Frequency of HLA antigen in asbestos workers with and without pulmonary fibrosis.

Evans, Cyril; Lewinsohn, Hilton C.; Evans, June M

doi:10.1136/bmj.1.6061.603

Cited by 31 publications

(10 citation statements)

References 5 publications

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“…DARKE et al [76] in a study of 78 diseased and 92 unaffected asbestos workers, also found an increase in the frequency of the B27 antigen, although this was nonsignificant. The association between the HLA-B27 gene and asbestosis was not confirmed in a study of 37 patients and 37 matched exposed controls by EVANS et al [77]. In addition, EVANS et al [77] found no association even when they combined their data with those of MATEJ et al [78].…”

Section: Fibrotic Lung Disordersmentioning

confidence: 93%

“…The association between the HLA-B27 gene and asbestosis was not confirmed in a study of 37 patients and 37 matched exposed controls by EVANS et al [77]. In addition, EVANS et al [77] found no association even when they combined their data with those of MATEJ et al [78]. EVANS et al [77] found, instead, that subjects with the HLA-B12 allele had more severe fibrosis.…”

Section: Fibrotic Lung Disordersmentioning

confidence: 94%

“…In addition, EVANS et al [77] found no association even when they combined their data with those of MATEJ et al [78]. EVANS et al [77] found, instead, that subjects with the HLA-B12 allele had more severe fibrosis. With the background that the B12 antigen had been found associated with cryptogenic fibrosing alveolitis, a disease similar to pulmonary asbestosis in the absence of asbestos exposure, they suggested that a gene in positive linkage disequilibrium with HLA-B12 could be responsible for the weak association observed.…”

Section: Fibrotic Lung Disordersmentioning

confidence: 94%

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Immunogenetic basis of environmental lung disease: lessons from the berylliosis model

Saltini¹,

Amicosante²,

Franchi³

et al. 1998

Eur Respir J

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The role of genetic factors has been hypothesized in the pathogenesis of a number of chronic inflammatory lung diseases. The genes of the major histocompatibility complex (MHC) locus on human chromosome 6 have been identified as important determinants in diseases caused both by inorganic and organic compounds such as beryllium, gold, acid anhydrides, isocyanates and grass pollens. Since many environmental factors are the determinants of the immunopathogenesis of asthma, pulmonary granulomatous disorders, hypersensitivity pneumonitis and fibrotic lung disorders, an understanding of the interaction between environmental factors is crucial to epidemiology, prevention and treatment of these disorders. Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of beryllium dusts. A human leukocyte antigen class II marker (HLA-DP Glu69) has been found to be strongly associated with the disease. In in vitro studies, the gene has been shown to play a direct role in the immunopathogenesis of the disease. In human studies, the gene has been shown to confer increased susceptibility to beryllium in exposed workers, thus suggesting that HLA gene markers may be used as epidemiological probes to identify population groups at higher risk of environmental lung diseases, to identify environmental levels of lung immunotoxicants that would be safe for the entire population and to prevent disease risk associated with occupation, manufactured products and the environment. Studies on the associations between human leukocyte antigens and chronic inflammatory lung disorders are reviewed in the context of the berylliosis model.

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Section: Fibrotic Lung Disordersmentioning

confidence: 93%

Section: Fibrotic Lung Disordersmentioning

confidence: 94%

Section: Fibrotic Lung Disordersmentioning

confidence: 94%

See 1 more Smart Citation

Immunogenetic basis of environmental lung disease: lessons from the berylliosis model

Saltini¹,

Amicosante²,

Franchi³

et al. 1998

Eur Respir J

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show abstract

“…Studies of genetic factors in man, in relation to asbestos, coal mine dust, or other inhaled mineral particles, have not yet shown convincing associations with an increased frequency of specific major histocompatibility complex antigens, now generally termed HLA (11,43,45). This failure may perhaps be due to the paucity of evidence so far accumulated (6), but even where the association between HLA and disease is the strongest known, ie, in ankylosing spondylitis, 10 % of Caucasian patients lack the diagnostic antigen B27.…”

Section: Additional Potential Susceptibility Factorsmentioning

confidence: 99%

Individual susceptibility to inhaled particles. A methodological essay.

Liddell¹,

Miller²

1983

Scand J Work Environ Health

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“…Table I shows the frequency of these antigens in the various groups and Table II (Evans et al, 1977), Northern Ireland (Middleton et al, 1978) and S.W.…”

mentioning

confidence: 99%

HLA-A and B antigen frequencies and mesothelioma in relation to asbestos exposure

Wagner¹,

Darke²,

Coles³

et al. 1983

Br J Cancer

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Frequency of HLA antigen in asbestos workers with and without pulmonary fibrosis.

Cited by 31 publications

References 5 publications

Immunogenetic basis of environmental lung disease: lessons from the berylliosis model

Immunogenetic basis of environmental lung disease: lessons from the berylliosis model

Individual susceptibility to inhaled particles. A methodological essay.

HLA-A and B antigen frequencies and mesothelioma in relation to asbestos exposure

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