements)

References 66 publications

(97 reference statements)

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“…Voxel-wise univariate research in newborn infants demonstrates reduced ALFF compared to term infants in a pattern consisting of the superior temporal gyri bilaterally and motor areas, in addition to increased ALFF of the precuneus and inferior temporal gyrus (Wu et al, 2016). The results of the current study in early adulthood support this research by demonstrating a persistence of reduced ALFF in bilateral superior temporal gyri.…”

Section: Patterns Of Aberrant Ongoing Brain Activity Fluctuationssupporting

confidence: 78%

“…The results of the current study in early adulthood support this research by demonstrating a persistence of reduced ALFF in bilateral superior temporal gyri. Interestingly, a previous study investigating ALFF in infants rather than adults did not find thalamic abnormalities (Wu et al, 2016), which may suggest early functional compensation that does not persist into adulthood or secondary disruption to development of functional networks (Fair et al, 2009). These findings agree with previous univariate region-of-interest network-based analyses using largely the same patient cohort demonstrating increased functional connectivity between this region and others.…”

Section: Patterns Of Aberrant Ongoing Brain Activity Fluctuationsmentioning

confidence: 87%

“…When combined with the previously described research demonstrating early thalamic lesions with later MRI volume changes, the results suggest that increased ALFF may be a downstream functional correlate in young adulthood of early thalamic damage. Interestingly, a previous study investigating ALFF in infants rather than adults did not find thalamic abnormalities (Wu et al, 2016), which may suggest early functional compensation that does not persist into adulthood or secondary disruption to development of functional networks (Fair et al, 2009).…”

Section: Patterns Of Aberrant Ongoing Brain Activity Fluctuationsmentioning

confidence: 87%

“…Low frequency fluctuations of the blood-oxygenation level-dependent fMRI signal putatively arise from the spontaneous neural activity of microcircuits and reflect the functional integrity of the brain (Sanchez-Vives, Massimini, & Mattia, 2017). These fluctuations are sensitive to changes in brain development (Smyser et al, 2013;Wu et al, 2016), aging (Biswal et al, 2010), cognitive deficits (Z. Deng, Chandrasekaran, Wang, & Wong, 2016;Takeuchi et al, 2015), psychiatric illness (Hare et al, 2016;Lui et al, 2015;Meda et al, 2015;Zhao et al, 2017), and neurodevelopmental disorders (Itahashi et al, 2015;F.…”

mentioning

confidence: 99%

“…Li et al, 2014; R. Li et al, 2015;Mascali et al, 2015). Previous research in newborns born prematurely has found reduced ALFF in the bilateral superior temporal gyri and increased ALFF of the precuneus and inferior temporal gyrus (Wu et al, 2016), but ALFF research in adults born preterm is limited (Shang et al, 2018).…”

mentioning

confidence: 99%

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A machine learning investigation of volumetric and functional MRI abnormalities in adults born preterm

Shang

Fisher

Bäuml

et al. 2019

Human Brain Mapping

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Imaging studies have characterized functional and structural brain abnormalities in adults after premature birth, but these investigations have mostly used univariate methods that do not account for hypothesized interdependencies between brain regions or quantify accuracy in identifying individuals. To overcome these limitations, we used multivariate machine learning to identify gray matter volume (GMV) and amplitude of low frequency fluctuations (ALFF) brain patterns that best classify young adults born very preterm/very low birth weight (VP/VLBW; n = 94) from those born full‐term (FT; n = 92). We then compared the spatial maps of the structural and functional brain signatures and validated them by assessing associations with clinical birth history and basic cognitive variables. Premature birth could be predicted with a balanced accuracy of 80.7% using GMV and 77.4% using ALFF. GMV predictions were mediated by a pattern of subcortical and middle temporal reductions and volumetric increases of the lateral prefrontal, medial prefrontal, and superior temporal gyrus regions. ALFF predictions were characterized by a pattern including increases in the thalamus, pre‐ and post‐central gyri, and parietal lobes, in addition to decreases in the superior temporal gyri bilaterally. Decision scores from each classification, assessing the degree to which an individual was classified as a VP/VLBW case, were predicted by the number of days in neonatal hospitalization and birth weight. ALFF decision scores also contributed to the prediction of general IQ, which highlighted their potential clinical significance. Combined, the results clarified previous research and suggested that primary subcortical and temporal damage may be accompanied by disrupted neurodevelopment of the cortex.

