Frequency of Early-onset Neonatal Sepsis Following Prolonged Rupture of Membranes

Rathore, Heeranand; Rahman, Arshalooz Jamila; Salman, Muhammad; Nasir, Muhammad; Sherali, Seharish

doi:10.7759/cureus.6864

Cited by 9 publications

(10 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18,21,22 Early membrane rupture increases the risk of bacteria rising from the birth canal into the amniotic sac, resulting in chorioamnionitis and fetal compromise, as well as hypoxia, which usually leads to sepsis. 23 This research also discovered a link between neonatal sepsis and neonatal resuscitation. The odds of developing neonatal sepsis among neonates who had a history of neonatal resuscitation at birth were 2.3 times higher as compared to neonates who had not been resuscitated.…”

mentioning

confidence: 92%

Neonatal Sepsis and Associated Factors Among Newborns in Woldia and Dessie Comprehensive Specialized Hospitals, North-East Ethiopia, 2021

Birrie¹,

Chanie²,

Tibebu³

et al. 2022

IDR

View full text Add to dashboard Cite

Neonatal sepsis is a clinical illness characterized by infection-related signs and symptoms in the first month of life, with or without bacteremia. Septicemia, meningitis, pneumonia, arthritis, osteomyelitis, and urinary tract infections are all examples of systemic illnesses that can affect newborns. Hence, the main aim of this study was to assess the prevalence and factors associated with neonatal sepsis among newborns in Woldia and Dessie Comprehensive Specialized Hospitals, northeast Ethiopia, from January 1 to July 30, 2021. Methods: This institution-based cross-sectional study was conducted from January 1 to July 30, 2021, on 344 randomly selected neonates who visited the hospital. A systematic random sampling technique was used to select samples, and data were collected using a pre-tested standardized questionnaire. For data entry and analysis, Epi Data version 4.1 and SPSS version 24 applications were used, respectively. The goodness-of-fit was tested by the Hosmer-Lemeshow statistic test. Bivariable and multivariable binary logistic regressions were used to identify associated factors at a 95% confidence interval. Significance was considered at p-value <0.05. Results: In this study, the prevalence of neonatal sepsis was 79.4% (95% CI: 75.2-83.6%). Maternal UTI/STI history [AOR: 3.1; 95% CI (1.5-7.1)], gestational age <37 weeks [AOR: 4.4; 95% CI (1.0-8.9)], PROM [AOR: 4.9; 95% CI (2.5-6.8)], and new-born resuscitation history [AOR: 2.3; 95% CI (1.5-4.3)] were all significantly associated with neonatal sepsis. Conclusion:This study indicates that the proportion of neonatal sepsis is high. A history of maternal PROM, being a preterm neonate, a history of maternal UTI/STIs, and having received resuscitation at birth were identified as risk factors for neonatal sepsis.

show abstract

mentioning

confidence: 92%

Neonatal Sepsis and Associated Factors Among Newborns in Woldia and Dessie Comprehensive Specialized Hospitals, North-East Ethiopia, 2021

Birrie¹,

Chanie²,

Tibebu³

et al. 2022

IDR

View full text Add to dashboard Cite

show abstract

“…No presente estudo, cerca de 43% dos neonatos apresentaram esse achado, que não foi associado a maior frequência de óbito. Quando ocorre a ruptura precoce da membrana, a incidência de sepse aumenta (Rathore et al,2020). Considerando a utilização prévia de antimicrobianos durante a gestação, 35% das gestantes utilizaram antimicrobianos, mas esse uso não se mostrou relevante para indicar maior mortalidade.…”

Section: Discussionunclassified

Caracterização dos fatores de risco e ocorrência de óbito em recém-nascidos com diagnóstico de sepse neonatal em uma Unidade de Terapia Intensiva Neonatal

