Frequency doubling technology, optical coherence technology and pattern electroretinogram in ocular hypertension

Cellini, Mauro; Toschi, P. G.; Strobbe, Ernesto; Balducci, Nicole; Campos, Emilio C.

doi:10.1186/1471-2415-12-33

Cited by 8 publications

(4 citation statements)

References 37 publications

(44 reference statements)

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“… 24 , 26 This compares with AUCs of 0.78 to 1.00 in the wider literature of visual field tests. 21 – 23 , 27 – 29 Expanding to nonvisual field–based glaucoma screening methods, the AUC for distinguishing glaucoma versus health controls is in the 0.70 to 0.95 range. 14 , 22 , 25 , 30 – 33 …”

Section: Discussionmentioning

confidence: 99%

Comparison of Peristat Online Perimetry with the Humphrey Perimetry in a Clinic-Based Setting

Lowry

Hou

Hennein

et al. 2016

Trans. Vis. Sci. Tech.

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PurposeWe determined the receiver operating characteristic (ROC) curves for Peristat online perimetry at detecting varying degrees of glaucoma and the correlation between Peristat online perimetry and Humphrey visual field.MethodsA prospective, comparative study of Peristat online perimetry (an achromatic static computer threshold testing program) and Humphrey visual field (HVF) 24-2 SITA standard testing was performed by 63 glaucoma patients and 30 healthy controls in random order. The number of total adjacent abnormal test points were identified for each test, and compared with Spearman correlation. Receive operating characteristic curves were generated for Peristat online perimetry detection of mild and moderate-severe glaucoma patients using contrast sensitivity thresholds of −16.7, −21.7, and −26.7 dB.ResultsThe area under the ROC curve for glaucoma detection ranged from 0.77 to 0.81 for mild disease (mean deviation [MD], >−6 dB on HVF) and 0.85 to 0.87 for moderate to severe disease (MD, <−6 dB on HVF) depending on contrast threshold. Peristat online perimetry and Humphrey visual field abnormal points were highly correlated with Spearman rank correlations ranging from 0.55 to 0.77 (all P < 0.001).ConclusionsPeristat online perimetry exhibits a reasonable ROC curve without specialized equipment and exhibited significant correlation with the conventional 24° Humphrey visual field test.Translational RelevanceLow cost widely available internet-based visual fields may complement traditional office-based visual field testing.

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Section: Discussionmentioning

confidence: 99%

Comparison of Peristat Online Perimetry with the Humphrey Perimetry in a Clinic-Based Setting

Lowry

Hou

Hennein

et al. 2016

Trans. Vis. Sci. Tech.

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“…Indeed, in previous studies, FDT-PSD proved to be very sensitive in highlighting early damage of M-Y ganglion cells in diseases that alter the visual pathway (eg, ocular hypertension and early glaucoma). 58 , 59 …”

Section: Discussionmentioning

confidence: 99%

Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia

Schiavi

Tassi

Finzi

et al. 2016

OPTH

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BackgroundSteady-state pattern electroretinogram (PERG) and frequency doubling technology (FDT) perimetry can be used to selectively investigate the activity of the M-Y ganglion cells in adult anisometropic amblyopes.MethodsFifteen normal subjects (mean 27.8±4.1 years) and 15 adults with anisometropic amblyopia (mean 28.7±5.9 years) were analyzed using steady-state PERG and FDT.ResultsThe amplitude of steady-state PERG was significantly different not only among the control group and both the amblyopic eye (P=0.0001) and the sound eye group (P=0.0001), but also between the latter two groups (P=0.006). The difference in FDT mean deviation was statistically significant not only between the control group and amblyopic eye group (P=0.0002), but also between the control group and the sound eye group (P=0.0009). The FDT pattern standard deviation was significantly higher in the control group rather than in the amblyopic eye (P=0.0001) or the sound eye group (P=0.0001). A correlation was found between the reduction in PERG amplitude and the increase in FDT-pattern standard deviation index not only in amblyopic (P=0.0025) and sound (P=0.0023) eyes, but also in the healthy control group (P=0.0001).ConclusionThese data demonstrate that in anisometropic amblyopia, there is an abnormal functionality of a subgroup of the magnocellular ganglion cells (M-Y), and the involvement of these cells, together with the parvocellular pathway, may play a key role in the clinical expression of the disease.

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“…This limited agreement could also be explained by an increased variability as an early sign of glaucomatous damage in these connected sectors. Interesting in this context is a study by Cellini et al [27] They did not include SAP but compared FDT with optical coherence tomography (OCT) and pattern electroretinography (PERG) and found FDT the most sensitive and specific test for detecting early glaucomatous damage in ocular hypertensive subjects. The limited agreement in our study was found in areas where glaucoma tends to start.…”

Section: Discussionmentioning

confidence: 99%

Standard Automated Perimetry versus Matrix Frequency Doubling Technology Perimetry in Subjects with Ocular Hypertension and Healthy Control Subjects

Lamparter¹,

Aliyeva²,

Schulze³

et al. 2013

PLoS ONE

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BackgroundTo evaluate the relationship and agreement between standard automated perimetry (SAP) and Matrix frequency doubling technology (Matrix-FDT) in subjects with ocular hypertension and healthy control subjects.MethodsForty-four eyes of 44 ocular hypertensive subjects and 29 eyes of 29 healthy age-matched control subjects were included in this prospective study. All participants underwent complete ophthalmic examination, including slit-lamp biomicroscopy, intraocular pressure measurement, pachymetry, and dilated fundus examination, and showed reliable visual field tests. One randomly selected eye of each participant was examined with SAP (Swedish Interactive Threshold Algorithm [SITA] Standard 24-2 test) and Matrix-FDT (24-2 threshold test), in random order. Correlations between global indices (MD, PSD), regions (2 hemifields, 4 quadrants, 6 sectors) and 52 single field positions were analyzed using Spearman’s rank correlation coefficient.ResultsIn both groups, mean deviation values of SAP and Matrix-FDT correlated significantly (OHT subjects: r = 0.47, p<0.005; healthy subjects: r = 0.68; p<0.001, respectively). Pattern standard deviation of SAP and Matrix-FDT showed no significant correlation in healthy subjects but correlated significantly in ocular hypertensive subjects (r = 0.45, p<0.005). In healthy subjects, a significant correlation between SAP and Matrix-FDT was shown in the supero-temporal and infero-temporal sectors of the disc (r = 0.40 and r = 0.38, p<0.05, respectively). In OHT subjects, supero-temporal, supero-nasal and nasal sectors correlated significantly (r = 0.49, 0.62 and 0.38, p≤0.01, respectively). The correlation pattern of individual visual field test locations appeared heterogeneous in both groups.ConclusionsIn both, ocular hypertensive and healthy subjects SAP and Matrix-FDT correlate well. In ocular hypertensive subjects, both techniques showed good correlation in the supero-temporal, supero-nasal, and nasal sectors of the disc. Poor agreement was found in the temporal, infero-temporal and infero-nasal disc sectors. This missing correlation might be related to early retinal nerve fiber layer damage in these regions of the disc, recognized by one of the visual field instruments.

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Frequency doubling technology, optical coherence technology and pattern electroretinogram in ocular hypertension

Cited by 8 publications

References 37 publications

Comparison of Peristat Online Perimetry with the Humphrey Perimetry in a Clinic-Based Setting

Comparison of Peristat Online Perimetry with the Humphrey Perimetry in a Clinic-Based Setting

Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia

Standard Automated Perimetry versus Matrix Frequency Doubling Technology Perimetry in Subjects with Ocular Hypertension and Healthy Control Subjects

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