Frequency and Risk Factors for Extraintestinal Manifestations in the Swiss Inflammatory Bowel Disease Cohort

Abstract

EIMs are a frequent problem in CD and UC patients. Active disease and positive IBD family history are associated with ongoing EIM in CD patients. Identification of EIM prevalence and associated risk factors may result in increased awareness for this problem and thereby facilitating their diagnosis and therapeutic management.

25 Incidence of Spondyloarthropathy in Patients With Ulcerative Colitis: A Population-Based Study

“…Similar to our study, psoriasis and uveitis were diagnosed by a dermatologist or ophthalmologist, respectively. Finally, unlike our study, the Swiss study was not a population-based cohort (23).…”

“…The frequencies of uveitis and arthritis in our UC cohort were lower when compared to that of the Swiss Inflammatory Bowel Disease Cohort study, which examined all extraintestinal manifestations of inflammatory bowel disease patients based on questionnaires completed by treating physicians (23). Uveitis and arthritis were found in 3.8% and 21.3%, respectively, of UC patients in the Swiss study, while we found those frequencies were 3.4% (oligoarthritis), 0.5% (polyarthritis), and 2.8% (uveitis) after UC diagnosis (24).…”

Extraintestinal Manifestations of Inflammatory Bowel Diseases

“…The reported frequencies of EIMs in patients with IBD have varied between 6% and 47% (15)(16)(17)(18)(19)(20). Globally, about one-third of patients develop systemic manifestations (10).…”

Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previously Reported

“…Though there is an extensive literature describing the association of complications with IBD, demonstrating for example that VTE is 3-4 times more common in patients with IBD than in the general population [1,2], the number of controlled studies of extra intestinal manifestations available are remarkably few [3,4]. Most of the literature constitutes case series or cohort studies of IBD patients describing the frequency of these manifestations, which does not allow us to examine variations in the frequency of these problems between patients with and without IBD [5,6]. It is believed from these studies that extra-intestinal manifestations affect about 40% of IBD patients [5,7].…”

“…Most of the literature constitutes case series or cohort studies of IBD patients describing the frequency of these manifestations, which does not allow us to examine variations in the frequency of these problems between patients with and without IBD [5,6]. It is believed from these studies that extra-intestinal manifestations affect about 40% of IBD patients [5,7]. To our knowledge only one other recent high quality epidemiological study has compared extra-intestinal manifestations (EIMs) in IBD to general population controls, but that study did not report on peripheral arthritis which is the most commonly reported EIM in many series [8].…”