Systemic inflammation response index (SIRI) as a predictor for predicting inflammatory bowel disease (IBD) severity

Yu, Ting; Yu, Qian; Ou, Xilong; Cao, D F

doi:10.4066/biomedicalresearch.29-17-3202

Cited by 2 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our research revealed statistically significant differences higher SIRI values in the S UC group compared to the Mi group, and higher SII values in the E3 group compared to the E1 group. The SIRI was formulated by YU et al [29], using the peripheral venous blood neutrophil, monocyte, and lymphocyte counts. The authors indicated that higher SIRI levels were significantly correlated with active inflammatory bowel disease (IBD), CRP, ESR, NLR, and MLR, and might be a novel promising marker of the disease severity in IBD.…”

Section: The Inflammatory Status Biomarkersmentioning

confidence: 99%

“…Noteworthy are the following hematological markers of systemic inflammation derived from the complete blood count panel (CBC): neutrophil-to-lymphocyte ratio (NLR), which highlights leukocytosis and lymphopenia in its initial inflammatory stage; monocyteto-lymphocyte ratio (MLR), which contributes to the body's immune status, with a decrease in its value indicating an immune dysfunction of the host; platelet-to-lymphocyte ratio (PLR), which is an inflammatory marker for diseases which are immune-mediated, metabolic, and pro-thrombotic in nature; the derived neutrophil-to-lymphocyte ratio (dNLR) (neutrophils/(white blood cells-neutrophils)), and the aggregate index of systemic inflammation (AISI) ((neutrophils × monocytes × platelets)/lymphocytes), which have been studied in Coronavirus disease-19 (COVID-19) [23,24]; the systemic immuneinflammation index (SII) ((neutrophils × platelets)/lymphocytes) [25][26][27][28]; and the systemic inflammatory response index (SIRI) ((neutrophils × monocytes)/lymphocytes) [29]. These hematological indices are considered to be faithful biomarkers for both sides of the inflammatory response, the innate immune system and the adaptive immune response, with increased sensitivity, accuracy, and availability, in addition to the traditional serological indicators (erythroyte sedimentation rate (ESR), fibrinogen (FIB), C-reactive protein (CRP) and white blood cell (WBC) count) [30][31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis

Poenariu,

Boldeanu,

Ungureanu

et al. 2023

Biomedicines

View full text Add to dashboard Cite

We intended to investigate the presence and medical application of serum hypoxia-inducible factor-1 alpha (HIF-1α) along with the already known systemic inflammatory markers and the new one’s inflammatory indices, the proportion of mean corpuscular volume and lymphocytes (MCVL) and the cumulative inflammatory index (IIC), for patients with ulcerative colitis (UC). We sought to establish correlations that may be present between the serum levels of HIF-1α and these inflammatory indices, as well as their relationship with disease activity and the extent of UC, which can provide us with a more precise understanding of the evolution, prognosis, and future well-being of patients. Serum samples were collected from 46 patients diagnosed with UC and 23 controls. For our assessment of the serum levels of HIF-1α, we used the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Thus, for HIF-1α we detected significantly higher values in more severe and more extensive UC. When it came to MCVL and IIC, we observed statistically significant differences between the three groups being compared (Severe, Moderate, and Mild). Our study highlighted that HIF-1α correlated much better with a disease activity score, MCVL, and IIC. With MCVL and IIC, a strong and very strong correlation had formed between them and well-known inflammation indices. By examining the ROC curves of the analyzed parameters, we recognized that TWI (accuracy of 83.70%) provides the best discrimination of patients with early forms of UC, followed by HIF-1α (73.90% accuracy), MCVL (70.90% accuracy), and PLR (70.40%). In our study, we observed that HIF-1α, MCVL, and PLR had the same sensitivity (73.33%) but HIF-1α had a much better specificity (60.87% vs. 58.70%, and 54.35%). Also, in addition to the PLR, HIF-1α and MCVL can be used as independent predictor factors in the discrimination of patients with early forms of UC.

show abstract

Section: The Inflammatory Status Biomarkersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis

Poenariu,

Boldeanu,

Ungureanu

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

The role of new inflammatory indices in the prediction of endoscopic and histological activity in inflammatory bowel disease patients

Cesaro,

Valvano,

Monaco

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

Background and aim Inflammatory indices are promising indicators that can be used to evaluate inflammation in inflammatory bowel diseases (IBDs). The present study aimed to investigate the test accuracy of several inflammatory indices to identify endoscopic, and histological activity in a cohort of IBD patients. Study: All IBD patients who underwent colonoscopy and blood examination (within 4 weeks and without therapeutic change) were included. For these patients, 10 different inflammatory biomarkers were collected. Our primary outcome was the assessment of accuracy [evaluated with a receiver operating characteristics (ROC) analysis] of each inflammatory biomarker and indices. Furthermore, we tried to establish the optimal cutoff to identify patients with endoscopic and histologic activity among the inflammatory biomarkers and indices with higher performance. Results Regarding endoscopic activity, at the ROC analysis, the systemic inflammation response index (SIRI) showed the best accuracy [area under the curve (AUC), 0.627; confidence interval (CI), 0.552–0.698]. Whereas the ROC analysis showed a suboptimal AUC for the neutrophil-to-lymphocytes ratio (NLR) and platelets-to-lymphocytes ratio; (AUC, 0.620; CI, 0.545–0.691 and AUC, 0.607; CI, 0.532–0.679, respectively). Concerning histological activity, the C-reactive protein albumin ratio (CAR) presented a higher accuracy among the calculated inflammatory biomarkers (AUC, 0.682; CI, 0.569–0.781) while SIRI and NLR presented a subdued diagnostic performance. Conclusion SIRI and CAR presented the best test accuracy in an IBD outpatient setting to identify endoscopic and histological activity. However, the test accuracy of all the evaluated Inflammatory indices appeared suboptimal. Fecal calprotectin has still the highest accuracy in predicting endoscopic and histological activity in patients with IBD.

show abstract

Systemic inflammation response index (SIRI) as a predictor for predicting inflammatory bowel disease (IBD) severity

Cited by 2 publications

References 30 publications

Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis

Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis

The role of new inflammatory indices in the prediction of endoscopic and histological activity in inflammatory bowel disease patients

Contact Info

Product

Resources

About