Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Shahmohammadi, Sareh; Doosti, Rozita; Shahmohammadi, Abootorab; Mohammadianinejad, Seyed Ehsan; Sahraian, Mohammad Ali; Azimi, Amir Reza; Harirchian, Mohammad Hossein; Asgari, Nasrin; Moghadasi, Abdorreza Naser

doi:10.1016/j.msard.2018.11.008

Cited by 125 publications

(98 citation statements)

References 158 publications

(162 reference statements)

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“…Up to 116 SS reported patients presented with NMOSD. Most of them were females [31]. It has been reported in the pediatric age group as well [41,42].…”

Section: Sjogren's Syndromementioning

confidence: 86%

“…A large percentage of patients (81.82%) had a positive AQP4 antibody test, and 73.7% diagnosed as SLE prior to the NMOSD presentation. However, TM was more frequently reported than ON [31].…”

Section: Neuromyelitis Optica and Its Association With Systemic Autoimentioning

confidence: 95%

“…It has been reported in the pediatric age group as well [41,42]. It was seropositive in 83.72% of 86 patients who were tested for AQP4 antibodies [31]. SS had a severe progressive NMOSD course in comparison to patients without SS [27,43].…”

Section: Sjogren's Syndromementioning

confidence: 99%

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Neuromyelitis optica spectrum standstill in rheumatic systemic autoimmune diseases

Elnady

Fathy

Elkhouly

et al. 2020

Egypt Rheumatol Rehabil

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Background Neuromyelitis optica spectrum disorders (NMOSD) are considered as an autoantibody-mediated disorder that targets aquaporin-4 (AQP4); other autoantibodies could be detected in such spectrum of diseases, including anti-nuclear antibody and antibodies to extractable nuclear antigens. Systemic autoimmune diseases such as systemic lupus erythematosus (SLE), Sjogren’s syndrome (SS), and other autoimmune diseases can overlap with NMOSD. We aimed in this review to address the current evidence describing the relation of NMOSD to systemic autoimmunity diseases, its controversy of being co-association or the same etiology, and its practical implications. Main body The current review was done using a search for related articles or case reports on PubMed until 2019. The keywords included neuromyelitis optica spectrum disorders in combination with autoimmune disease nomenclature. We described the literature background of this controversy, to summarize the evidence of NMOSD relationship to systemic autoimmune diseases. Conclusion NMOSD associated with systemic autoimmune diseases is more common in SLE and Sjogren’s syndrome rather than other autoimmune diseases, frequently affects females more than males; AQP4 antibodies should be tested for all NMOSD like manifestations associated with an autoimmune disorder; however, the clinical diagnosis of NMOSD regardless of the cord lesion length and the presence of positive AQP4 antibody can occur in systemic autoimmune diseases.

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“…Up to 116 SS reported patients presented with NMOSD. Most of them were females [31]. It has been reported in the pediatric age group as well [41,42].…”

Section: Sjogren's Syndromementioning

confidence: 86%

Section: Neuromyelitis Optica and Its Association With Systemic Autoimentioning

confidence: 95%

See 1 more Smart Citation

Neuromyelitis optica spectrum standstill in rheumatic systemic autoimmune diseases

Elnady

Fathy

Elkhouly

et al. 2020

Egypt Rheumatol Rehabil

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“…( Flanagan et al, 2016 ; Kessler et al, 2016 ) Even during non-crisis times when health systems function as usual, NMO requires individualized care due to the high rates of morbidity from NMO attacks and the need for a high degree of immunosuppression with few treatment options available. ( Shahmohammadi et al, 2019 ; Papadopoulos et al, 2014 ; Collongues et al, 2019 )…”

Section: Introductionmentioning

confidence: 99%

Neuromyelitis optica practice and prescribing changes in the setting of Covid19: A survey of neurologists

Rezaei

Vogel

Gazdag

et al. 2020

Journal of Neuroimmunology

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Purpose This study reports and analyzes the findings from the responses of 192 neurologists in the United States and Canada to a new survey instrument distributed in April 2020 to assess NMO practice and prescribing changes during the Covid19 pandemic. Principal results 92% of responding neurologists considered their NMO patients to be at an elevated risk of acquiring Covid19. They also indicated sharp declines in visits, delays in treatment and related services, and several unmet needs deterring treatment. Major conclusions There is a need for evidence-based, comprehensive guidelines for treating NMO patients amid healthcare crises moving forward.

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“…Primary Sjögren's syndrome is the most common overlapping systemic autoimmune disorder with NMOSD. 4 As well, salivary gland biopsies from patients with NMOSD often reveal lymphocytic infiltration, which has been suggested to be due to the similar protein conformation of AQP4 in neuronal foot processes and AQP5 in salivary glands. 5 A similar link is yet to be revealed between MOG-IgG-associated diseases and Sjögren's syndrome.…”

mentioning

confidence: 99%

Recurrent MOG-IgG Optic Neuritis Initially Attributed to Sjögren’s Syndrome

Ling

Micieli

2020

Can. J. Neurol. Sci.

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Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Cited by 125 publications

References 158 publications

Neuromyelitis optica spectrum standstill in rheumatic systemic autoimmune diseases

Neuromyelitis optica spectrum standstill in rheumatic systemic autoimmune diseases

Neuromyelitis optica practice and prescribing changes in the setting of Covid19: A survey of neurologists

Recurrent MOG-IgG Optic Neuritis Initially Attributed to Sjögren’s Syndrome

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