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Section: Patterns Of Aberrant Ongoing Brain Activity Fluctuationssupporting

confidence: 78%

Section: Patterns Of Aberrant Ongoing Brain Activity Fluctuationsmentioning

confidence: 87%

Section: Patterns Of Aberrant Ongoing Brain Activity Fluctuationsmentioning

confidence: 87%

mentioning

confidence: 99%

mentioning

confidence: 99%

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A machine learning investigation of volumetric and functional MRI abnormalities in adults born preterm

Shang

Fisher

Bäuml

et al. 2019

Human Brain Mapping

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Association Between Moderate and Late Preterm Birth and Neurodevelopment and Social-Emotional Development at Age 2 Years

et al. 2017

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IMPORTANCE Moderate and late preterm (MLPT) births comprise most preterm infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of developmental problems in MLPT children, detail is lacking on the precise domains that are affected. OBJECTIVE To compare neurodevelopment and social-emotional development between MLPT infants and term-born control infants at age 2 years. DESIGN, SETTING, AND PARTICIPANTS This investigation was a prospective longitudinal cohort study at a single tertiary hospital. Participants were MLPT infants (32-36 weeks' completed gestation) and healthy full-term controls (Ն37 weeks' gestation) recruited at birth. During a 3-year period between December 7, 2009, and November 7, 2012, MLPT infants were recruited at birth from the neonatal unit and postnatal wards of the Royal Women's Hospital, Melbourne, Australia. The term control recruitment extended to March 26, 2014. The dates of the data developmental assessments were February 23, 2012, to April 8, 2016. EXPOSURE Moderate and late preterm birth.MAIN OUTCOMES AND MEASURES Cerebral palsy, blindness, and deafness assessed by a pediatrician; cognitive, language, and motor development assessed using the Bayley Scales of Infant Development-Third Edition (developmental delay was defined as less than −1 SD relative to the mean in controls in any domain of the scales); and social-emotional and behavioral problems assessed by a parent questionnaire (Infant Toddler Social Emotional Assessment). Outcomes were compared between birth groups using linear and logistic regression, adjusted for social risk. RESULTSIn total, 198 MLPT infants (98.5% of 201 recruited) and 183 term-born controls (91.0% of 201 recruited) were assessed at 2 years' corrected age. Compared with controls, MLPT children had worse cognitive, language, and motor development at age 2 years, with adjusted composite score mean differences of −5.3 (95% CI, −8.2 to −2.4) for cognitive development, −11.4 (95% CI, −15.3 to −7.5) for language development, and −7.3 (95% CI, −10.6 to −3.9) for motor development. The odds of developmental delay were higher in the MLPT group compared with controls, with adjusted odds ratios of 1.8 (95% CI, 1.1-3.0) for cognitive delay, 3.1 (95% CI, 1.8-5.2) for language delay, and 2.4 (95% CI, 1.3-4.5) for motor delay. Overall social-emotional competence was worse in MLPT children compared with controls (t statistic mean difference, −3.6 (95% CI, −5.8 to −1.4), but other behavioral domains were similar. The odds of being at risk for social-emotional competence were 3.9 (95% CI, 1.4-10.9) for MLPT children compared with controls.CONCLUSIONS AND RELEVANCE Moderate and late preterm children exhibited developmental delay compared with their term-born peers, most marked in the language domain. This knowledge of developmental needs in MLPT infants will assist in targeting surveillance and intervention.

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Frequency-specific altered global signal topography in drug-naïve first-episode patients with adolescent-onset schizophrenia

Wang

Liao

Han

et al. 2020

Brain Imaging and Behavior

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Frequency of Spontaneous BOLD Signal Differences between Moderate and Late Preterm Newborns and Term Newborns

Cited by 9 publications

References 66 publications

A machine learning investigation of volumetric and functional MRI abnormalities in adults born preterm

A machine learning investigation of volumetric and functional MRI abnormalities in adults born preterm

Association Between Moderate and Late Preterm Birth and Neurodevelopment and Social-Emotional Development at Age 2 Years

Frequency-specific altered global signal topography in drug-naïve first-episode patients with adolescent-onset schizophrenia

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