Frequency of Osteosarcoma Among First-Degree Relatives of St. Bernard Dogs2

Bech-Nielsen, S; Haskins, Mark E.; Reif, John S.; Brodey, Robert S.; Patterson, Donald F.; Spielman, Richard S.

doi:10.1093/jnci/60.2.349

Cited by 23 publications

(8 citation statements)

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“…While the aetiology of osteosarcoma is still uncertain in dogs and humans, several contributing factors have been suggested. Factors such as ionizing radiation, genetics, bone tumour viruses, chemicals, chronic irritation due to fractures repaired by metallic implants, bone infarcts, skeletal diseases or disorders as well as body size and sex are believed to be involved in pathogenesis …”

Section: Aetiologymentioning

confidence: 99%

“…While the aetiology of osteosarcoma is generally unknown in both dogs and humans, a proposed association with ionizing radiation has been reported with oral and maxillofacial osteosarcomas . Other reported possible aetiologies include genetics, pre‐existing bone disease, trauma, bone viruses and metallic bone implants …”

Section: Introductionmentioning

confidence: 99%

“…13 -18 While the aetiology of osteosarcoma is generally unknown in both dogs and humans, a proposed association with ionizing radiation has been reported with oral and maxillofacial osteosarcomas. 19 -21 Other reported possible aetiologies include genetics, 22,23 pre-existing bone disease, 2,24 trauma, 1,23 bone viruses 1,23 and metallic bone implants. 25 -28 In general, osteosarcoma, of which the appendicular form predominates, has a strong predilection for specific anatomical sites such as distal radius, proximal humerus, distal femur and proximal tibia.…”

Section: Introductionmentioning

confidence: 99%

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Oral and maxillofacial osteosarcoma in dogs: a review

Farcas

Arzi

Verstraete

2012

Vet Comparative Oncology

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Osteosarcoma in dogs is a heterogeneous disease entity with regard to its histologic, clinical and biologic behaviour. Differences in behaviour are associated with tumour location. Oral and maxillofacial osteosarcomas are typically reported as a component of the broader classifications of axial osteosarcoma or osteosarcoma of flat bones to differentiate them from appendicular osteosarcoma. Similar to human oral and maxillofacial osteosarcoma, in dogs, these also appear to have less aggressive behaviour than appendicular osteosarcoma. Ideally, local control is achieved with wide surgical resection that results in tumour-free margins. Failure of local control is the most common contributor to poor prognosis. Chemotherapy and radiation treatment are reported to have variable outcomes. The aim of this article is to review the literature on oral and maxillofacial osteosarcoma in dogs in comparison to appendicular and axial osteosarcoma. Similarities and differences between oral and maxillofacial osteosarcoma in humans are addressed.

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Section: Aetiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oral and maxillofacial osteosarcoma in dogs: a review

Farcas

Arzi

Verstraete

2012

Vet Comparative Oncology

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“…These range from relatively simple traits, such as variation in coat color (1) and numerous single gene disorders (2)(3)(4), through a range of well described clinical disorders and other phenotypes exhibiting complex inheritance (3)(4)(5)(6)(7)(8)(9)(10). In addition, there is the diverse repertoire of morphological and͞or behavioral characteristics that define and distinguish the numerous specific breeds of dog.…”

mentioning

confidence: 99%

Linkage analysis and comparative mapping of canine progressive rod–cone degeneration ( prcd ) establishes potential locus homology with retinitis pigmentosa (RP17) in humans

Acland

Ray

Mellersh

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

102

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Progressive rod-cone degeneration (prcd) is the most widespread hereditary retinal disease leading to blindness in dogs and phenotypically is the canine counterpart of retinitis pigmentosa (RP) in humans. In previous efforts to identify the genetic locus for prcd, the canine homologs for many of the genes causally associated with RP in humans, such as RHO, PDE6B, and RDS͞peripherin, have been excluded. In parallel with a recent undertaking to establish a framework map of the canine genome, multiple prcdinformative pedigrees have been typed with a panel of more than 100 anchor loci and microsatellite-based markers. Identification of a linkage group f lanking prcd ([TK1, GALK1, prcd]-[MYL4, C09.173, C09.2263]-RARA-C09.250-C09.474-NF1) localizes prcd close to the centromeric end of canine chromosome 9 (CFA9), and excludes RARA as a candidate gene. The conserved synteny of this region of CFA9 and distal human chromosome 17q establishes the potential locus homology of prcd in the dog with RP17, a human retinitis pigmentosa locus for which no gene has yet been identified. Assignment of the prcd disease locus to an identified canine autosome represents a powerful application of the developing canine linkage map in medical genetics. The usefulness of this approach is further demonstrated by identification of the correspondence of the prcd interval to homologous human and mouse chromosomal regions. The rapid progress that is now occurring in the field of canine genetics will expedite the identification of the genes underlying many of the inherited traits and diseases that make the dog a unique asset for the study of mammalian traits.

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“…Large and giant breeds such as Great Danes, St. Bernards, Irish Setters, Golden Retrievers, Rottweilers, and Doberman Pinschers, develop the disease frequently (Tjalma 1996). A genetic component to canine osteosarcoma has previously been described in St. Bernards, but no gene has been cloned or even mapped (Bech-Nielsen et al 1978). …”

Section: Model Diseases: Cancer In Dogsmentioning

confidence: 99%