Frequency, correlates, and clinical implications of myocardial perfusion after primary angioplasty and stenting, with and without glycoprotein IIb/IIIa inhibition, in acute myocardial infarction

Costantini, Costantino O.; Stone, Gregg W.; Mehran, Roxana; Aymong, Eve; Grines, Cindy L.; Cox, David A.; Stuckey, Thomas; Turco, Mark; Gersh, Bernard J.; Tcheng, James E.; Garcı́a, Eulogio; Griffin, John J.; Guagliumi, Giulio; Leon, Martin B.; Lansky, Alexandra J.

doi:10.1016/j.jacc.2004.03.058

Cited by 170 publications

(91 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TMPG-3 on coronary angiogram is generally achieved only in less than 30% of the patients with AMI after primary PCI (Gibson et al,2000) (Costantini et al,2004), while good reflow is observed on 2D-MCE in about 70% of the patients (Ito et al,1992) (Galiuto et al,1998) (Porter et al,1998). TMPG grade was far better correlated with MOE on 3D-MCE than with perfusion pattern on 2D-MCE in the present study.…”

Section: Comparison Between 2d-and 3d-mce For Detection Of the No-reflowsupporting

confidence: 44%

3D Myocardial Contrast Echocardiography

Iwakura¹

2012

Echocardiography - New Techniques

View full text Add to dashboard Cite

Section: Comparison Between 2d-and 3d-mce For Detection Of the No-reflowsupporting

confidence: 44%

3D Myocardial Contrast Echocardiography

Iwakura¹

2012

Echocardiography - New Techniques

View full text Add to dashboard Cite

“…However, epicardial recanalization does not guarantee optimal myocardial perfusion, which remains suboptimal in a relatively large proportion of patients [8,9]. In addition, concomitant atherosclerosis in coronary vessels other than the infarct-related artery (IRA) is observed in a notable proportion of patients undergoing primary percutaneous coronary intervention (PCI), ranging from 40% to 50% [10e12].…”

Section: Introductionmentioning

confidence: 99%

Impact of multivessel disease on infarct size among STEMI patients undergoing primary angioplasty

Luca¹,

Parodi²,

Sciagrà³

et al. 2014

Atherosclerosis

View full text Add to dashboard Cite

a b s t r a c tBackground: Although primary angioplasty achieves Thrombolysis In Myocardial Infarction (TIMI) 3 flow in most patients with ST-elevation myocardial infarction, epicardial recanalization does not guarantee optimal perfusion in a large proportion of patients. Multivessel disease has been demonstrated to be associated with impaired survival, however its impact on infarct size has not been largely investigated, that therefore is the aim of the current study.

show abstract

“…However, even though primary angioplasty has been shown to provide larger benefits as compared with thrombolysis, a suboptimal myocardial reperfusion is observed in a still relevant proportion of patients, despite optimal epicardial recanalization [7][8][9]. Hypertension is an established risk factor for atherosclerosis [10].…”

Section: Introductionmentioning

confidence: 99%

Impact of hypertension on infarct size in ST elevation myocardial infarction patients undergoing primary angioplasty

Luca

Parodi

Sciagrà

et al. 2013

Journal of Hypertension

View full text Add to dashboard Cite

Background: Hypertension is a well known risk factor for atherosclerosis. However, data on the impact of hypertension in patients with ST-segment elevation myocardial infarction (STEMI) are inconsistent, and mainly related to studies performed in the thrombolytic era, with very few data on patients undergoing primary angioplasty. The aim of the current study was to evaluate the impact of hypertension on scintigraphic infarct size in STEMI patients undergoing primary percutaneous coronary intervention (PCI). Method: Our population is represented by 830 STEMI patients undergoing primary PCI. Infarct size was evaluated at 30 days by technetium-99m-sestamibi. Results: Hypertension was associated with more advanced age (P < 0.001), a larger prevalence of diabetes (P ¼ 0.001), female sex (P < 0.001), but lower prevalence of smoking (P < 0.001) and anterior infarction (P ¼ 0.042). No difference was observed in ischemia time, cardiogenic shock at presentation, in preprocedural thrombolysis in myocardial infarction (TIMI) flow, and collateral circulation. Hypertension did not affect the rate of postprocedural TIMI 3 flow. Hypertension did not affect infarct size [12.5% (4.1-23.8%) vs. 12.8% (4.3-24.7%), P ¼ 0.38]. Similar results were observed in subanalyses in major high-risk subgroups. No impact of hypertension on infarct size was confirmed when the analysis was conducted according to the percentage of patients with infarct size above the median [adjusted odds ratio (95% CI) ¼ 0.97 (0.72-1.33),Conclusion: This study shows that among STEMI patients, undergoing primary PCI hypertension does not affect scintigraphic infarct size.

show abstract

Frequency, correlates, and clinical implications of myocardial perfusion after primary angioplasty and stenting, with and without glycoprotein IIb/IIIa inhibition, in acute myocardial infarction

Cited by 170 publications

References 30 publications

3D Myocardial Contrast Echocardiography

3D Myocardial Contrast Echocardiography

Impact of multivessel disease on infarct size among STEMI patients undergoing primary angioplasty

Impact of hypertension on infarct size in ST elevation myocardial infarction patients undergoing primary angioplasty

Contact Info

Product

Resources

About