Frequency-Domain Photoacoustic Phase Spectroscopy: A Fluence-Independent Approach for Quantitative Probing of Hemoglobin Oxygen Saturation

Lashkari, Bahman; Choi, Seong-Woo; Dovlo, Edem; Dhody, Saheb; Mandelis, Andreas

doi:10.1109/jstqe.2015.2494532

Cited by 14 publications

(14 citation statements)

References 45 publications

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“…54 Unlike pulse-based IV-PA that provides a single amplitude channel, CW-based IV-PA provides an additional correlation phase channel that is independent of the optical fluence. 54,86 This phase channel is usually represented in the form of its inverse standard deviation (ISDV) which correlates with the probability of the presence of PA sources at certain depths. 54 Then, such statistical information is encoded on the amplitude channel into phasefiltered amplitude (PFA) channel by simple multiplication.…”

Section: Generation Of Conventional Cw-based Pa Signalsmentioning

confidence: 99%

Review of the state of the art in cardiovascular endoscopy imaging of atherosclerosis using photoacoustic techniques with pulsed and continuous-wave optical excitations

Choi

Mandelis

2019

J. Biomed. Opt.

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Review of the state of the art in cardiovascular endoscopy imaging of atherosclerosis using photoacoustic techniques with pulsed and continuous-wave optical excitations," J.Abstract. Intravascular photoacoustics (IV-PA) is an emerging atherosclerosis imaging modality that provides chemical-specific optical information of arterial walls with acoustic depth penetration and resolution. As lipid composition of atherosclerotic plaques is considered to be one of the primary indicators for plaque vulnerability, many IV-PA applications are calibrated so as to target plaque necrotic cores. Based on the mode of optical excitation and the corresponding signal processing technique, IV-PA is categorized into two different modalities. The pulse-based IV-PA has been the universal IV-PA imaging mode with its high peak power and straightforward time-domain signal processing technique. As an alternative, the low power continuous-wave (CW)-based IV-PA has been under intense development as a radar-like frequency-domain signal processing modality. The two state-of-the-art types of IV-PA are reviewed in terms of their physics and imaging capabilities, with major emphasis on frequency-swept CW-based IV-PA that has been recently introduced in the field. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Generation Of Conventional Cw-based Pa Signalsmentioning

confidence: 99%

Review of the state of the art in cardiovascular endoscopy imaging of atherosclerosis using photoacoustic techniques with pulsed and continuous-wave optical excitations

Choi

Mandelis

2019

J. Biomed. Opt.

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“…The laser fluence is assumed to be known in the tissue when uses two wavelengths to measure the hemoglobin oxygen saturation. In reality, the fluence is unknown because the optical scatter is not wavelength-independent, so this assumption will cause some error [ 92 ]. Bahman Lashkari et al proposed a method which employs the phase of the FD photoacoustic signals to measure the absorption coefficient and quantitatively probe the hemoglobin oxygen saturation without the influence of fluence [ 92 ].…”

Section: Continuous Modulationmentioning

confidence: 99%

Review of Low-Cost Photoacoustic Sensing and Imaging Based on Laser Diode and Light-Emitting Diode

Zhong

Duan

Lan

et al. 2018

Sensors

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Photoacoustic tomography (PAT), a promising medical imaging method that combines optical and ultrasound techniques, has been developing for decades mostly in preclinical application. A recent trend is to utilize the economical laser source to develop a low-cost sensing and imaging system, which aims at an affordable solution in clinical application. These low-cost laser sources have different modulation modes such as pulsed modulation, continuous modulation and coded modulation to generate different profiles of PA signals in photoacoustic (PA) imaging. In this paper, we review the recent development of the photoacoustic sensing and imaging based on the economical laser sources such as laser diode (LD) and light-emitting diode (LED) in different kinds of modulation types, and discuss several representative methods to improve the performance of such imaging systems based on low-cost laser sources. Finally, some perspectives regarding the future development of portable PAT systems are discussed, followed by the conclusion.

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“…This section provides the theoretical background of four different frequency-domain PA methodologies that can be used for absolute SO 2 characterization and imaging. While the detailed derivation of the Fourier-Domain PA signal generation was covered elsewhere [14,15], a simple proportionality of the PA amplitude can be described as:…”

Section: Theoretical Backgroundmentioning

confidence: 99%

“…This methodology where two single-ended PA phase signals are used to estimate SO 2 was studied theoretically and experimentally elsewhere [15]. The idea was that the Hb absorption coefficient difference between two wavelengths is proportional to the difference in the two single-ended PA phase signals at the corresponding wavelengths as shown in Eq.…”

Section: Two-wavelength Single-ended Phase Imagingmentioning

confidence: 99%

Wavelength-modulated differential photoacoustic radar imager (WM-DPARI): accurate monitoring of absolute hemoglobin oxygen saturation

Choi

Lashkari

Dovlo

et al. 2016

Biomed. Opt. Express

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Accurate monitoring of blood oxy-saturation level (SO2 ) in human breast tissues is clinically important for predicting and evaluating possible tumor growth at the site. In this work, four different non-invasive frequency-domain photoacoustic (PA) imaging modalities were compared for their absolute SO2 characterization capability using an in-vitro sheep blood circulation system. Among different PA modes, a new WM-DPAR imaging modality could estimate the SO2 with great accuracy when compared to a commercial blood gas analyzer. The developed WM-DPARI theory was further validated by constructing SO2 tomographic images of a blood-containing plastisol phantom.

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Frequency-Domain Photoacoustic Phase Spectroscopy: A Fluence-Independent Approach for Quantitative Probing of Hemoglobin Oxygen Saturation

Cited by 14 publications

References 45 publications

Review of the state of the art in cardiovascular endoscopy imaging of atherosclerosis using photoacoustic techniques with pulsed and continuous-wave optical excitations

Review of the state of the art in cardiovascular endoscopy imaging of atherosclerosis using photoacoustic techniques with pulsed and continuous-wave optical excitations

Review of Low-Cost Photoacoustic Sensing and Imaging Based on Laser Diode and Light-Emitting Diode

Wavelength-modulated differential photoacoustic radar imager (WM-DPARI): accurate monitoring of absolute hemoglobin oxygen saturation

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