Long-Term Risk of Hemorrhagic Stroke in Young Patients With Congenital Heart Disease

Abstract

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Impact of Atrial Fibrillation on Survival in Adults with Congenital Heart Disease: a Retrospective Population-based Study

“…The odds ratio for coronary artery disease in ACHD was associated with atherosclerotic risk factors in Canada, 29 30 and the relative risk for hemorrhagic stroke with CHD was 8 folds higher than that of matched controls from the general population in Sweden. 31 There was a significantly higher death risk for ACHD depending on a relatively lower income level. Income inequality can actually affect cardiovascular disease.…”

A novel TBX5 mutation predisposes to familial cardiac septal defects and atrial fibrillation as well as bicuspid aortic valve

“…As the most prevalent type of human birth defect, congenital heart defect (CHD) occurs in about 1% of all live neonates, accounting for nearly a third of all forms of developmental abnormalities (Benjamin et al, 2019;Oliveira-Brancati et al, 2020). Although minor CHD may resolve spontaneously (Benjamin et al, 2019), serious CHD may lead to poor health-related quality of life (Amedro et al, 2018(Amedro et al, , 2019Boukovala et al, 2019), reduced exercise capacity (Müller et al, 2018;Abassi et al, 2019;Smith et al, 2019), abnormal nervous develop ment or brain injury (Peyvandi et al, 2018(Peyvandi et al, , 2019Khanna et al, 2019), hemorrhagic or ischemic stroke (Bokma et al, 2018;Giang et al, 2018;Pedersen et al, 2019), pulmonary hypertension (Brida and Gatzoulis, 2018;Dimopoulos et al, 2018;Kaemmerer et al, 2018;Pascall and Tulloh, 2018), acute kidney injury or renal dysfunction (Lui et al, 2017;Gist et al, 2018), infective endocarditis (Jortveit et al, 2018;Tutarel et al, 2018;Cahill et al, 2019), cardiac dysfunction or congestive heart failure (Gilbert et al, 2018;Lal et al, 2018;Sabanayagam et al, 2018;Chan et al, 2019), ventricular or supraventricular dysrhythmia (Labombarda et al, 2017;Barry et al, 2018;Hernández-Madrid et al, 2018;Fuchs et al, 2019), and death (Lynge et al, 2018;Yu C et al, 2018). Although vast advance in cardiac surgery allows over 90% of CHD newborns to survive into adulthood, it results i...…”

Adults With Complex Congenital Heart Disease: Cerebrovascular Considerations for the Neurologist

“…A registry study of 22,000 ACHD patients matched ten to one with random controls from the general population found an increased rate of intracerebral hemorrhage (ICH) as well as subarachnoid hemorrhage (SAH) in the ACHD group over 27 years of follow-up (36). For ACHD, incidence rate ratios (IRR) for intracerebral (ICH) and subarachnoid hemorrhage (SAH) were 8·23 (95%CI 6·0–11·2) and 7·64 (95%CI 5·41–10·7), respectively.…”