Frequency-dependent effects of sequenced pulsed magnetic field on experimental diabetic neuropathy

Mert, Tufan; Gişi, Gökçe; Çelik, Ahmet; Baran, Furkan; Uremis, Muhammed Mehdi; Günay, İsmail

doi:10.3109/09553002.2015.1068460

Cited by 8 publications

(8 citation statements)

References 39 publications

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“…In the literature, 40 Hz magnetic field was used for wound healing, bone marrow edema and diabetic neuropathy for treatment purposes, and positive results have been reported. 2 , 3 , 4 In another study, the rats were exposed to pulsed magnetic field of 50 Hz for 3 times a day for 4 h and it was found to reduce necrosis in urethral cells. 22 For almost 50 years various forms of EMFs have been used to promote bone formation after fractures as well as for the treatment of osteoporosis.…”

Section: Discussionmentioning

confidence: 97%

“…Exteremely Low and Low frequency pulsed magnetic field is recently and frequently been used in many treatments like neuropathy therapy, bone marrow edema, promoting bone formation after fractures and wound healing in different departments. 2 , 3 , 4 , 5 High Frequency electromagnetic waves are the radio waves which are used in mobile communications. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

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The effect of very low dose pulsed magnetic waves on cochlea

Tuhanioğlu

Erkan

Gürgen

et al. 2019

Brazilian Journal of Otorhinolaryngology

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The effect of very low dose pulsed magnetic waves on cochlea

Tuhanioğlu

Erkan

Gürgen

et al. 2019

Brazilian Journal of Otorhinolaryngology

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“…These might due to the different frequency range, wavelength and energy between RF and ELF MF. The mechanism of how magnetic fields affect biological processes remains unclear, but it is widely accepted different frequencies interact with the body in different ways (Mert et al, ). The bioeffects of ELF MF have been observed within relatively narrow frequency windows (Prato et al, ), which indicated that the sensitivity of LECs to electromagnetic field appear to be limited to an optimal frequency.…”

Section: Discussionmentioning

confidence: 99%

Extremely Low Frequency Magnetic Fields Do Not Induce DNA Damage in Human Lens Epithelial Cells In Vitro

Zhu

Qian³

et al. 2016

The Anatomical Record

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Non-ionizing radiations, e.g., radiofrequency electromagnetic fields, could induce DNA damage and oxidative stress in human lens epithelial cells (LECs) which can be early events in cataractogenesis. Extremely low frequency magnetic fields (ELF MF) as another common form of manmade electromagnetic fields has been considered as suspected human carcinogen by International Agency for Research on Cancer (IARC) and become a focus that people play more and more attentions to. This study aimed to determine whether ELF MF can induce DNA damage in cultured human LECs at a relatively low intensity. Human LECs were exposed or sham-exposed to a 50 Hz ELF MF which produced by a well-designed exposure system at the intensity of 0.4 mT. DNA damage in human LECs was examined by the phosphorylated form of histone variant H2AX (gH2AX) foci formation assay and further explored with western blot, flow cytometry, and alkaline comet assay. Immunofluorescence analysis showed that 0.4 mT ELF MF did not significantly increase gH2AX foci formation in human LECs after 2, 6, 12, 24, or 48 hr exposure. No significant differences had been detected in gH2AX expression level between the ELF MFand sham-exposure groups, while no obvious chromosomal DNA fragmentation was detected by alkaline comet assay after ELF MF exposure. The results indicate an absence of genotoxicity in ELF MF-exposed human epithelial cells and do not support the hypothesis that environmental ELF MF might be causally led to genomic instability via chromosomal damage response processes. Neither short nor long term continuous exposure to 50 Hz ELF MF at 0.4 mT could induce DNA damage in human lens epithelial cells in vitro. Anat Rec, 299:688-697,

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“…Using a STZ-rat model, the effects of PEMFT on allodynia and hyperalgesia were evaluated using PEMF spiked pulse trains of different frequencies with peak field intensities of 1.5 mT [ 28 ]. The treatment pattern used repeating four-minute bursts of impulses alternating between either 1-Hz and 5-Hz or between 30-Hz and 40-Hz for an overall treatment interval of 60 minutes.…”

Section: Reviewmentioning

confidence: 99%

Do Magnetic Fields Have a Place in Treating Vascular Complications in Diabetes?

Mayrovitz¹,

Maqsood²,

Tawakalzada³

2022

Cureus

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The use of electromagnetic field therapy (EMFT) is a non-invasive, potential alternative or complementary choice in the treatment of wounds, chronic pain, neuropathy, and other medical conditions, including tissue repair and cell proliferation. Static magnetic fields (SMFs) have been reported to increase microcirculatory blood flow by mediating vasodilation via nitric oxide. Studies report that SMF exposure causes homeostatic, normalizing effects on the vascular tone that may have beneficial effects in situations where tissue perfusion is limited, such as may be present in diabetes. Pulsed electromagnetic fields (PEMFs) have also shown promise in treating diabetic wounds by improving wound healing rates and other attributes. Our purpose was to critically review prior applications of EMFT for relevancy and effectiveness in treating diabetic complications. The goal was to provide information to allow for informed decisions on the possible use of these modalities in the treatment of persons with diabetic complications. The focus was on the following major areas: wound healing, neuropathy, blood glucose control, blood flow, inflammation and oxidative stress.

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Frequency-dependent effects of sequenced pulsed magnetic field on experimental diabetic neuropathy

Cited by 8 publications

References 39 publications

The effect of very low dose pulsed magnetic waves on cochlea

The effect of very low dose pulsed magnetic waves on cochlea

Extremely Low Frequency Magnetic Fields Do Not Induce DNA Damage in Human Lens Epithelial Cells In Vitro

Do Magnetic Fields Have a Place in Treating Vascular Complications in Diabetes?

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