Oliveira

Boa‐Sorte

2022

RSD

View full text Add to dashboard Cite

A sepse neonatal é uma das principais causas de morte de recém-nascidos. O conhecimento prévio dos fatores de risco são fundamentais para prevenir a morbimortalidade. Este estudo tem como objetivo caracterizar os fatores de risco observados e sua relação com a ocorrência de óbito em recém-nascidos com diagnóstico de sepse. Realizou-se um estudo transversal com análise de 712 participantes internados no período de setembro de 2018 a junho de 2020. Foram incluídos 410 neonatos sendo de maior proporção os do sexo masculinos, nascidos com via de parto artificial e baixo peso. A prevalência de óbito observada foi de 6,3% sendo significativa especialmente entre os com prematuridade moderada e extrema, os nascidos de mães adolescentes ou com mais idade de 40 anos, os com hipertemia, baixo peso, bradicardia e maiores tempo de internamento. Encontrou-se uma baixa frequência de hemocultura realizadas. Embora não tenha sido observado predomínio dos achados clínicos característicos da sepse como hipotermia, alterações do leucograma, contagem de plaquetas e níveis de PCR, os achados robustos de maior associação de extremo baixo peso ao nascer, hipertermia e taquipneia a maior frequência de óbito reforçam a qualidade dos dados obtidos.

show abstract

“…Interestingly, Zurek et al uncovered a mechanism by which Staphylococcus aureus could inhibit the early neutrophil-derived IL-8 response and enhance infection (25). Another study on sepsis-associated neonatal mortality in developing countries reported that 3.2% of neonates with a maternal history of PROM developed early-onset neonatal sepsis, with group B streptococcus and Staphylococcus aureus positively detected (26). It is clear that Streptococcus, Chlamydia, and Staphylococcus are strongly related to infection and PROM in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…All study participants underwent regular prenatal examination according to the World Health Organization's antenatal care guidelines (i.e., initial examination within the first 12 gestational weeks, with subsequent follow-ups at 20,26,30,34,36,38, and 40 gestational weeks). Vaginal swabs were collected at the posterior fornix between 31 and 36 weeks of gestation, and the swabs were stored at −80 ℃ immediately after sampling.…”

Section: Prenatal Examination and Deliverymentioning

confidence: 99%

Integrated metagenomics and metabolomics analysis of third-trimester pregnant women with premature membrane rupture: a pilot study

Liu¹,

Chen²,

Chen³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: Premature rupture of membranes (PROM) is a major pregnancy complication in China and usually leads to adverse pregnancy outcomes. The major aim of this study was to search for microorganisms and their related metabolites that have direct relationship with PROM.Methods: For vaginal discharge samples, metagenomics sequencing was applied to identify microorganisms that were enriched in PROM subjects, and untargeted metabolomics was applied to characterize the metabolites changes in PROM subjects compared to healthy controls (HC). Correlation analysis was then used to explore the relationship between these microorganisms and metabolites changes.Results: Two upstream metabolites of glycolysis, N-acetyl-D-galactosamine (GalNAc) and sucrose, were found downregulated in the PROM group (P=0.004 and P=0.041, respectively). Higher percentages of conditional pathogens, such as of Streptococcus (8.4% vs. 6.1% in HC group, P=0.15) and Chlamydia (4.3% vs.2.3% in HC group, P=0.07) were found in PROM group. Other common conditional pathogens including Prevotella, Staphylococcus, Mycobacterium and Enterobacter, were also higher in PROM group, although their absolute percentages were low and the differences did not reach statistical significance due to relative small sample size. Correlation analysis further demonstrated a positive correlation of downregulation of glycolysis metabolites with higher percentage of conditional pathogens.Conclusions: Integrated metagenomics and metabolomics analysis can be used to track the subtle changes in the vaginal microenvironment. Downregulation of glycolysis substrates (GalNAc and sucrose) and increase of related pathogenic microorganisms (Streptococcus and Chlamydia) could serve as early warning biomarkers of PROM.

show abstract

Frequency of Early-onset Neonatal Sepsis Following Prolonged Rupture of Membranes

Cited by 9 publications

References 9 publications

Neonatal Sepsis and Associated Factors Among Newborns in Woldia and Dessie Comprehensive Specialized Hospitals, North-East Ethiopia, 2021

Neonatal Sepsis and Associated Factors Among Newborns in Woldia and Dessie Comprehensive Specialized Hospitals, North-East Ethiopia, 2021

Caracterização dos fatores de risco e ocorrência de óbito em recém-nascidos com diagnóstico de sepse neonatal em uma Unidade de Terapia Intensiva Neonatal

Integrated metagenomics and metabolomics analysis of third-trimester pregnant women with premature membrane rupture: a pilot study

Contact Info

Product

Resources

About