Frequency of Helicobacter pylori and CagA Antibody in Patients with Gastric Neoplasms and Controls: The Indian Enigma

Ghoshal, Uday C; Tiwari, Shridhar; Dhingra, Sadhna; Pandey, Rakesh; Ghoshal, Ujjala; Tripathi, Shweta; Singh, Harpreet; Gupta, Vishal; Nagpal, Angela; Naik, Sita; Ayyagarí, A

doi:10.1007/s10620-008-0229-7

Cited by 45 publications

(37 citation statements)

References 34 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2004, other authors reported a prevalence of H. pylori infection in 56% of dyspeptic patients from Karachi [43]; however, in early 2000, Taj et al reported seroprevalence of H. pylori in 80% of the cases from the city [27]. Our report and another from Yakoob et al confirm the decreasing trend of H. pylori infection overtime in Karachi, which is comparable to trends seen in other South Asian and European countries [44][45][46]. Interestingly, earlier studies from northern and central parts of Pakistan reported 66% and 84% prevalence rates among dyspeptic patients [25,29], indicating the difference in H. pylori infection in geographic niches and ethnic groups in Pakistan.…”

Section: Discussionsupporting

confidence: 85%

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Khan

Farooqui

Raza

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes and their association with different clinical outcomes among dyspeptic patients in Pakistan over a period of four years. Methodology: Gastric biopsy samples from a total of 450 dyspeptic individualswere subjected to PCR, genotypingand histology. Results: A total of 201 (45%) cases were found positive for H. pylori. The detection rate was high in GU (91%), DU (86%) and GC (83%) cases compared with those cases who had intact gastric mucosa (18%). Histology revealed the presence of infection in 68% of cases of mild/chronic nonspecific gastritis with others belonging to the GU sequel. cagA gene carriage was observed in 104 (51%) cases or mostly from DU, GU and GC groups, of which 97 were Western type strains while 3 were East-Asian type strains that are rarely observed in South Asia. vacA allelic variant s1am1 was most commonly observed, followed by s1am2, and s1bm1, with direct correlation in diseased cases (gastritis, GU, DU and GC). Prevalent genotypic combinations were s1am1/cagA -in gastritis and s1am1/cagA + in DU, GU, and GC. Conclusions: Our study indicates the predominant circulation of Western type cagA and vacAs1am1 type H. pylori strains in Pakistan.

show abstract

Section: Discussionsupporting

confidence: 85%

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Khan

Farooqui

Raza

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Almost 50% to 80% of the world's population infected with H.pylori, but only 1% of them developed gastric cancer (Graham et al, 1991;Parsonnet et al, 1997), which suggested the host genetic and environmental factors may modulate the risk of gastric cancer in association with H.pylori infection (Singh et al, 2006;Ghoshal et al, 2008;Ghoshal et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Yang¹,

Zhang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphisms in combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newly diagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>T and rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147 CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258 TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258 TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CC was associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findings suggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, but the effect needs to be further validated by larger sample size studies.

show abstract

“…Almost 50% to 80% of the world's population infected with H.pylori, but only 1% of them developed gastric cancer (Graham et al, 1991;Parsonnet et al, 1997). This suggested the host genetic and environmental factors may modulate the risk of gastric cancer in association with H.pylori infection (Singh et al, 2006;Ghoshal et al, 2007;Ghoshal et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Glulathione-S-transferases Gene Polymorphism in Prediction of Gastric Cancer Risk by Smoking and Helicobacter Pylori Infection Status

Chen¹,

Huang²,

Duan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Aim: To evaluate the association of glutathione S-transferases gene polymorphisms with the risk of gastric cancer, with reference to smoking and Helicobacter pylori infection. Methods: We conducted a 1:1 matched casecontrol study with 410 gastric cancer cases and 410 cancer-free controls. Polymorphisms of GSTM1, GSTT1 and GSTP1 were determined using PCR-CTPP. Results: The GSTM1 and GSTT1 null genotypes were significantly associated with the risk of gastric cancer after adjusting for potential confounding factors (OR=1.68, 95% CI=1.32-2.23 for null GSTM1, OR=1.73; 95% CI=1.24-2.13 for null GSTT1). The combination of null GSTM1 and null GSTT1 conferred an elevated risk (OR=2.54, 95% CI=1.55-3.39). However, no association was found for GSTP1 polymorphism The smoking modified the association of GSTM1 and GSTT1 null genotypes with the risk of gastric cancer. Conclusion: GSTM1 and GSTT1 null genotypes are associated with increased risk of gastric cancer, and smoking modifies the association.

show abstract

Frequency of Helicobacter pylori and CagA Antibody in Patients with Gastric Neoplasms and Controls: The Indian Enigma

Abstract: Frequency of H. pylori as detected using endoscopy and serology-based tests is not higher among patients with GN as compared with controls in India.

Cited by 45 publications

References 34 publications

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Glulathione-S-transferases Gene Polymorphism in Prediction of Gastric Cancer Risk by Smoking and Helicobacter Pylori Infection Status

Contact Info

Product

Resources

About