Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previously Reported

Card, Timothy R.; Langan, Sinéad; Chu, Thomas P. C.

doi:10.1007/s10620-016-4195-1

Cited by 48 publications

(52 citation statements)

References 20 publications

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“…Our patient's history of seronegative arthritis may be associated with her skin disease. Affected patients exemplify a triad of IBD, PG, and seronegative arthritis concurrently [7]. PG has rarely been documented to occur with seronegative arthritis but without IBD -however, our patient is one such case [6].…”

Section: Discussionmentioning

confidence: 69%

Pyoderma Gangrenosum of the Face: A Rare Presentation and a Rapid Resolution

Shah¹,

Gottwald²,

Sheskey³

et al. 2018

TODJ

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Background:Pyoderma Gangrenosum (PG) is a disorder of neutrophil chemotaxis that often affects the lower extremities of patients with concurrent autoimmune disorders. Result and Discussion:Resolution of lesions typically requires a minimum of six weeks of treatment with systemic steroids. We present a unique case of multifocal PG involving the hand and face that healed after ten days of treatment with oral prednisone.

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Section: Discussionmentioning

confidence: 69%

Pyoderma Gangrenosum of the Face: A Rare Presentation and a Rapid Resolution

Shah¹,

Gottwald²,

Sheskey³

et al. 2018

TODJ

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“…Some researchers have suggested that the systemic inflammatory response may modulate the host microbiome of IBD, and has received increased attention [23,24]. Lots of studies have indicated that effective and efficient therapy could significantly control clinical symptoms (extraintestinal manifestations), reduce relapse, maintain remission, and improve the quality of life [25][26][27]. Therefore, selecting an ideal non-invasive test is increasingly expected and needed.…”

Section: Discussionmentioning

confidence: 99%

Systemic inflammation response index (SIRI) as a predictor for predicting inflammatory bowel disease (IBD) severity

Yu¹,

Yu²,

Ou³

et al. 2018

biomedicalresearch

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Peripheral venous blood markers may reflect the systematic inflammatory response condition. Various indices have been used to evaluate Inflammatory Bowel Disease (IBD), however, there is no ideal maker to assess the IBD activity and severity. We aim to investigate the potential value of Systemic Inflammation Response Index (SIRI) in IBD patients, and use it to predict the disease activity and severity. We designed a retrospective study to evaluate the SIRI in estimating disease severity in patients with IBD. We enrolled 210 patients with IBD, included 110 cases of Ulcerative Colitis (UC) and 100 cases of Crohn's Disease (

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“…However, the lack of patients with this complication in our study made it impossible to conclude any relationship with the LY75 SNPs. As the prevalence of erythema nodosum as an extra-intestinal symptom of CD is 2.3% [32], larger studies are needed to conclude if LY75 SNPs are related to this complication in Japanese CD patients.…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Antigen 75 Polymorphisms Are Associated with Disease Susceptibility and Phenotype in Japanese Patients with Inflammatory Bowel Disease

et al. 2016

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Recent genome-wide association studies have rapidly improved our understanding of the molecular pathways leading to inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC). Although several reports have demonstrated that gene single nucleotide polymorphisms (SNPs) are associated with susceptibility to IBD, its precise genetic factors have not been fully clarified. Here, we performed an association analysis between lymphocyte antigen 75 (LY75) genetic variations and IBD susceptibility or phenotype. SNPs were genotyped in 51 CD patients, 94 UC patients, and 269 healthy controls of Japanese ethnicity. We detected a significant relationship with CD susceptibility for the rs16822581 LY75 SNP (P = 0.045). One haplotype (GT, P = 0.042) was also associated with CD susceptibility, while another carrying the opposite SNP (CA) was linked to an absence of surgical history for CD. Our findings confirm that LY75 is involved in CD susceptibility and may play a role in disease activity in the Japanese population.

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Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previously Reported

Abstract: . (2016) Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported. Digestive Diseases and Sciences, 61 (9).

Cited by 48 publications

References 20 publications

Pyoderma Gangrenosum of the Face: A Rare Presentation and a Rapid Resolution

Pyoderma Gangrenosum of the Face: A Rare Presentation and a Rapid Resolution

Systemic inflammation response index (SIRI) as a predictor for predicting inflammatory bowel disease (IBD) severity

Lymphocyte Antigen 75 Polymorphisms Are Associated with Disease Susceptibility and Phenotype in Japanese Patients with Inflammatory Bowel Disease

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