Frequency of Serological Tests Positive Findings for Celiac Disease at the First Relative of Children with Celiac Disease

Abstract

oal: The research was undertaken with the aim to determine the frequency of positive findings of serological tests for celiac disease of the first relatives of children with celiac disease. Materials and methods: The study included 175 first relatives of 68 children suffering from celiac disease. Of that number, 75 (40 mothers and 26 fathers), 4 sisters and five brothers agreed to be tested for the presence of antibodies to celiac disease. For each subject were done tests on presence of anti-gliadin IgA, IgG antigliadin antibodies and IgA antibodies on tissue transglutaminase in the Poly

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

“…Twenty‐nine studies on first‐degree relatives fulfilled our inclusion criteria . Of these, 1.97–20.73% were positive for EMA, 4.00–23.81% had elevated levels of tTG, while 0.87–23.81% had Marsh 3 changes or villous atrophy on histology.…”

Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta-Analysis

“…Forty-eight studies were included in this part of analysis as they reported serological prevalence among FDRs with one index case of CD ( 9,(11)(12)(13)(14)(30)(31)(32)(33)(34)(35)(36)39,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(52)(53)(54)(55)(56)(57)(58)(59)(60)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78). Overall, of 14,225 FDRs screened using AEA and/or anti-tTG Ab, 1,016 FDRs were seropositive ( 9,(11)…”