Background Anovulation is one of the common causes of infertility. Polycystic ovary syndrome (PCOS) is the most common disorder with chronic Anovulation. To the best of our knowledge, insulin resistance relates significantly to PCOS. Therefore administration of insulin-sensitizing drugs such as pioglitazone can be used for ovulation stimulation in PCO patients. Methods After obtaining approval from the Ethics Committee of Mashhad University of Medical Sciences, 61 patients with PCOS were enrolled in the study based on inclusion/ exclusion criteria. Patients were divided into two groups. The first group received 30 mg (mg) of pioglitazone daily from the second day of the menstrual period. The second one received a placebo. 150 mg clomiphene citrate was administered from the third to the seventh day of the menstrual cycle. Vaginal sonography was performed in all women, and in cases with the mature follicle, intrauterine insemination was conducted after human chorionic gonadotropin injection. Ovary stimulation and pregnancy rate were compared between groups. Results There were no differences between groups regard to demographic characteristics and infertility type. Body mass index was higher in the pioglitazone group (28.3 ± 3.8 versus 26.2 ± 3.5, P value = 0.047). The size of the follicle was not significantly different between groups (2.2 ± 1.4 versus 1.3 ± 1.1, P value = 0.742). pregnancy rate [4 (12.9%) versus 4 (13.3%), P value = 1] had no differences between groups. Conclusion Although the number of follicles was higher in the pioglitazone group, our study showed no differences in ovary stimulation and pregnancy rate.

Introduction: ‏ Women are subject to extensive changes during menopause. ‏Life crises such as menopause can affect women's health and is a turning point in their lives. ‏The husbands are the most important and closest people who can support their wives in this evolutionary crisis with their correct understanding of the situation. ‏Objective: ‏This study aimed to determine the effectiveness of husbands' ‏awareness of the physical and psychological experiences of postmenopausal women. Materials and Methods: ‏This randomized clinical trial study was performed on ‎150 ‏married postmenopausal women in Kashmar City, Iran, in ‎2019. ‏The husbands of the intervention group received ‎three ‏sessions ‎(60 ‏minutes) ‏of the menopause training program with one-week intervals. ‏The spouses of both groups received routine care at the health center. ‏The questionnaire of psychological and physical experiences of postmenopausal women and measuring men's awareness of menopause in both groups was completed before the intervention and one month after the intervention. ‏The collected data were analyzed using descriptive statistics and inferential statistics of the Chi-square, ‏paired t test, ‏independent t test, and analysis of covariance. Results: ‏The mean ±SD age of women in the intervention group was ‎51.13 ±2.68 ‏years, and their mean ±SD menopausal age was ‎49.09 ±2.60 years. ‏The mean ±SD score of menopausal experiences before the intervention was ‎144.99 ±38.09 ‏in the intervention group and ‎143.47 ±28.48 ‏in the control group and ‎105.53 (35.41) ‏in the intervention group, and ‎118.82 (82.21) ‏in the control group. ‏The statistical test showed that the mean score of menopausal experiences and the range of adaptation after the intervention and also between the two groups have statistically significant differences with each other (P ‎= 0.001). Conclusion: ‏Menopause has adverse physical and psychological symptoms. ‏An intervention program to increase the awareness of men during menopause reduces negative menopausal experiences in women.