Frequency of congenital birth defects in newborn babies born at Hyderabad, Sindh.

Abstract

Objectives: This study has been conducted in a tertiary care hospital to observe the frequency of congenital birth defects in newborn babies born at, Hyderabad, Sindh. Study Design: Prospective observation study. Setting: The Departments of Obstetrics and Pediatrics, Isra University Hospital, Hyderabad. Period: Two years from 2016 to 2018. Material & Methods: All the pregnant women irrespective of their parity and were included in the study after getting informed and written consent from their family heads and after the approval from Hospital’s ethical committee. We have used SPSS version 21.0 software for both data entering and analysis. All the continuous variables were analyzed using student t test and categorical variables were analyzed using chi-square test. P-value of ≤0.05 was taken as statistically significant. Results: A total of 150 pregnant women were included in our study with their mean age and SD was 26.72 ± 7.07 years and the mean years of marriage were 5.95±6 years. Most of the women were multiparous (47%), as compared to nulliparous and grandmultiparous, 33% and 20%, respectively. The prevalence of congenital birth defect was 11.3%, of these 30% had CNS malformations followed by 30% with gastrointestinal, 24% musculoskeletal, 12% genitourinary and 4% had ear malformations. Conclusion: The interfamily marriages (consanguineous marriages) are more common than outside family in study population. The frequency of birth defects was more than i-e: twice higher in interfamily marriages than outside family marriages.

The Impact of Environmental Pollution on Congenital Anomalies of New Birth in Kirkuk City – Iraq

“…Additionally, several genetic changes and mutations are anticipated as a result of the deployment of chemical weapons starting with the second Gulf War. [16] Cousin marriage increase the risk of CA by 1.54 in current study population that agreed with previous studies [36][37][38]. The homozygous expression of recessive genes acquired from their common ancestors is most likely the cause of the increased occurrence of genetic abnormalities in the kids of consanguineous marriages.…”

Prevalence of Congenital Birth Defects among Pediatric Patients of Interior Punjab

“…Asendi et.al found the gastrointestinal disorders as the most common birth defect followed by neurological disorders (14) . Current findings are also supported by another study from spain (13) .…”

“…conducted a study in Karachi and found that the neural tube defects are the most commonly occurring congenital anomaly with prevalence of 65% (15) . Another study done in interior done in interior Sindh reported 11.3% cases of congenital abnormalities, out of which majority cases were of CNS and GIT malformations (13) .…”

“…Due to the current burden of disease, multiple researches are going on to minimize the incidence rate of congenital birth defects by inventing new medical technologies for early diagnosis so that preventive measures can be taken before time (12) . Early detection of congenital anomalies is not easy in developing countries, because of lack of facilities so prevalence rate is rising day by day as compared to developed countries (13) . The current study is important to highlight the prevalence of congenital birth defect and results showed its about 14.7%, comparing with another study done in Pakistan reported prevalence of 11.3% in 2019 (13) .…”

“…Early detection of congenital anomalies is not easy in developing countries, because of lack of facilities so prevalence rate is rising day by day as compared to developed countries (13) . The current study is important to highlight the prevalence of congenital birth defect and results showed its about 14.7%, comparing with another study done in Pakistan reported prevalence of 11.3% in 2019 (13) . This is an alarming situation that the prevalence of congenital birth defects rises to 1% per year from 2019 to 2022 which is an economical burden.…”