Frequency of non-right-handedness in bipolar disorder and schizophrenia

Ravichandran, Caitlin; Shinn, Ann K.; Öngür, Döst; Perlis, Roy H.; Cohen, Bruce M.

doi:10.1016/j.psychres.2017.04.011

Cited by 22 publications

(17 citation statements)

References 14 publications

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“…Nevertheless, we observed a clear inflation of the distribution of P values when compared to the null, which indicates that there is likely to be a small degree of genetic overlap between handedness and other traits. Among the suggestive genetic correlations (P < 0.05), we observed positive genetic correlations between left-handedness and schizophrenia and bipolar disorder, which is consistent with previous observations of greater atypical hand dominance in patients with schizophrenia and in patients with bipolar disorder 53,54 .…”

Section: Discussionsupporting

confidence: 91%

Genome-wide association study identifies 48 common genetic variants associated with handedness

et al. 2020

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Genome-wide association study identifies 48 common genetic variants associated with handedness Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10 −8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r G = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

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Section: Discussionsupporting

confidence: 91%

Genome-wide association study identifies 48 common genetic variants associated with handedness

et al. 2020

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“…In the patients, we found no clear pattern of left-hemisphere specificity for the language variables. There is strong evidence for reduced (functional) lateralization in schizophrenia, which is evidenced by increased mixed-handedness 57 and diminished language lateralization [58][59][60][61] . Schizophrenia patients show a reduction of left-lateralization in several white matter language tracts, including the UF [62][63][64] and the IFOF 64 .…”

Section: Discussionmentioning

confidence: 99%

Language in schizophrenia: relation with diagnosis, symptomatology and white matter tracts

et al. 2020

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Language deviations are a core symptom of schizophrenia. With the advances in computational linguistics, language can be easily assessed in exact and reproducible measures. This study investigated how language characteristics relate to schizophrenia diagnosis, symptom, severity and integrity of the white matter language tracts in patients with schizophrenia and healthy controls. Spontaneous speech was recorded and diffusion tensor imaging was performed in 26 schizophrenia patients and 22 controls. We were able to classify both groups with a sensitivity of 89% and a specificity of 82%, based on mean length of utterance and clauses per utterance. Language disturbances were associated with negative symptom severity. Computational language measures predicted language tract integrity in patients (adjusted R 2 = 0.467) and controls (adjusted R 2 = 0.483). Quantitative language analyses have both clinical and biological validity, offer a simple, helpful marker of both severity and underlying pathology, and provide a promising tool for schizophrenia research and clinical practice.

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“…In Western countries ~ 85-90 percent of the population are right-handed and ~10-15 percent are left-handed (Harris 1990). The elevated prevalence of non-right-handedness in psychiatric disorders as compared with healthy population is a true empirical effect (Deep-Soboslay et al 2010;Hirnstein and Hugdahl 2014;Ravichandran et al 2017). A few meta-analyses have reported that the odds of being non-right-handed are approximately 1.5 times higher in people with schizophrenia than in controls (Sommer et al, 2001;Hirnstein and Hugdahl, 2014).…”

Section: Introductionmentioning

confidence: 99%

40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender

et al. 2017

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The 40 Hz auditory steady-state response (ASSR) is a periodic response to a periodic stimulation. Its sources are located in the primary auditory cortex and the asymmetry of the planum temporale has previously been associated with hand preference and gender-related differences; thus subject's handedness and gender could potentially influence ASSRs. Nevertheless, electrophysiological studies of ASSRs are mainly dominated by right-handed participants and the observed findings can only be generalized to the right-handed populations. However, for a potential use of 40 Hz ASSR as a translational biomarker of neuropsychiatric disorders, it is important to investigate the response in association to handedness and gender. We included an equal number of left-handed and right-handed males and females and recorded EEG responses during left-ear, right-ear and both ears stimulation. The results of the study suggest that the processing of 40 Hz auditory stimulation depends on the subjects' gender and handedness: significantly lower phase-locking and strength of 40 Hz ASSRs were observed in left-handed females as compared to left-handed males, but right-handers did not differ in 40 Hz ASSRs. Our observation of the opposite impact of gender in the examined handedness groups stresses the importance of careful consideration of handedness and gender factors when evaluating the determinants of inter individual variability of 40 Hz ASSRs. This finding is of particular importance for clinical studies in psychiatry and neurology.

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Frequency of non-right-handedness in bipolar disorder and schizophrenia

Cited by 22 publications

References 14 publications

Genome-wide association study identifies 48 common genetic variants associated with handedness

Genome-wide association study identifies 48 common genetic variants associated with handedness

Language in schizophrenia: relation with diagnosis, symptomatology and white matter tracts

40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender

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