Frequency of climbing behavior as a predictor of altered motor activity in rat forced swimming test

Vieira, Cintia Teixeira; Lima, Thereza Christina Monteiro de; Carobrez, A.P.; Oliveira, Cilene Lino de

doi:10.1016/j.neulet.2008.09.001

Cited by 30 publications

(16 citation statements)

References 14 publications

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“…These data support the hypothesis that chronic systemic DEX treatment increases despair-based depressive-like behaviors in mice. However, decreased climbing behavior might have been associated with motor abnormalities (Lino- de-Oliveira et al, 2005;Vieira et al, 2008). Furthermore, in this study, animals treated chronically with dexamethasone showed a severe loss of body weight, which is a characteristic frequently observed in depression in both humans and animals (Stunkard et al, 1991;Parker et al, 2003;Feng et al, 2009;Sigwalt et al, 2011).…”

Section: Discussionmentioning

confidence: 55%

Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: Relevance to depression

et al. 2015

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Section: Discussionmentioning

confidence: 55%

Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: Relevance to depression

et al. 2015

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“…2C), indicating that 50 mg/kg BER administration decreased depression-like behavior. We next focused on "climbing behavior" [14]. Rats in the BER50 group had significantly restored climbing behavior during the 5 min in the FST compared with those in the MOR group (p<0.05; Fig.…”

Section: Resultsmentioning

confidence: 99%

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Lee

Sur

Yeom

et al. 2012

Korean J Physiol Pharmacol

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The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression-and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic morphine withdrawal in rats. Male rats were exposed to chronic, intermittent, escalating morphine (10∼ 50 mg/kg) for 10 days. After the last morphine injection, depression-and anxiety-like beahvior associated with morphine discontinuation persisted for at least three days during withdrawal without any change in ambulatory activity. Daily BER administration significantly decreased immobility in the forced swimming test and increased open-arm exploration in the elevated plus maze test. BER administration also significantly blocked the increase in hypothalamic CRF expression and TH expression in the locus coeruleus (LC) and the decrease in hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression. Taken together, these findings demonstrated that BER administration significantly reduced morphine withdrawal-associated behaviors following discontinuation of repeated morphine administration in rats, possibly through modulation of hypothalamic CRF and the central noradrenergic system. BER may be a useful agent for treating or alleviating complex withdrawal symptoms and preventing morphine use relapses.

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“…The loading of "duration of swimming" led to the classification of the second component as "putative SSRI" (Detke et al, 1995(Detke et al, , 1997Lino-de-Oliveira et al, 2005). The third component (putative motor) comprised the variables reported as related to the locomotor activity such as frequency of immobility and climbing (Lino-de-Oliveira et al, 2005;Vieira et al, 2008). Similar criteria applied to the factorial analysis of retest 1 or retest 2 generated two different antidepressant components and suppressed the third component.…”

Section: Discussionmentioning

confidence: 99%

“…This component (Table 2) has been named putative SSRI because duration of immobility and swimming has been changed following the treatment with selec- tive serotonin reuptake inhibitors (SSRI) (Detke et al, 1997;Lucki, 1997;Cryan et al, 2005a). Component III (Table 2), named putative motor component (Lino-de-Oliveira et al, 2005;Vieira et al, 2008), contained the frequency of immobility (EV = −0.6) and climbing (EV = −0.9). The factorial analysis of retest 1 or retest 2 (S1) produced a two-factor profile accounting for 71% or 80% of the total variance, respectively.…”

Section: Experiments 1: the Extraction Of The Principal Components In mentioning

confidence: 99%

Repeated rat-forced swim test: Reducing the number of animals to evaluate gradual effects of antidepressants

Mezadri

Batista

Portes

et al. 2011

Journal of Neuroscience Methods

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The forced swim test (FST) is a pre-clinical test to short and long term treatment with antidepressant drugs (ADT), which requires between-subject designs. Herein a modified protocol of the FST using within-subject design (repeated rat-FST) was evaluated. Male Wistar rats were submitted to 15 min of swimming (Day 1: pretest) followed by three subsequent 5 min-swimming tests one week apart (Day 2: test, Day 7: retest 1, Day 14: retest 2). To determine the temporal and factorial characteristics of the variables scored in the repeated rat-FST, the protocol was carried out in untreated animals (E1). To validate the method, daily injections of Fluoxetine (FLX, 2.5mg/kg, i.p.) or saline were given over a 2-week period (E2). Tests and retests have been videotaped for further register of the latency, frequency and duration of behaviors. Over retesting the latency to immobility decreased whereas duration of immobility tended to increase. Factorial analysis revealed that the test, the retest 1 as well as the retest 2 have variables suitable to detection of antidepressant-like effects of ADT. Compared to saline, FLX chronically administrated reduced duration of immobility whereas increased duration of swimming in retest 2. The data suggest that repeated rat-FST detected the gradual increase in the efficacy of low doses of FLX over time. Therefore, repeated rat-FST seemed suitable to detect short and long term effects of selective serotonin reuptake inhibitors, or other ADT, thus reducing the number of animals used in the screenings of this type of compounds.

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Frequency of climbing behavior as a predictor of altered motor activity in rat forced swimming test

Cited by 30 publications

References 14 publications

Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: Relevance to depression

Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: Relevance to depression

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Repeated rat-forced swim test: Reducing the number of animals to evaluate gradual effects of antidepressants

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