Wavelength-modulated differential photoacoustic radar imager (WM-DPARI): accurate monitoring of absolute hemoglobin oxygen saturation

Choi, Seong-Woo; Lashkari, Bahman; Dovlo, Edem; Mandelis, Andreas

doi:10.1364/boe.7.002586

Cited by 13 publications

(12 citation statements)

References 16 publications

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“…High-resolution optoacoustic images of tissue phantoms were reconstructed by our group in early 2000s; since then biomedical optoacoustics/photoacoustics has grown tremendously. Recent original papers and reviews by other groups (and references therein) demonstrate remarkable progress in optoacoustic imaging, cancer detection, microscopy, functional imaging in small animals, optoacoustic instrumentation, dual modality optoacoustic/ultrasound imaging, contrast agents development, and other applications (Jaeger et al, 2013 ; O'Donnell et al, 2013 ; Su et al, 2013 ; Daoudi et al, 2014 ; Ellwood et al, 2014 ; Yao and Wang, 2014 ; Taruttis et al, 2015 ; Bourantas et al, 2016 ; Cai et al, 2016 ; Choi et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Optoacoustic Monitoring of Physiologic Variables

Esenaliev

2017

Front. Physiol.

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Optoacoustic (photoacoustic) technique is a novel diagnostic platform that can be used for noninvasive measurements of physiologic variables, functional imaging, and hemodynamic monitoring. This technique is based on generation and time-resolved detection of optoacoustic (thermoelastic) waves generated in tissue by short optical pulses. This provides probing of tissues and individual blood vessels with high optical contrast and ultrasound spatial resolution. Because the optoacoustic waves carry information on tissue optical and thermophysical properties, detection, and analysis of the optoacoustic waves allow for measurements of physiologic variables with high accuracy and specificity. We proposed to use the optoacoustic technique for monitoring of a number of important physiologic variables including temperature, thermal coagulation, freezing, concentration of molecular dyes, nanoparticles, oxygenation, and hemoglobin concentration. In this review we present origin of contrast and high spatial resolution in these measurements performed with optoacoustic systems developed and built by our group. We summarize data obtained in vitro, in experimental animals, and in humans on monitoring of these physiologic variables. Our data indicate that the optoacoustic technology may be used for monitoring of cerebral blood oxygenation in patients with traumatic brain injury and in neonatal patients, central venous oxygenation monitoring, total hemoglobin concentration monitoring, hematoma detection and characterization, monitoring of temperature, and coagulation and freezing boundaries during thermotherapy.

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Section: Discussionmentioning

confidence: 99%

Optoacoustic Monitoring of Physiologic Variables

Esenaliev

2017

Front. Physiol.

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“…We employ frequency-domain (or Fourier-domain, FD) PA to evaluate the absorption coefficient and the Grüneisen parameter of lipids. The methodology and various techniques of FD-PA for spectroscopic probing and imaging have been discussed before, where the main subject was the evaluation of the blood oxygenation level [ [33] , [34] , [35] , [36] , [37] ]. Furthermore, we report the Grüneisen parameter of some lipids such as mineral oil, castor oil, olive oil, glycerin as well as cholesterol and cholesteryl oleate.…”

Section: Introductionmentioning

confidence: 99%

The application of frequency-domain photoacoustics to temperature-dependent measurements of the Grüneisen parameter in lipids

et al. 2018

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The Grüneisen parameter is an essential factor in biomedical photoacoustic (PA) diagnostics. In most PA imaging applications, the variation of the Grüneisen parameter with tissue type is insignificant. This is not the case for PA imaging and characterization of lipids, as they have a very distinct Grüneisen parameter compared with other tissue types. One example of PA applications involving lipids is the imaging and characterization of atherosclerotic plaques. Intravascular photoacoustic (IVPA) imaging is a promising diagnostic tool that can evaluate both plaque severity and composition. The literature for IVPA has mainly focused on using the difference in absorption coefficients between plaque components and healthy arterial tissues. However, the Grüneisen parameters for lipids and their behavior with temperature have not been well established in the literature. In this study we employ frequency-domain photoacoustic measurements to estimate the Grüneisen parameter by virtue of the ability of this modality to independently measure both the absorption coefficient and the Grüneisen parameter through the use of the phase channel. The values of the Grüneisen parameters of some lipids are calculated as functions of temperature in the range 25–45 °C.

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“…Detailed descriptions of the foundations of our WM‐DPAR (and FD‐PAR) technique are available elsewhere . The superior accuracy of the WM‐DPAR method in SO 2 quantification of an in‐vitro blood‐containing plastisol phantom over other PA modalities has also been shown in and verified using a gas analyzer (gold standard). The sample (rat thigh) is positioned near the center of rotation, 25 mm from the surface of the transducer, and 100 chirps are coherently averaged to enhance the SNR of the PA signals.…”

Section: Methodsmentioning

confidence: 99%

Quantitative phase‐filtered wavelength‐modulated differential photoacoustic radar tumor hypoxia imaging toward early cancer detection

Dovlo

Lashkari

Choi

et al. 2016

Journal of Biophotonics

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Overcoming the limitations of conventional linear spectroscopy used in multispectral photoacoustic imaging, wherein a linear relationship is assumed between the absorbed optical energy and the absorption spectra of the chromophore at a specific location, is crucial for obtaining accurate spatially-resolved quantitative functional information by exploiting known chromophore-specific spectral characteristics. This study introduces a non-invasive phase-filtered differential photoacoustic technique, wavelength-modulated differential photoacoustic radar (WM-DPAR) imaging that addresses this issue by eliminating the effect of the unknown wavelength-dependent fluence. It employs two laser wavelengths modulated out-of-phase to significantly suppress background absorption while amplifying the difference between the two photoacoustic signals. This facilitates pre-malignant tumor identification and hypoxia monitoring, as minute changes in total hemoglobin concentration and hemoglobin oxygenation are detectable. The system can be tuned for specific applications such as cancer screening and SO quantification by regulating the amplitude ratio and phase shift of the signal. The WM-DPAR imaging of a head and neck carcinoma tumor grown in the thigh of a nude rat demonstrates the functional PA imaging of small animals in vivo. The PA appearance of the tumor in relation to tumor vascularity is investigated by immunohistochemistry. Phase-filtered WM-DPAR imaging is also illustrated, maximizing quantitative SO imaging fidelity of tissues. Oxygenation levels within a tumor grown in the thigh of a nude rat using the two-wavelength phase-filtered differential PAR method.

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Wavelength-modulated differential photoacoustic radar imager (WM-DPARI): accurate monitoring of absolute hemoglobin oxygen saturation

Cited by 13 publications

References 16 publications

Optoacoustic Monitoring of Physiologic Variables

Optoacoustic Monitoring of Physiologic Variables

The application of frequency-domain photoacoustics to temperature-dependent measurements of the Grüneisen parameter in lipids

Quantitative phase‐filtered wavelength‐modulated differential photoacoustic radar tumor hypoxia imaging toward early cancer detection

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