Frequency of mucosal HPV DNA detection (types 6/11, 16/18, 31/35/51) in skin lesions of renal transplant patients

Mansat-Krzyzanowska, E.; Dantal, J.; Hourmant, Maryvonne; Litoux, P; Soulillou, Jean‐Paul; Drégno, B.

doi:10.1111/j.1432-2277.1997.tb00556.x

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…reported that, of the 18 cutaneous warts in transplant recipients, HPV 6/11 was detected in four of the samples (4/18, 36%). In another study, in 11 out of 34 (32.4%) benign lesions in renal transplant patients, cutaneous warts were positive for HPV DNA: eight common warts (three type 6/11, two type 16/18, one type 16/18 and 31/35/51, and two type 31/35/51) and three plantar warts (two type 16/18 and one type 31/35/51) . In the control group, three out of 30 (10%) benign lesions were positive: two common warts (one type 16/18 and one type 31/35/51) and one plantar wart (type 16/18).…”

Section: Discussionmentioning

confidence: 94%

“…Cutaneous HPV type 1 is frequently detected in plantar warts, and HPV 2, 4, 7 and 57 are reportedly found in common warts . Recently, there have been several reports on detection of mucosal HPV in skin lesions of transplant patients . Various hybridization techniques such as filter in situ hybridization, Southern blot hybridization, and polymerase chain reaction (PCR) were developed to detect HPV genotypes.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary study of analyzing mucosal human papillomaviruses in cutaneous warts by restriction fragment mass polymorphism

Park

Kim

et al. 2017

The Journal of Dermatology

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Cutaneous human papillomavirus (HPV) types 1, 2, 4, 7 and 57 are reportedly found in cutaneous warts. However, there are few reports that have investigated the prevalence of mucosal HPV types in cutaneous warts. The aim of this study is to investigate the prevalence of mucosal HPV types in patients with cutaneous warts and to determine any association between HPV types and patient characteristics. We analyzed 62 wart samples that were taken from patients who were diagnosed with cutaneous warts, and 30 normal skin samples were used as negative control. We recorded the following characteristics: sex, age, type of warts, duration of warts, number of warts and patient's immune status. A matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS)-based restriction fragment mass polymorphism (RFMP) assay was used for HPV genotyping. Of the total 62 wart samples, 50 samples (81.6%) were positive for HPV genotypes. All of the negative controls (30 samples) using normal skin showed negative reaction. Mucosal HPV types (49 samples, 84.4%) were highly detected, and high- or probable high-risk HPV types (39 samples, 67.2%) were more common than lower risk HPV types (10 samples, 17.2%). A statistically significant association was observed between sex, age, duration of warts and the risk of HPV types. To the best of our knowledge, this is the first study to use the RFMP assay to analyze cutaneous wart-associated mucosal HPV types. The high prevalence of high-risk and probable high-risk HPV in this study is of great significance.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Preliminary study of analyzing mucosal human papillomaviruses in cutaneous warts by restriction fragment mass polymorphism

Park

Kim

et al. 2017

The Journal of Dermatology

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“…They can occur on multiple localities and are mostly detected on sun‐exposed areas of skin. The identified mucosal viral types in warts of OTRs are HPV 1, 2, 3, 4 and 10, which are also detected in immunocompetent patients, and in addition low‐risk types HPV 6 and 11 and high‐risk types HPV 16, 18, 31, 35 and 51 6–9 …”

Section: Introductionmentioning

confidence: 99%

Viral warts in organ transplant recipients: new aspects in therapy

et al. 2003

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The long-term success of organ transplantation depends on the prevention of allograft rejection and improvement in quality of life for the patients. This has been achieved through better immunosuppressive regimens with lower dosages and a new generation of immunosuppressive drugs. However, these immunosuppressive agents not only impair the patient's reactivity to the graft, but also to infectious organisms, thereby making them more susceptible to opportunistic pathogens. Because of this, organ transplant recipients are predisposed to epithelial malignancies and infections. The majority of transplant recipients will develop warts induced by human papillomavirus (HPV). Some of these viral warts may present with atypical histological features and may progress into squamous cell carcinomas. The risk for cutaneous cancers after transplantation is much higher than in the immunocompetent population. Current therapies for HPV-associated skin tumours mainly depend on the destruction of affected skin areas. These treatment modalities are of limited efficacy and are usually painful for the patients. A promising novel therapeutic agent is imiquimod, an immune response modifier. Clinical efficacy of imiquimod has been observed for different skin lesions, including viral warts in both immunocompetent and immunosuppressed patients.

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Multiple Types of High-Risk Human Papilloma Virus in the Lower Genital Tract of a Female Kidney Recipient: A Case Report

Pietrzak¹,

Bobrowska²,

Szpotanska‐Sikorska³

et al. 2011

Transplantation Proceedings

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Frequency of mucosal HPV DNA detection (types 6/11, 16/18, 31/35/51) in skin lesions of renal transplant patients

Cited by 7 publications

References 33 publications

Preliminary study of analyzing mucosal human papillomaviruses in cutaneous warts by restriction fragment mass polymorphism

Preliminary study of analyzing mucosal human papillomaviruses in cutaneous warts by restriction fragment mass polymorphism

Viral warts in organ transplant recipients: new aspects in therapy

Multiple Types of High-Risk Human Papilloma Virus in the Lower Genital Tract of a Female Kidney Recipient: A Case Report

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