Frequency of Insulin Resistance in Egyptian Women with Polycystic Ovary Syndrome

Abstract

Objectives: To evaluate the prevalence of insulin resistance in polycystic ovary syndrome (PCOS) women and to compare the findings (clinical and laboratory) of PCOS in insulin resistance (IR) to non-IR PCOS women. Patients and methods:Fifty PCOS women included in this cross sectional comparative study. Studied women underwent complete physical examination with calculation of BMI, assessment of hirsutism and measurement of blood pressure. Hormonal and lipid profiles of the studied PCOS women also evaluated. Fasting glucose/insulin (G/I) ratio calculated and a ratio < 4.5 was predictive of IR in PCOS women above 18 years old. Studied PCOS women divided into two groups according to presence or absence of IR to evaluate the prevalence of IR in PCOS Egyptian women and to compare the findings (clinical and laboratory) of PCOS in IR to non-IR PCOS women.Results: IR (G/I ratio <4.5) detected in 46% (23/50) of studied PCOS women. BMI was significantly high in IR compared to non-IR PCOS women (32.6 ± 6.0 Kg/m 2 versus 29.5 ± 4.0) and the hirsutism (Ferriman Gallway score >8) was significantly more common in IR compared to non-IR PCOS women (20 (86.95%) versus 5 (18.5%)). There was no significant difference between IR and non-IR PCOS studied women regarding; mean age, blood pressure, age of menarche, menstrual regularity, acne and baldness. In addition, there was no significant difference between the IR women and non-IR PCOS studied women regarding; ultrasound ovarian findings, hormonal and lipid profiles. Conclusion:The prevalence of IR in PCOS Egyptian women is about 46%, BMI was significantly high in IR compared to non-IR PCOS women and the hirsutism was significantly more common in IR compared to non-IR PCOS women.

Combination of pioglitazone and clomiphene citrate versus clomiphene citrate alone for infertile women with the polycystic ovarian syndrome

“…6 School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 7 GREENWICH University England, London, England.…”

“…Hyperinsulinemia and insulin resistance (IR) are common in PCOS. Mostafa et al found that about 46% of Egyptian PCOS women had IR [4,7]. Insulin disrupts steroidogenesis in the ovary independently from gonadotropin secretion I PCOS [1].…”

“…Abnormal glucose metabolism may significantly improve weight loss; weight loss may reduce hyperandrogenism and reinstate ovulation function [7]. Obese women with insulin resistance, caloric restriction, and weight loss reduce the severity of insulin resistance.…”

“…Insulin resistance means decreased glucose response to insulin with subsequent hyperinsulinemia, which leads to elevated triglyceride, and decreased HDL-cholesterol, glucose intolerance, and cardiovascular risks [10]. Pioglitazone, used as a treatment for type 2 diabetes, directly affects peripheral insulin sensitivity.…”