Individual susceptibility to inhaled particles. A methodological essay.

Liddell, Douglas; Miller, K.

doi:10.5271/sjweh.2448

Cited by 32 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In principle, age and body build might bear on the prevalence of PMF (124), although by what means remains obscure; predictions were too prone to error to be of value. Furthermore, difficulties are inherent in gauging susceptibility by case-control or longitudinal studies of working populations exposed to inhaled particles (125). Similar considerations apply to animal experiments, whose human application may also be fraught with reservations.…”

Section: Cellular Responsesmentioning

confidence: 99%

Prevalence and pathogenesis of pneumoconiosis in coal workers.

Heppleston

1988

Environ Health Perspect

View full text Add to dashboard Cite

Dust dose and composition do not appear to account wholly for changes in the prevalence of coal workers' pneumoconiosis in Europe. In certain coal pits high progression evidently occurred with relatively low dust exposure or vice versa, whereas progression in relation to dust levels might be variable. Exceptionally high quartz concentrations occur in coal mine dust when pneumoconiosis may progress with unusual rapidity. Under such circumstances lesions resembling silicotic nodules may be found, but with the customarily lower levels of quartz the pathological features assume the form characteristic of coal workers. Morphological changes in relation to dust content of human and animal lungs, as well as cellular behavior, have not accounted completely for the epidemiological findings. Considering all the pathological evidence helps explain the pathogenesis of pneumoconiosis and vagaries of progression. The origin of progressive massive fibrosis cannot be explained simply in terms of dust burden or immunological features, and the role of an infective factor cannot be dismissed. Moreover, lipid secretion by alveolar epithelium introduces a new element that could affect the development of simple and complicated pneumoconiosis. In vitro, cytotoxicity appeared to be too variable for predictive purposes, though direct assay of fibrogenicity using the macrophage fibrogenic factor suggested that dust dose was more important than dust composition. Assessing individual susceptibility presents serious obstacles.

show abstract

Section: Cellular Responsesmentioning

confidence: 99%

Prevalence and pathogenesis of pneumoconiosis in coal workers.

Heppleston

1988

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…In principle, age and body build might bear on the prevalence of PMF (124), although by what means remains obscure; predictions were too prone to error to be of value. Furthermore, difflculties are inherent in gauging susceptibility by case-control or longitudinal studies of working populations exposed to inhaled particles (125). Similar considerations apply to animal experiments, whose human application may also be fraught with reservations.…”

Section: Commentmentioning

confidence: 99%

Prevalence and Pathogenesis of Pneumoconiosis in Coal Workers

Heppleston¹

1988

Environmental Health Perspectives

View full text Add to dashboard Cite

JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives.Dust dose and composition do not appear to account wholly for changes in the prevalence of coal workers' pneumoconiosis in Europe. In certain coal pits high progression evidently occurred with relatively low dust exposure or vice versa, whereas progression in relation to dust levels might be variable. Exceptionally high quarts concentrations occur in coal mine dust when pneumoconiosis may progress with unusual rapidity. Under such circumstances lesions resembling silicotic nodules may be found, but with the customarily lower levels of quart the pathological features assume the form characteristic of coal workers. Morphological changes in relation to dust content of human and animal lungs, as well as cellular behavior, have not accounted completely for the epidemiological findings. Considering all the pathological evidence helps explain the pathogenesis of pneumoconiosis and vagaries of progression. The origin of progressive massive fibrosis cannot be explained simply in terms of dust burden or immunological features, and the role of an infective factor cannot be dismissed. Moreover, lipid secretion by alveolar epithelium introduces a new element that could affect the development of simple and complicated pneumoconiosis. In vitro, cytotoxicity appeared to be too variable for predictive purposes, though direct assay of fibrogenicity using the macrophage fibrogenic factor suggested that dust dose was more important than dust composition. Assessing individual susceptibility presents serious obstacles.

show abstract

“…ular study, they confessed to violating dust control reg? tors of vulnerability should be considered separately (2). On the other hand, such exposure differences are not likely to be responsible for all variations.…”

mentioning

confidence: 99%