Frequency of gall bladder metaplasia and its distribution in different regions of gall bladder in routine cholecystectomy specimens

Sharma, Renu; Chander, Bal; Kaul, Rashmi; Rattan, Amit; Sood, Anuradha; Sharad, Kavita; Khajuria, Meenakshi

doi:10.18203/2320-6012.ijrms20175559

Cited by 3 publications

(5 citation statements)

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“…We noted that pyloric metaplasia was more common than other types of metaplasia, which is comparable to previous studies (30,(32)(33)(34). The mean age of the patients with pyloric and intestinal metaplasia was 51.1 and 52.55 years, respectively.…”

Section: Discussionsupporting

confidence: 92%

“…Gallbladder polyps were detected in 0.6% of the patients with higher frequency in women; although Aldouri et al (27) In this study, intestinal and pyloric metaplasia were seen in 2.92% and 16.43% of the cases, respectively. Although, Sharma et al (30) reported intestinal metaplasia in 15.97% and pyloric metaplasia in 42.86% of gallbladders. The prevalence of intestinal and pyloric metaplasia in Segovia Lohse and Cuenca Torres's (31) study was reported 2.1% and 22.6%, respectively.…”

Section: Discussionmentioning

confidence: 95%

“…These results were in accordance with previous studies (33,35,36); intestinal metaplasia and pyloric metaplasia were observed in patients over 50 years old. Sharma et al (30) illustrated that pyloric and intestinal metaplasia were observed in patients with a mean age of 42.5 and 43 years, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Histopathologic Features of 1000 Cholecystectomy Specimens

et al. 2020

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Background: One of the most common gastrointestinal surgeries is cholecystectomy. Gallstones are the major causes of cholecystectomy and induce various histopathologic changes. Gallbladder carcinoma is rare with poor prognosis. Metaplasic changes in gallbladder epithelium are considered precancerous lesions. Objectives: This study aimed at revealing the spectrum of histopathological patterns of gallbladder diseases in cholecystectomy specimens. Methods: A total of 1004 gallbladder H & E stained slides of cholecystectomy specimens over one year were studied. Histopathological evaluation was done by 6 pathologists in terms of variables. Results: In our study, the male: female ratio was 1:2.1. The age of patients varied from 17 to 96 years with a mean age of 49.1 years. The mean age of patients with gallstones was 47.52 years and was more common in women. Cholesterol, pigmented, and mixed stones were reported in 58.36%, 39.03%, and 2.6% of gallstones, respectively. The most common histological morphology was chronic calculous cholecystitis (61.18%). The incidence of metaplasia and invasive carcinoma was 19.55% and 0.2%, respectively. Conclusions: In this study, histopathological analysis of gallbladder diseases in the cholecystectomy specimens revealed that chronic calculous cholecystitis was the most common histologic finding. Gallstones were found more commonly in women and cholesterol stone was the predominant type. Pyloric metaplasia was the most frequent type of metaplasia. The rate of invasive carcinoma is compatible with those reported in the literature. Routine histopathological analysis of the cholecystectomy specimens will help to detect incidental carcinoma and precursors of malignancy.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 95%

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Histopathologic Features of 1000 Cholecystectomy Specimens

et al. 2020

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“…Renu Sharma et al 2018 reported metaplasia in 42.5% of pyloric, 16% of intestinal metaplasia. 6 16.5% of pyloric and 15.5% of intestinal metaplasia by Khanna et al 2006. 7 50% of pyloric and 16% intestinal metaplasia by Martinezguzman et al 8 Highest incidence of 95.1% of pyloric metaplasia and 58.1% of intestinal metaplasia by Duarte et al 1993.…”

Section: Discussionmentioning

confidence: 97%

Clinicopathological study of calculous cholecystitis

Sarvani¹,

Kumar²,

Swathi³

et al. 2021

ACHR

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Calculous cholecystitis is the most common lesion of the gallbladder. Pain abdomen is the common clinical presentation.Calculous and acalculous cholecystitis are the most common indications for cholecystectomy. Gross and microscopic examination of the gall bladder indicates the outcome of the lesions. The various histological findings will reveal the type of the disease entity and prognosis. Retrospective study was done, total 120 cases of cholecystectomy specimens were received in pathology department. Formalin fixed specimens were analysed. After processing, H&E stained sections were studied.Chronic calculous cholecystitis is the most common non-neoplastic lesion. calculous cholecystitis(92 cases), acalculous cholecystitis (21 cases), follicular cholecystitis (4 cases), empyema gallbladder (1 case), xanthogranulomatous cholecystitis (1 case), eosinophilic cholecystitis (1 case). Among premalignant lesions, cholecystitis with metaplasia was seen in 40 (33.3%) cases. Pyloric metaplasia (25 cases), Intestinalmetaplasia (15 cases). Chronic calculous cholecystitis was the most common lesion. Histopathological evaluation plays an important role in identifying the metaplastic, dysplastic and incidental carcinoma of the gallbladder. .

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“…Similar findings were observed by Baig SJ et al [24] and Tyagi SP et al [25] they found chronic cholecystitis in 60% and 50.8% cases respectively. Acute cholecystitis accounted for 6.45% cases while Kaur et al [26] Khan S et al [27] and Sharma I et al [28] showed 2.60%, 2.70% and 2.60% cases of acute cholecystitis respectively. Cholesterolosis was seen in only 31 cases (7.14%) which was similar to the work done by Giri S et al [18] who reported cholesterolosis in 7.61% cases.…”

Section: Discussionmentioning

confidence: 99%

The spectrum of histopathological lesions in Gallbladder in cholecystectomy specimens

Gupta¹,

Faiz²,

Thakral³

et al. 2019

Int. J. Clin. Diagn. Pathol.

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Background: Gall bladder is very common organ to be affected by many pathological diseases which include wide spectrum of the lesions from congenital ones to inflammatory or premalignant and malignant lesions. Aim: Study the spectrum of histopathological lesions in gallbladder in Cholecystectomy specimens. Material and Methods: The study was conducted in the Department of Pathology, Muzaffarnagar Medical College, Muzaffarnagar. Total of 434 cholecystectomy specimen were studied. Result: Maximum cases (231/434 cases) were of chronic cholecystitis followed by acute cholecystitis (28 cases), eosinophilic cholecystitis (3 cases), cholesterolosis (31 cases), follicular cholecystitis (11 cases), xanthogranulomatous cholecystitis (9 cases) and one case each of mucocele and porcelain gall bladder. Metaplasia was seen in 83 cases (19.12%), dysplasia in 16 cases (3.68%) and malignancy in 5 cases (1.15%). Conclusion: Gall bladder with stones of prolonged duration associated with risk of premalignant and malignant conditions making histopathological examination necessary for timely recognization of lesion.

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Frequency of gall bladder metaplasia and its distribution in different regions of gall bladder in routine cholecystectomy specimens

Cited by 3 publications

References 2 publications

Histopathologic Features of 1000 Cholecystectomy Specimens

Histopathologic Features of 1000 Cholecystectomy Specimens

Clinicopathological study of calculous cholecystitis

The spectrum of histopathological lesions in Gallbladder in cholecystectomy specimens

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