Advanced paternal age and reproductive outcome

Wiener-Megnazi, Zofnat; Auslender, Ron; Dirnfeld, Martha

doi:10.1038/aja.2011.69

Cited by 101 publications

(79 citation statements)

References 106 publications

(114 reference statements)

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“…Paternal age has also been associated with methylation defects in sperm [30], the implications of which have yet to be elaborated. Telomere length, which is linked to age-associated diseases, may shorten more rapidly in males than females [23]. These studies support the possibility that increasing male age could lead to more frequent abnormalities in pregnancies and offspring.…”

Section: Discussionsupporting

confidence: 61%

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

Stern

Luke

Hornstein

et al. 2014

J Assist Reprod Genet

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Purpose To compare ages of mothers and of fathers at delivery in couples who are fertile, subfertile, and subfertile treated with assisted reproductive technology (ART) and to characterize birth outcomes in the ART population according to paternal age. Methods Live birth deliveries in Massachusetts between July, 2004 and December, 2008 were identified from vital records and categorized by maternal fertility status and treatment as ART, subfertile or fertile. The ART births were linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) database to obtain cycle-specific treatment data. Parental ages were obtained from birth certificates. Age of mothers and fathers were compared using ANOVA for continuous measures and χ 2 for categories. Risks of prematurity (<37 weeks), low birthweight (<2,500 g), and low birthweight z-score (small for gestatational age, SGA) were modeled using logistic regression by categories of paternal age as adjusted odds ratios and 95 % CI. Results The study population included 9,092 ART, 6,238 subfertile, and 318,816 fertile deliveries. Paternal ages in the ART and subfertile groups were similar and differed significantly from those of the fertile group. Maternal age in the ART and subfertile groups averaged 5-6 years older than their fertile counterparts and fathers averaged 4-5 years older with twice as many being older than 37. The risks for prematurity, low birthweight and SGA did not increase with increasing paternal age. Conclusions Fathers in ART-treated and subfertile couples are older than in their fertile counterparts. Older paternal age was not assoicated with increased risk for prematurity, low birthweight, or SGA.

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Section: Discussionsupporting

confidence: 61%

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

Stern

Luke

Hornstein

et al. 2014

J Assist Reprod Genet

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“…As improvements in reproductive technologies have pushed the frontiers of reproductive medicine, media reports of elderly men fathering children 1 have raised awareness and garnered acceptance of advanced paternal age (APA) in modern times. [1][2][3][4] Societal pressures are partly to blame for the trend of couples delaying childbearing well into their mid-to late-thirties. Careers and educational aspirations, along with an increased life expectancy and the nearly ubiquitous use of contraception, have decreased accidental birth rates and increased parental age at first childbirth.…”

Section: Introductionmentioning

confidence: 99%

The effects of advanced paternal age on fertility

Kovac¹,

Addai²,

Smith³

et al. 2013

Asian J Androl

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Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.

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“…Although males do not experience an expiry of reproductive functions, such as menopausal women do, their reproductive organs suffer gradual alterations that have a real impact on fertility [28]. With each passing decade the testis undergo several histomorphological changes associated with a hormonal dysregulation and cellular mass loss [12,29].…”

Section: Age Influence On Testicular Functionsmentioning

confidence: 99%

“…Furthermore, Sertoli and Leydig cells are also reduced in numbers and present noticeable cytoplasmic alterations, which influence the testes architecture [8,[35][36][37]. Although efforts have been made to define an age threshold for these changes, they seem to develop gradually throughout life and limits are yet to be defined [28].…”

Section: Age Influence On Testicular Functionsmentioning

confidence: 99%

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Rabaça¹,

Ferreira²

2016

Andrology(Los Angel)

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The rise in life expectancy and the desire to establish a stable career prior to parenthood leads couples to a delayed childbearing. Advanced parental age at the time of pregnancy portrays several risks, with the majority of couples above 35 experiencing reproductive impairments. While the effect of women's age on fertility is well known, the influence of paternal age is less understood. Thus, efforts have been made to comprehend the influence of APA on pregnancy upkeep and disease risk for the offspring. Over the last decades numerous studies aimed to establish the relationship between APA and male fertility potential. It has been found that APA is related to testicular and hormonal alterations, along with a decreased sperm production, quality and DNA integrity. As expected, these alterations compromise the reproductive potential of older men and have been associated with several fecundity problems, including increased time to pregnancy and abortion rates, and decreased fertilization and pregnancy rates. Additionally, alterations in offspring health, like genetic disorders, mental illnesses, congenital anomalies and cancer, have also been linked to APA. As a result, APA influence on the reproductive outcome must be taken into consideration when counseling couples attending family planning consultations or pursuing fertility treatments. Nonetheless, to date, there are still no definite results regarding this problem and an age threshold has yet not been established and additional research to better elucidate the effects of APA on fertility and offspring's health is needed. Likewise, establishing an age threshold for APA would be of great value to males thinking of delaying parenthood, and to physicians for medical advice purposes.

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Advanced paternal age and reproductive outcome

Cited by 101 publications

References 106 publications

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

The effects of advanced paternal age on fertility

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

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