Frequency of human sperm carrying structural aberrations of chromosome 1 increases with advancing age

Sloter, Eddie D.; Marchetti, Francesco; Eskenazi, Brenda; Weldon, Rosana H.; Nath, J.; Cabreros, Debby; Wyrobek, Andrew J.

doi:10.1016/j.fertnstert.2006.08.112

Cited by 42 publications

(26 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15,20,21 There have been further reports using multicolor FISH in decondensed human sperm heads but each study has been limited to a particular chromosome. Using this approach, a positive age effect on the frequencies of duplications and deletions for the centromeric and subtelomeric regions of chromosome 9 was reported by Bosch et al 22 and, similarly, Sloter et al 23 found that sperm of older men carried more breaks and segmental duplications and deletions of chromosome 1.…”

Section: Introductionmentioning

confidence: 58%

See 1 more Smart Citation

Advanced age increases chromosome structural abnormalities in human spermatozoa

et al. 2010

View full text Add to dashboard Cite

This study explores the relationship between sperm structural aberrations and age by using a multicolor multichromosome FISH strategy that provides information on the incidence of duplications and deletions on all the autosomes. ToTelvysion kit (Abbott Molecular, Abbott Park, IL, USA) with telomere-specific probes was used. We investigated the sperm of 10 male donors aged from 23 to 74 years old. The donors were divided into two groups according to age, a cohort of five individuals younger than 40 and a cohort of five individuals older than 60 years. The goal of this study was to determine (1) the relationship between donor age and frequency and type of chromosome structural abnormalities and (2) chromosomes more frequently involved in sperm structural aberrations. We found that the older patients had a higher rate of structural abnormalities (6.6%) compared with the younger cohort (4.9%). Although both duplications and deletions were seen more frequently in older men, our findings demonstrate the presence of an excess of duplications versus deletions in both groups at a ratio of 2 to 1. We demonstrate that the distribution of duplications and deletions was not linear along the chromosomes, although a trend toward a higher rate of abnormalities in larger chromosomes was observed. This work is the first study addressing the frequencies of sperm chromosome structural aberrations of all autosomes in a single assay thus making a contribution to the clarification of the amount and origin of damage present in human spermatozoa and in relation to age.

show abstract

Section: Introductionmentioning

confidence: 58%

“…Along these lines, a positive age effect on the frequencies of duplications and deletions for chromosome 9 22 and for chromosome 1 23 was reported in FISH studies of spermatozoa. We demonstrate that distribution of duplications and deletions was not linear along the chromosomes.…”

Section: Discussionmentioning

confidence: 78%

Advanced age increases chromosome structural abnormalities in human spermatozoa

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Using sperm FISH analysis to demonstrate centromeric and subtelomeric regions, a significant association with donors' age was detected for the frequency of acentric fragments of chromosome 1 (P,0.05). 43 Sloter et al 44 have found that frequency of sperm with segmental duplications and deletions of chromosome 1 was twice among older men, and frequency of sperm carrying breaks within the 1q12 fragile site region nearly doubled.…”

Section: Structural Chromosomal Anomalies In Sperm Analysismentioning

confidence: 99%

Advanced paternal age and reproductive outcome

Wiener-Megnazi¹,

Auslender²,

Dirnfeld³

2011

Asian J Androl

102

View full text Add to dashboard Cite

Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.

show abstract

“…Whereas it is well established that women >35 years of age bear a higher risk of conceiving genetically abnormal offsprings [13,14], a correlation with paternal age is still at issue. For instance, Sloter et al, have shown that advancing male age is associated with a gradual and significant increase in the risk of fathering children with various chromosomal defects on a total of 320 unselected patients consulting their IVF and Urological Center [15]. In contrast, Luetjens et al [16] did not find a significantly higher risk of producing chromosomally abnormal offsprings for men of advanced age.…”

Section: Introductionmentioning

confidence: 98%

The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

Brahem

Mehdi

Elghezal

et al. 2011

J Assist Reprod Genet

107

View full text Add to dashboard Cite

Purpose To investigate the effects of male aging on semen quality, DNA fragmentation and chromosomal abnormalities in the spermatozoa of infertile patients and fertile men. Methods Semen samples of 140 infertile patients (24-76 years) and 50 men with proven fertility (25-65 years) were analyzed according to WHO guidelines. DNA fragmentation was detected by TUNEL assay, while aneuploidy was assessed by FISH. Results In the patient group, semen volume and vitality of spermatozoa decreased significantly with age, while sperm concentration showed a statistically significant increase with age. DNA fragmentation as well as disomy of sex chromosomes and disomy 8 did not show a statistically significant change with age. However, the diploidy rate was significantly increased with patient's age. In the control group, conventional semen parameters as well as DNA fragmentation and chromosomal abnormalities did not show a statistically significant with age. Conclusion Increased age in infertile men is associated with an increase in sperm concentration and diploidy, as well as a decline in semen volume and sperm vitality. However motility, morphology and DNA fragmentation are not affected by male age.

show abstract

Frequency of human sperm carrying structural aberrations of chromosome 1 increases with advancing age

Cited by 42 publications

References 71 publications

Advanced age increases chromosome structural abnormalities in human spermatozoa

Advanced age increases chromosome structural abnormalities in human spermatozoa

Advanced paternal age and reproductive outcome

The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

Contact Info

Product

Resources

About