Frequency of autoimmune disorders and autoantibodies in patients with neuromyelitis optica

Pereira, Wildéa Lice de Carvalho Jennings; Reiche, Edna Maria Vissoci; Kallaur, Ana Paula; Oliveira, Sayonara Rangel; Simão, Andréa Name Colado; Lozovoy, Marcell Alysson Batisti; Schiavão, Lucas José Vaz; Rodrigues, Paula Raquel do Vale Pascoal; Alfieri, Daniela Frizon; Flauzino, Tamires; Kaimen-Maciel, Damacio Ramón

doi:10.1017/neu.2016.49

Cited by 35 publications

(17 citation statements)

References 56 publications

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“…Additionally, African-Americans with NMO at our institution had a higher female:male distribution than has been documented [3]. Not surprisingly, SLE was the most common associated systemic rheumatic disease in our cohort, however the frequency of SLE and ANA positivity in our NMO cohort was higher than has been reported (23.8% and 78.6%, respectively) [4]. Additional larger studies are needed to further explore how NMOSD in African-Americans may differ from other populations.…”

contrasting

confidence: 45%

Fri0582 non-Infectious Uveitis as a Manifestation of the Immune Reconstitution Inflammatory Syndromein Patients Infected by Hiv

Carreño

Torres

Muñoz

et al. 2019

Other Orphan Diseases

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BackgroundImmune reconstitution inflammatory syndrome (IRIS) is a paradoxical clinical worsening of an already known condition or the new onset of an inflammatory manifestation that is presumably related with the immune reconstitution after starting highly active anti-retroviral therapy (HAART) in patients infected by the human immunodeficiency virus (HIV).ObjectivesThe aim of this study is to describe the clinical characteristics, presentation and response to immunosuppressive treatment in patients with uveitis secondary to ocular IRIS in our cohort of patients infected by HIV.MethodsRetrospective review of clinical charts of patients diagnosed with HIV and non-infectious uveitis. Data collected included: demographics, anatomic classification of the uveitis, phenotypic diagnosis of the uveitis, other systemic immune-mediated disorders (IMD), time from HIV diagnosis to uveitis, CD4 count, viral load, treatment and complications of treatment and time of follow-up.ResultsNine-teen patients (17 males) were included in the study. The mean age at the time of HIV diagnosis was 35.4±9.6 years. The time lag between HIV diagnosis and the onset of uveitis was 9±8.9 years. Mean CD4 count was 649±292 cells/ml, while the viral load was undetectable in 13 out of 17 cases. In 2 patients, there were a worsening of a previous IMD and in 6 patients another IMD was diagnosed prior to or concurring with the uveitis diagnosis (3 cases of reactive arthritis). The most common anatomic classification of the uveitis was anterior (13 cases). The use of immunosuppressive therapies to control either the ocular syndrome or the additional IMD was necessary in 6 patients (including biologics in 4 cases) during the follow-up. Only one patient had a complication of the immunosuppressive treatment. The mean follow-up was 43.8 months (range: 0.6 -115.7).ConclusionNon-infectious uveitis could be the first manifestation of immune-mediated systemic disease in patients with well-controlled HIV infection. Immunosuppression appeared to be a safe therapeutic option in our cohort of patients.References[1] Shelburne SA, 3rd, Hamill RJ, Rodriguez-Barradas MC, et al. Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore)2002;81(3):213-27. [published Online First: 2002/05/09][2] Murdoch DM, Venter WD, Van Rie A, et al. Immune reconstitution inflammatory syndrome (IRIS): review of common infectious manifestations and treatment options. AIDS Res Ther2007;4:9. Doi: 10.1186/1742-6405-4-9 [published Online First: 2007/05/10][3] Vega LE, Espinoza LR. HIV infection and its effects on the development of autoimmune disorders. Pharmacol Res2018;129:1-9. Doi: 10.1016/j.phrs.2018.01.005 [published Online First: 2018/01/15][4] Sokoya T, Steel HC, Nieuwoudt M, et al. HIV as a Cause of Immune Activation and Immunosenescence. Mediators Inflamm2017;2017:6825493. Doi: 10.1155/2017/6825493 [published Online First: 2017/12/07][5] Yeo TH, Yeo TK, Wong EP, et al. Immune recovery uveitis in HIV pa...

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contrasting

confidence: 45%

Fri0582 non-Infectious Uveitis as a Manifestation of the Immune Reconstitution Inflammatory Syndromein Patients Infected by Hiv

Carreño

Torres

Muñoz

et al. 2019

Other Orphan Diseases

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“…In a cohort study conducted in Brazil, among 22 NMO patients, with 68.2% being Afro-Brazilians, 27.3% of them had other autoimmune disorders including autoimmune thyroid disease (n=3,13.5%), juvenile idiopathic arthritis (n = 1), systemic lupus erythematosus and systemic sclerosis (n = 1), and Raynaud"s phenomenon (n = 1). Furthermore, the most frequently reported autoantibodies included anti-nucleosome (ANuA) (31.8%), ANA (27.3%), anti-TPO (22.7%), and anti-Tg (22.7%) [163].…”

Section: Accepted Manuscript 33mentioning

confidence: 99%

“…On the other hand, vasculopathy, due to systemic autoimmune diseases, facilitates the pathogenesis of NMOSD by destructing blood-brain barrier (B.B.B) and with entrance of the AQP4 antibody to CNS [163].…”

Section: Accepted Manuscript 34mentioning

confidence: 99%

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Shahmohammadi

Doosti

Shahmohammadi

et al. 2019

Multiple Sclerosis and Related Disorders

139

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“…We therefore investigated the frequency of IgG anti‐dsDNA and IgG anti‐DWEYS in the serum of patients with NMOSD, an inflammatory and demyelinating disease in which patients have recently been reported to harbor IgG anti‐dsDNA antibodies . The significance and pathogenicity of dsDNA antibodies in the course of NMOSD remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Understanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder

Mader

Jeganathan

Arinuma

et al. 2018

Arthritis & Rheumatology

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Patients with demyelinating NPSLE should be tested for IgG antibodies to AQP-4, MOG, and DWEYS. IgG anti-AQP-4 can be considered diagnostic for NMOSD, whereas none of these antibodies appear to be diagnostic for demyelinating NPSLE. Moreover, IgG anti-dsDNA are present in patients with NMOSD but are not cross-reactive with IgG anti-DWEYS, indicating that the antigenic stimulus and mechanisms of tissue damage are potentially different between demyelinating NPSLE and NMOSD.

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Frequency of autoimmune disorders and autoantibodies in patients with neuromyelitis optica

Cited by 35 publications

References 56 publications

Fri0582 non-Infectious Uveitis as a Manifestation of the Immune Reconstitution Inflammatory Syndromein Patients Infected by Hiv

Fri0582 non-Infectious Uveitis as a Manifestation of the Immune Reconstitution Inflammatory Syndromein Patients Infected by Hiv

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Understanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder

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