Frequency of Oral Manifestations of Chronic Graft-Versus-Host Disease in Hematopoietic Stem Cell Transplant Recipients

Noce, Cesar Werneck; Gomes, A. M.; Moreira, Maria Cláudia Rodrigues; Shcaira, Vanessa; Corrêa, Maria Elvira P.; Maiolino, Ângelo; Torres, Sandra Regina

doi:10.1016/j.oooo.2013.12.306

Cited by 13 publications

(29 citation statements)

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“…[91] The pathogenesis of GVHD is based on donor graft T-lymphocytes that recognize antigenic disparities between donor and recipient and the dysregulation of a broad panel of cytokines. GVHD occurs in 40-70% of patients treated by bone marrow and peripheral blood stem cell transplantation.…”

Section: Resultsmentioning

confidence: 99%

Xerostomia due to systemic disease: A review of 20 conditions and mechanisms

Mortazavi

Baharvand

Movahhedian

et al. 2014

Ann Med Health Sci Res

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Xerostomia is a common complaint of nearly half of the elderly population and about one-fifth of younger adults. It causes several signs and symptoms, and compromise oral functions and health-related quality-of-life. Multiple reasons are proposed to describe the etiology of xerostomia such as local factors, psychogenic factors, and systemic diseases. In order to manage xerostomia effectively, identification of the main causality is mandatory. The aim of this review was to present systemic diseases leading to xerostomia with their mechanisms of action. We used various general search engines and specialized databases such as Google, Google Scholar, Yahoo, PubMed, PubMed Central, MedLine Plus, Medknow, EBSCO, ScienceDirect, Scopus, WebMD, EMBASE, and authorized textbooks to find relevant topics by means of Medical Subject Headings keywords such as “xerostomia,” “hyposalivations,” “mouth dryness,” “disease,” and “systemic.” We appraised 97 English-language articles published over the last 40 years in both medical and dental journals including reviews, meta-analysis, original papers, and case reports. Upon compilation of relevant data, it was concluded that autoimmune diseases most frequently involve salivary glands and cause xerostomia followed by diabetes mellitus, renal failure, and graft-versus-host disease. Moreover, the underlying mechanisms of systemic disease-related xerostomia are: autoimmunity, infiltration of immunocompetent cells, granuloma formation, fibrosis and dehydration, deposition of proteinaceous substances, bacterial infection, and side-effects of medications.

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Section: Resultsmentioning

confidence: 99%

Xerostomia due to systemic disease: A review of 20 conditions and mechanisms

Mortazavi

Baharvand

Movahhedian

et al. 2014

Ann Med Health Sci Res

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“…The oral cavity is one of the most frequently affected sites and may be the initial location of cGVHD activity (Woo et al, 1997;Noce et al, 2011;Castellarin et al, 2012;Hull et al, 2012). The primary clinical feature is mucosal lichenoid inflammation characterized by pain and sensitivity leading to limited oral intake and a diminished quality of life (Filipovich et al, 2005;Martin et al, 2006;Treister et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Oral chronic GVHD outcomes and resource utilization: a subanalysis from the chronic GVHD consortium

et al. 2016

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“…In cGVHD, damage to salivary glands is rapid and often severe, affecting both overall saliva production and composition [27–29]. Patients typically have higher concentrations of metal ions such as sodium and magnesium, as well as albumin, IgG and total protein [30,31].…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of Saliva from Patients with Oral Chronic Graft-Versus-Host Disease

Devic

Shi

Schubert

et al. 2014

Biology of Blood and Marrow Transplantation

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Chronic graft-versus-host disease (cGVHD) is an immune-mediated disorder and is the major long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The oral mucosa including the salivary glands is affected in the majority of cGVHD patients; however, at present there is only a limited understanding of disease pathobiology. In this study, we performed a quantitative proteomic analysis of saliva pooled from oral cGVHD(+) and oral cGVHD(-) patients using iTRAQ (isobaric Tags for Relative and Absolute Quantification) labeling, followed by tandem mass spectrometry. Among 249 salivary proteins identified by tandem mass spectrometry, 82 proteins exhibited altered expression in oral cGVHD patients compared to allo-HSCT patients without oral cGVHD. Many of the identified proteins function in innate or acquired immunity, or are associated with tissue maintenance functions such as proteolysis or the cytoskeleton. Using ELISA immunoassays, we further confirmed that two of these proteins, IL-1 receptor antagonist and Cystatin B, showed decreased expression in patients with active oral cGVHD (P < 0.003). Receiver Operator Characteristic analysis revealed that these two markers were able to distinguish oral cGVHD with a sensitivity of 85% and specificity of 60%, and showed slightly better discrimination in newly diagnosed patients studied within 12 months of allo-HSCT transplantation (sensitivity, 92%; specificity 73%). In addition to identifying novel potential salivary cGVHD biomarkers, our study demonstrates that there is coordinated regulation of protein families involved in inflammation, anti-microbial defense and tissue protection in oral cGVHD that may also reflect changes in salivary gland function and damage to the oral mucosa.

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Frequency of Oral Manifestations of Chronic Graft-Versus-Host Disease in Hematopoietic Stem Cell Transplant Recipients

Cited by 13 publications

References 0 publications

Xerostomia due to systemic disease: A review of 20 conditions and mechanisms

Xerostomia due to systemic disease: A review of 20 conditions and mechanisms

Oral chronic GVHD outcomes and resource utilization: a subanalysis from the chronic GVHD consortium

Proteomic Analysis of Saliva from Patients with Oral Chronic Graft-Versus-Host Disease

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