Frequency and Diagnostic Utility of Intralabyrinthine FLAIR Hyperintensity in the Evaluation of Internal Auditory Canal and Inner Ear Pathology

Petrovic, Bojan D.; Futterer, Stephen F.; Hijaz, Tarek A.; Russell, Eric J.; Karagianis, Achilles

doi:10.1016/j.acra.2010.04.002

Cited by 15 publications

(14 citation statements)

References 8 publications

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“…For instance, T2 FLAIR hyperintensity of the inner ear is a consistent feature observed in patients diagnosed with Schwannomas. This increment in the signal is likely secondary to an elevated protein content in the region, because perilymph fluid obtained by labyrinthine tap had a 5‐15 times higher protein concentration in individuals with Schwannomas than in normal subjects 10‐12 …”

Section: Discussionmentioning

confidence: 99%

“…Three‐dimensional T2 FLAIR diagnostic value improves when a contrast medium like gadolinium is used. Both intratympanic and intravenous injections of gadolinium have been used and proven successful in the diagnosis of a plethora of inner ear disorders such as sensorineural deafness, cholesteatoma, cochlear otosclerosis, and vestibular Schwannoma 8‐15 . In these diseases, hyperintensity with contrast enhancement of the lesion is a common finding.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, due to the communication between perilymphatic and subarachnoid spaces, changes in the CSF composition could modify the content of perilymph and vice‐versa, potentially altering the FLAIR suppression properties of the inner ear fluid 8,9 . Several studies have reported the use of FLAIR sequences on MRI to evaluate indirectly the content of perilymph in people with inner ear diseases such as schwannoma and labyrinthitis 10‐13 …”

Section: Introductionmentioning

confidence: 99%

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Inner ear fluid‐attenuated inversion recovery MRI signal intensity in dogs with vestibular disease

Castillo

Parmentier

Monteith

et al. 2020

Vet Radiology Ultrasound

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The inner ear contains endolymph and perilymph. The second is comparable and in continuity with the cerebrospinal fluid (CSF) so it is expected to suppress in fluid‐attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) if normal. Even though inner ear FLAIR abnormalities have been extensively described in humans with inner ear disease, its diagnostic value in dogs is yet to be proven. The goal of this retrospective cohort study was to investigate the diagnostic utility of FLAIR MRI in dogs with vestibular disease. A review of medical records identified 101 dogs that had brain MRI performed because of vestibular signs. Based on the final diagnosis, patients were allocated to three groups: otitis media/interna, idiopathic vestibular disease, and central vestibular disease. Additionally, a control group (n = 73) included dogs with normal MRI and without vestibular signs. Inner ears were delineated using a region of interest, and signal intensity was measured in FLAIR and T2‐weighted images. The percentages of suppression in FLAIR were calculated and compared between affected and unaffected sides of each individual and between groups using a general linear mixed model. Correlation between suppression and CSF cell count and protein concentration was assessed. Affected inner ears in dogs with otitis media/interna had decreased suppression in FLAIR compared to the unaffected side (P < .001), and all other groups (P < .01). No significant correlation was detected between CSF results and suppression. These results show the diagnostic value of FLAIR in otitis media/interna due to lack of suppression in the affected inner ear.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inner ear fluid‐attenuated inversion recovery MRI signal intensity in dogs with vestibular disease

Castillo

Parmentier

Monteith

et al. 2020

Vet Radiology Ultrasound

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show abstract

“…When using MRI technology to evaluate fluid-filled spaces (e.g., the cochlea), the FLAIR sequences (in T1/T2 weighted pictures) have become most important [40]. The same holds true for the internal auditory canal (IAC) to differentiate cholesterol granulomas [41], to detect an endolymphatic hydrops [42], [43] or to localize tumours of the ES [44].…”

Section: Recent Trends In Vestibular Diagnosticsmentioning

confidence: 99%

“…For years, ECoG has been the neurophysiological method-of-choice before those MRI techniques became available [45], [46]. When the IAC and the CPA are affected by haemangiomas, a neuritis which has to be differentiated against a neurovascular conflict or a small acoustic neuroma, FLAIR sequences are evenly helpful [40]. …”

Section: Recent Trends In Vestibular Diagnosticsmentioning

confidence: 99%