Frequencies and cyclical pattern of the human sphincter of Oddi phasic activity.

Torsoli, A; Corazziari, Enrico; Habib, F. I.; Masi, E. De; Biliotti, D; Mazzarella, Raffaella; D, Giubilei; Fegiz, G

doi:10.1136/gut.27.4.363

Cited by 74 publications

(14 citation statements)

References 10 publications

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“…Canine SO plays an important role in controlling the flow of bile and pancreatic juice into the duodenum and acts as a variable resister to prevent the reflux of duodenal contents [1][2][3][4] . SO is a complex neuromuscular structure located at the choledocho-pancreaticoduodenal junction.…”

Section: Discussionmentioning

confidence: 99%

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Yuan²,

Cheng³

et al. 2003

WJG

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AIM: Several neural and hormonal factors are known to affect motility of sphincter of Oddi (SO). The major roles of SO are to regulate the flow of bile and pancreatic juice into the duodenum and to prevent the reflux of duodenal contents into the biliary and pancreatic duct. After pancreas transplantation, graft SO was denervated and graft pancreatitis might have relations to SO motility. The motility of SO after canine pancreas transplantation with bladder drainage was investigated. METHODS:Normal canine SO manometry and pancreas graft SO manometry after pancreas transplantation with bladder drainage were performed in seven dogs respectively before and after cholecystokinin (CCK) administration. Data of SO basal pressure, contraction frequency, amplitude and motility index after transplantation and CCK administration were compared with that in controls and before CCK administration.RESULTS: SO showed regular contractions with a certain basal pressure in control dogs. After transplantation, the graft SO basal pressure and contraction frequency were higher than that in controls, but the amplitude decreased (P<0.01). There was no great difference in SO motility index. CCK administration could relax normal SO but stimulate graft SO after pancreas transplantation with bladder drainage. After CCK administration, SO basal pressure, frequency and motility index were increased significantly (P<0.05), in comparison with that before administration. The amplitude remained unchanged (P>0.05), in comparison with that before CCK administration. CONCLUSION:After auto-pancreas transplantation with bladder drainage, canine SO motility was inhibited. Basal pressure and frequency increased but amplitude decreased. CCK administration after transplantation had an inhibitory effect on canine SO instead of a relaxation effect observed in normal canine SO. This will increase the resistance of SO to the pancreatic juice flow and induce pancreatic juice stagnation and can not prevent reflux of urine and duodenal contents when the bladder pressure is increased to a certain extent, which may cause graft pancreatitis.Li GC, Yuan CH, Cheng Y, Liu YF. Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage.

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Section: Discussionmentioning

confidence: 99%

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Yuan²,

Cheng³

et al. 2003

WJG

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“…Prolonged transductal manometry detects short periods of either rapid phasic contractions or absence of phasic activity that are rarely seen during short ERCP recordings [1]. In a recent study by Varadarajulu et al [29], 42% (5 of 12) of symptomatic patients with normal findings on initial manometry had elevated basal pressure on repeat SOM.…”

Section: Reproducibility Of Manometry Findingsmentioning

confidence: 97%

“…The motor activity of the sphincter is independent from that of the duodenum. Yet, a correlation has been shown in humans between the frequency of SO contractions and phase III of the migratory motor complex in the duodenum [1]. Functionally as well, there are two separate sphincteric zones for the biliary and the pancreatic sphincter.…”

Section: Introductionmentioning

confidence: 98%

Normal sphincter of Oddi motor function

Kher

Guelrud

2004

Curr Gastroenterol Rep

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With the introduction of endoscopic retrograde cholangiopancreatography (ERCP) manometry, the characteristics of sphincter of Oddi (SO) motor activity have been described. SO manometry is the only available method to measure SO motor activity directly and is usually performed at the time of ERCP. SO manometry is considered to be the gold standard for evaluating patients for sphincter dysfunction. This review reports the technique of SO manometry and normal values for SO manometry. SO motility is characterized by prominent phasic contractions superimposed on a tonic pressure. Elevated basal SO pressure is the most consistent and reliable criteria to diagnose SO dysfunction. Basal pressures obtained from the biliary sphincter are similar to the basal pressure obtained from the pancreatic sphincter. Abnormal SO manometric values are shown. Factors that influence SO pressures, and interpretation of SO manometric tracing are discussed. The most common and serious complication of SO manometry is post-manometry pancreatitis. In healthy volunteers with normal sphincter function, pancreatitis is almost never seen. However, in patients with SO dysfunction, the incidence of pancreatitis is high. The use of new nonperfused microtransducers may reduce this complication.

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“…Furthermore, the SO also varies in the interdigestive phase rather parallel with the variation in the duodenum [14],…”

Section: Regulation Of So Motor Activitymentioning

confidence: 99%

Sphincter of Oddi Motility and Its Disorders

Funch‐Jensen

Thommesen

1991

Dig Dis

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Frequencies and cyclical pattern of the human sphincter of Oddi phasic activity.

Cited by 74 publications

References 10 publications

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Normal sphincter of Oddi motor function

Sphincter of Oddi Motility and Its Disorders

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