Frequency of Intracranial Aneurysms Determined by Magnetic Resonance Angiography in Children (Mean Age 16) Having Operative or Endovascular Treatment of Coarctation of the Aorta (Mean Age 3)

Mind the Brain: Stroke Risk in Young Adults With Coarctation of the Aorta

“…The former hypothesis could mean that these aneurysms are different in nature and, thus, may have implications in terms of rupture risk and treatment, whereas the latter hypothesis would suggest that they occur because of the earlier development of risk factors, such as hypertension. One recent study found no intracranial aneurysms in a group of patients who all underwent CoA repair early in life and had magnetic resonance angiographic screening for intracranial aneurysms in adolescence . Although such findings call the developmental hypothesis into question, it remains a possibility given that in the present study there were no significant differences between the groups in terms of other modifiable risk factors.…”

“…One recent study found no intracranial aneurysms in a group of patients who all underwent CoA repair early in life and had magnetic resonance angiographic screening for intracranial aneurysms in adolescence. 12 Although such findings call the developmental hypothesis into question, it remains a possibility given that in the present study there were no significant differences between the groups in terms of other modifiable risk factors.…”

Long-Term Risk of Hemorrhagic Stroke in Young Patients With Congenital Heart Disease

“… 13 However, the occurrence of intracranial aneurysms in patients with CoA has recently been questioned, as no cases of intracranial aneurysm were found in 80 children treated for coarctation. 17 Our data would seem to contradict this and lend support to previous observations of a high prevalence of intracranial aneurysms, and the potential for such aneurysms to rupture and cause SAH, in patients with CoA. 18 …”

Prevalence of Intracranial Aneurysm in Patients with Aortopathy: A Systematic Review with Meta-Analyses

“…Of 100 studies considered for eligibility, 13 records were included in the full-text assessment. In the process of screening, one study was conducted in children (mean age 16) with CoA, 17 and we excluded this article for the specific study population, and we also excluded a cohort study in which not all participants were patients with brain imaging. 18 After an inter-observer agreement between reviewers for study inclusion, three studies considering the prevalence of aortic disease in patients with IA were included in qualitative analysis, and a total of ten studies were included in the meta-analysis which reported an estimated prevalence of IA among patients with aortopathy.…”