Frequency and cause of disagreements in imaging diagnosis in children with ventriculomegaly diagnosed prenatally

Senapati, Gunjan M.; Levine, Deborah; Smith, Charles; Estroff, Judy A.; Barnewolt, Carol E.; Robertson, Richard L.; Poussaint, Tina Young; Mehta, Tejas S.; Werdich, Xiang Q.; Pier, Danielle B.; Feldman, Henry A.; Robson, Caroline D.

doi:10.1002/uog.7680

Cited by 24 publications

(22 citation statements)

References 28 publications

(35 reference statements)

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“…An early fetal MRI might underestimate the degree of malformation because of the limited spatial resolution, or the malformation is not yet completely developed. Follow-up fetal MRI should be considered in unclear cases, as some neuronal migration disorders are possibly more likely to be detected at a later gestation [2,4,26]. This is particularly relevant for settings where late termination of pregnancy (>24 weeks gestation) is an option, such as in Victoria, Australia.…”

Section: Discussionmentioning

confidence: 99%

The Contribution of MRI after Fetal Anomalies Have Been Diagnosed by Ultrasound: Correlation with Postnatal Outcomes

Verburg

Fink

Reidy³

et al. 2015

Fetal Diagn Ther

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Objective: The aim of this study was to investigate the additional value of fetal magnetic resonance imaging (MRI) in the assessment and management of fetuses with abnormal findings on ultrasound. Methods: A total of 257 patients who had fetal MRI following the ultrasound diagnosis of a fetal anomaly, or were at high risk, were included. The patients were grouped by referral category for fetal MRI. Fetal MRI was compared to ultrasound in the detection of anomalies, i.e. whether additional findings were identified and if this changed diagnosis, prognosis and management during pregnancy. Results: Ultrasound findings were confirmed on fetal MRI in 89% of the cases. Additional findings were seen with MRI in 28% of all patients. The diagnosis changed in 21% and the prognosis in 19% of the cases. Perinatal management changed in 8%. The antenatal findings were confirmed in all cases that had a postmortem examination following termination of pregnancy. In all the pregnancies that continued to delivery and for which the postnatal outcome is known, the findings correlated in 97% of the cases. Conclusion: Fetal MRI provided additional detection of fetal anomalies, leading to a change in diagnosis and prognosis in 19% of the cases. Neonatal and postmortem findings mostly confirmed the fetal MRI diagnosis, suggesting it to be a useful tool for clinical decision making in perinatal management.

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Section: Discussionmentioning

confidence: 99%

The Contribution of MRI after Fetal Anomalies Have Been Diagnosed by Ultrasound: Correlation with Postnatal Outcomes

Verburg

Fink

Reidy³

et al. 2015

Fetal Diagn Ther

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“…Although most studies of fetal MR imaging have compared this modality with prenatal US, several studies have used confirmation with autopsy (11,12), postnatal MR imaging (13,14), or autopsy or postnatal MR imaging (3,15,16). Our study contributes to the literature by systematically comparing a large number of fetal MR examinations with postnatal MR examinations to determine the sensitivity and specificity of fetal MR imaging for specific types of brain abnormalities.…”

Section: Obstetric Imaging: Accuracy Of Fetal Mr Imaging For Corticalmentioning

confidence: 99%

Malformations of Cortical Development: Diagnostic Accuracy of Fetal MR Imaging

Glenn¹,

Cuneo²,

Barkovich³

et al. 2012

Radiology

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Purpose:To determine the diagnostic accuracy of fetal magnetic resonance (MR) imaging for malformations of cortical development by using postnatal MR imaging as reference standard. Materials and Methods:Eighty-one patients who had undergone fetal and postnatal MR imaging of the brain were identified in this institutional review board-approved, HIPAA-compliant study.Images were retrospectively reviewed in consensus by two pediatric neuroradiologists who were blinded to clinical information. Sensitivity and specificity were calculated according to retrospective review of the images and clinical reports for fetal MR images. The Fisher exact test was used to compare results for fetuses imaged before and after 24 gestational weeks and for image review versus clinical reports for fetal MR images. Results:Median gestational age at fetal MR imaging was 25.0 weeks (range, 19.71-38.14 weeks). Postnatal MR imaging depicted 13 cases of polymicrogyria, three cases of schizencephaly, and 15 cases of periventricular nodular heterotopia. Sensitivity and specificity of fetal MR imaging were 85% and 100%, respectively, for polymicrogyria; 100% each for schizencephaly; and 73% and 92%, respectively, for heterotopia. When heterotopia was seen in two planes, specificity was 100% and sensitivity was 67%. Sensitivity for heterotopia decreased to 44% for fetuses younger than 24 weeks. According to reports for fetal MR images, prospective sensitivity and specificity, respectively, were 85% and 99% for polymicrogyria, 100% and 99% for schizencephaly, and 40% and 91% for heterotopia. Conclusion:Fetal MR imaging had the highest sensitivity for polymicrogyria and schizencephaly. Specificity was 100% for all cortical malformations when the abnormality was seen in two planes. Sensitivity for heterotopia was lower for fetuses younger than 24 weeks. Knowledge of the gestational age is important, especially for counseling patients about heterotopia.q RSNA, 2012

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“…To determine prenatal MR imaging accuracy, several studies have already compared its results with ones from postmortem examinations, [3][4][5] postnatal MR imaging, [6][7][8][9][10][11] or both postmortem examination and postnatal MR imaging. 12,13 However, these studies were performed in small cohorts of fetuses, and they were focused on a single specific class of anomalies or accounted for few fetuses younger than 24 -25 weeks' gestational age (GA), thus providing little information about the diagnostic accuracy of prenatal MR imaging performed at an early GA.…”

mentioning

confidence: 99%

Diagnostic Value of Prenatal MR Imaging in the Detection of Brain Malformations in Fetuses before the 26th Week of Gestational Age

Conte

Parazzini²,

Falanga

et al. 2015

American Journal of Neuroradiology

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Frequency and cause of disagreements in imaging diagnosis in children with ventriculomegaly diagnosed prenatally

Abstract: Objectives To assess the frequency and cause of variability in diagnosis on cranial sonography and magnetic resonance imaging (MRI)

Cited by 24 publications

References 28 publications

The Contribution of MRI after Fetal Anomalies Have Been Diagnosed by Ultrasound: Correlation with Postnatal Outcomes

The Contribution of MRI after Fetal Anomalies Have Been Diagnosed by Ultrasound: Correlation with Postnatal Outcomes

Malformations of Cortical Development: Diagnostic Accuracy of Fetal MR Imaging

Diagnostic Value of Prenatal MR Imaging in the Detection of Brain Malformations in Fetuses before the 26th Week of Gestational Age

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