Frequency, distribution, and immunomorphologic characteristics of peripheral T-cell lymphoma, not otherwise specified in a tertiary care center in Southern India

Lakshmanan, Archana; Sikri, Deeksha; Patil, Saurabh; Kurian, Achamma; Annapurneswari, S; Nair, Shalini

doi:10.4103/ijpm.ijpm_405_17

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…The main subtype obtained from the reclassification with the newer IHC panel was TFH-derived lymphomas, which is similar to previous studies 9. AITL occurred in 9.25% of the T-cell lymphomas, similar to a previous Indian study, but varied prevalence has been noted 7,12,13. At our tertiary care center, mild skewing was expected in view of high referral rate.…”

Section: Discussionsupporting

confidence: 88%

“…9 AITL occurred in 9.25% of the T-cell lymphomas, similar to a previous Indian study, but varied prevalence has been noted. 7,12,13 At our tertiary care center, mild skewing was expected in view of high referral rate. Males formed the bulk of the study cohort with a slightly younger median age than in Western populations, which could be attributed to a younger Indian age pyramid, and a lower male-to-female ratio was noted in AITL patients.…”

Section: Discussionmentioning

confidence: 98%

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Follicular Helper T-Cell–derived Nodal Lymphomas: Study of Histomorphologic, Immunophenotypic, Clinical, and RHOA G17V Mutational Profile

Jain¹,

Goswami²,

Lone³

et al. 2023

Applied Immunohistochemistry &Amp; Molecular Morphology

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The study was designed to review the demographic, clinical, and pathologic characteristics of follicular helper T cells (TFH)-derived nodal PTCL in India including angioimmunoblastic T-cell lymphoma (AITL), peripheral T-cell lymphoma (PTCL) with follicular helper T cell phenotype (P-TFH), and follicular T-cell lymphoma with additional immunohistochemistry (IHC) and RHOAG17V mutational analysis, as well as their impact on survival. This retrospective study included 88 cases of PTCL that were reclassified using IHC for TFH markers (PD1, ICOS, BCL6, and CD10) and dendritic-meshwork markers (CD21, CD23). Cases of TFH cell origin were evaluated for RHOAG17V mutation using Sanger sequencing and amplification-refractory mutation system-polymerase chain reaction (PCR) (validated using cloning and quantitative PCR) with detailed clinicopathologic correlation. Extensive re-evaluation with added IHC panel resulted in a total of 19 cases being reclassified, and the final subtypes were AITL (37 cases, 42%), PTCL-not otherwise specified (44, 50%), P-TFH (6, 7%), and follicular T-cell lymphoma (1, 1%). The presence of at least 2 TFH markers ( > 20% immunopositivity) determined the TFH origin. AITL patients tended to be male and showed increased presence of B-symptoms and hepatosplenomegaly. Histomorphology revealed that 92% of AITL cases had pattern 3 involvement. Sanger sequencing with conventional PCR did not yield any mutation, while RHOAG17V was detected by amplification-refractory mutation system-PCR in AITL (51%, P = 0.027) and P-TFH (17%), which was validated with cloning followed by sequencing. Cases of RHOAG17V-mutant AITL had a worse Eastern Cooperative Oncology Group performance status initially but fared better in terms of overall outcome (P = 0.029). Although not specific for AITL, RHOAG17V mutation shows an association with diagnosis and requires sensitive methods for detection due to low-tumor burden. The mutant status of AITL could have prognostic implications and translational relevance.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Follicular Helper T-Cell–derived Nodal Lymphomas: Study of Histomorphologic, Immunophenotypic, Clinical, and RHOA G17V Mutational Profile

Jain¹,

Goswami²,

Lone³

et al. 2023

Applied Immunohistochemistry &Amp; Molecular Morphology

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“…PTCL accounts for less than 15% of all NHLs in the United States and Europe but they are more frequent in the Far East [4,5]. PTCL not otherwise specified (NOS) is the most common group of PTCL and it includes cases that do not correspond to any specific subtype [5,6]. Despite aggressive chemotherapy, the majority of patients with most subtypes of PTCL have unfavorable prognosis [7].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with PTCL present predominantly with nodal disease, but extranodal disease is often present, with skin being the most common extranodal site [10]. Pulmonary involvement is relatively rare; its frequency has been assessed from 2% to 8% of the cases, while extrapulmonary manifestations in the form of pleural effusions are present in 3%–12% of the individuals with this disorder [6,10]. The chest imaging findings of PTCL have not been well characterized [11].…”

Section: Discussionmentioning

confidence: 99%

Crazy paving pattern as a rare radiological manifestation of peripheral T-cell lymphoma (PTCL) with lung involvement: A case report

Gomatou

Tzilas

Kourti

et al. 2018

Respiratory Medicine Case Reports

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We report on a 70-year old woman with dyspnea, systemic lymphadenopathy and abnormal chest computed tomography (CT) findings. A complete laboratory testing as well as mediastinal tissue sampling via Endobronchial Ultrasound (EBUS)-guided Transbronchial Needle Biopsy (TBNB) did not reveal a definite diagnosis. After experiencing acute respiratory failure which led to intensive care unit, the patient underwent a cervical lymph node biopsy which revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS). A CT-guided trans-thoracic lung biopsy was performed that showed involvement of the lung parenchyma in the context of PTCL-NOS. Lung involvement is a rare extra-nodal manifestation of PTCL. The imaging patterns of this lymphoma have not been well described. We conclude that the finding of crazy paving pattern is a rare manifestation of this disease. In patients with pre-existing lymphoma, lung involvement should be included in the differential due to high pre-test probability.

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T-cell lymphoproliferative processes in the spleen

Aguilera

Auerbach²

2020

Seminars in Diagnostic Pathology

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Frequency, distribution, and immunomorphologic characteristics of peripheral T-cell lymphoma, not otherwise specified in a tertiary care center in Southern India

Cited by 5 publications

References 29 publications

Follicular Helper T-Cell–derived Nodal Lymphomas: Study of Histomorphologic, Immunophenotypic, Clinical, and RHOA G17V Mutational Profile

Follicular Helper T-Cell–derived Nodal Lymphomas: Study of Histomorphologic, Immunophenotypic, Clinical, and RHOA G17V Mutational Profile

Crazy paving pattern as a rare radiological manifestation of peripheral T-cell lymphoma (PTCL) with lung involvement: A case report

T-cell lymphoproliferative processes in the spleen

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