Frequency of periodontal pathogens and Helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study

Abstract

Objectives This cross-sectional study compared the frequency of oral periodontopathogens and H. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery.Material and Methods One hundred and fifty-four men and women aged 18-65 were conveniently distributed into four groups. Two groups were composed of individuals who underwent bariatric surgery with (BP) (n=40) and without (BNP) (n=39) periodontitis and two obese control groups with (CP) (n=35) and without (CNP) (n=40) periodontitis. The oral pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Parvimonas micra, Treponema denticola, Tannerella forsythia, Campylobacter rectus, and Helicobacter pylori were detected by a polymerase chain reaction technique using saliva, tongue and stomach biopsy samples.Results Statistical analysis demonstrated that periodontopathogens were highly frequent in the mouth (up to 91.4%). In the bariatric surgically treated group, orally, P. gingivalis, T. denticola and T. forsythia were more frequent in periodontitis, while C. rectus was more frequent in non-periodontitis subjects. Stomach biopsies also revealed the high frequency of five oral species in both candidates for bariatric surgery (91.6%) and the bariatric (83.3%) groups. H. pylori was frequently detected in the mouth (50.0%) and stomach (83.3%). In the stomach, oral species and H. pylori appeared in lower frequency in the bariatric group.Conclusions Obese individuals showed high frequencies of periodontopathogens and H. pylori in their mouths and stomachs. Bariatric surgery showed an inverse microbial effect on oral and stomach environments by revealing higher oral and lower stomach bacterial frequencies.

Kavain Reduces Porphyromonas gingivalis–Induced Adipocyte Inflammation: Role of PGC-1α Signaling

“…For instance, specific profiles of gut microbiota are associated with increased obesity-related clinical parameters due to activation of specific molecular pathways resulting in a dysregulated inflammatory response (33). Due to a reported relationship between periodontitis and obesity, several studies focused on P.gingivalis due to its frequent occurrence in obese patients (34). P.gingivalis , as well as other pathogens from periodontal biofilms, is able to bypass the epithelial barrier of the periodontal pocket, to spread within connective tissues, to disseminate through blood flow and to overcome the innate immune response allowing its persistance within cells contributing to low-chronic inflammation at a distance from the source of infection (35).…”

Periodontal complications with obesity

“…An investigation of obese individuals after bariatric surgery and an obese control group with or without periodontitis compared the oral and gastric presence of periodontal pathogens and Helicobacter pylori. Higher frequency of H. pylori was reported in both oral and stomach environments in patients who had undergone bariatric surgery compared with the obese control group (no surgery) 147.…”

“…Quality assessment of included publications according to A MeaSurement Tool to Assess systematic Reviews (AMSTAR) II, and III. The reported odds ratios were 1.20, 1.46, 1.78, and 2.31, respectively, for each body mass index group, inferring a dose-response association 147. A statistically significant association between the number of teeth with deepened pockets and body mass index, body fat percentage, and waist circumference was demonstrated in a Finnish population sample 148.…”

Avaliação das alterações bucais em pacientes submetidos à gastroplastia

“…Com isso, houve um aumento da porcentagem de indivíduos obesos associado à algumas comorbidades sistêmicas, como: hipertensão arterial, osteoartrite, diabetes, câncer, apneia do sono, além de alterações na cavidade bucal, principalmente relacionado às doenças periodontais (Moura-Grec et al, 2012;Freitas, 2015;Pataro et al, 2016;Bastos, 2018).…”