Freezing of gait in Parkinson’s disease: Evidence of sensory rather than attentional mechanisms through muscle vibration

Pereira, Marcelo Pinto; Gobbi, Lilian Teresa Bucken; Almeida, Quincy J.

doi:10.1016/j.parkreldis.2016.05.021

Cited by 52 publications

(46 citation statements)

References 33 publications

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“…Most FOUL episodes were found in the small parts (0.6 cm) of the task, which is in line with a previous study . Other work also showed small amplitudes during bimanual tasks and gait when patients were off-medication, resulting in reduced coordination patterns and increased frequency of freezing episodes (Chee, Murphy, Danoudis, Georgiou-Karistianis, & Iansek, 2009;Nieuwboer, Vercruysse et al, 2009;Pereira, Gobbi, & Almeida, 2016;Vercruysse, Spildooren et al, 2012;Williams, Peterson, Ionno, Pickett, & Earhart, 2013). Together, these results confirm that amplitude reduction during automatic movements plays a role in the occurrence of freezing in different effectors.…”

Section: Upper Limb Freezing and Writing Performance In Parkinson's Dsupporting

confidence: 68%

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study

Broeder

Heremans

Pereira

et al. 2019

Human Movement Science

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Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson's disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper limb motor blocks during a freezing-provoking writing task (the funnel task) requiring up- and down-stroke movements at alternating amplitudes. Ten PD patients and 10 age-matched controls underwent two sessions of writing combined with 20 min of anodal or sham tDCS on the left M1 in a randomized cross-over design. The primary outcome was the number of upper limb freezing episodes during five trials of the funnel task on a touch-sensitive tablet. PD patients showed a significant reduction in freezing episodes during tDCS compared to sham. No effects of tDCS were found for the amplitude, variability and speed of the strokes outside the freezing episodes. However, patients who reported freezing episodes in daily life (N = 6) showed a beneficial effect of tDCS on stroke characteristics. These results indicate a subgroup-dependent variability in response to non-invasive brain stimulation applied during the performance of motor tasks in PD. This warrants future studies to examine tDCS as an adjuvant tool for training programs aimed to reduce motor deficits related to freezing.

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Section: Upper Limb Freezing and Writing Performance In Parkinson's Dsupporting

confidence: 68%

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study

Broeder

Heremans

Pereira

et al. 2019

Human Movement Science

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“…Use of tendon vibration in clinical populations has been effective in improving functional performance [7,9,10,18,19]. Our findings show that with practice, a normally disruptive stimulation can be integrated to be beneficial and improve proprioceptive awareness.…”

Section: Discussionmentioning

confidence: 62%

“…It is well known that when applied to tendons vibration stimulates afferent Ia-muscle spindles, resulting in a kinesthetic illusion that can produce joint position errors [1][2][3][4]. Utilization of tendon vibration in rehabilitation programs has shown promise because the vibration illusion is independent of motor ability [5][6][7][8][9]. Several studies have reported improved performance resulting from vibration-based therapy [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Utilization of tendon vibration in rehabilitation programs has shown promise because the vibration illusion is independent of motor ability [5][6][7][8][9]. Several studies have reported improved performance resulting from vibration-based therapy [7][8][9][10]. The ability to effectively perform in multiple sensory conditions has been labeled as "duel adaptation" [11].…”

Section: Introductionmentioning

confidence: 99%

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Effects of vibration training on elbow joint position sensing

Li¹,

Sl²,

Cs³

2017

Phys Med Rehabil Res

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“…A few mechanisms may be responsible for the positive results of the sES cueing strategy we adopted: (i) it may be possible that participants adapted to the cue by synchronizing their step time (557 ms; range: 500 ms and 667 ms) to the “fixed” rhythm of the delivered sES cue (700 ms; Figure 2), (ii) participants may have failed to adapt to the cue and instead artificial stimulation of the proprioceptive pathways may have enhanced proprioceptive information processing as suggested by Pereira et al [23], or (iii) participants adapted to the cue by synchronizing their step rate and artificial stimulation of the proprioceptive pathways enhanced proprioceptive information processing.…”

Section: Discussionmentioning

confidence: 99%

Sensory Electrical Stimulation Cueing May Reduce Freezing of Gait Episodes in Parkinson’s Disease

Rosenthal

Sweeney

Cunnington

et al. 2018

Journal of Healthcare Engineering

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Introduction Freezing of gait (FoG) is a movement abnormality that presents with advancing Parkinson's disease (PD) and is one of the most debilitating symptoms of the disease. The mainstay of nonpharmacological management of FoG is typically through external cueing techniques designed to relieve or prevent the freezing episode. Previous work shows that electrical stimulation may prove useful as a gait guidance technique, but further evidence is required. The main objective of this study was to determine whether a “fixed” rhythmic sensory electrical stimulation (sES) cueing strategy would significantly (i) reduce the time taken to complete a walking task and (ii) reduce the number of FoG episodes occurring when performing the task. Methods 9 participants with idiopathic PD performed a self-identified walking task during both control (no cue) and cueing conditions. The self-identified walking task was a home-based daily walking activity, which was known to result in FoG for that person. A trained physiotherapist recorded the time taken to complete the walking task and the number of FoG episodes which occurred during the task. Data were analyzed by paired t-tests for both the time to complete a walking task and the number of FoG episodes occurring. Results sES cueing resulted in a reduction in the time taken to complete a walking task and in the number of FoG episodes occurring during performance of this task by 14.23 ± 11.15% (p=0.009) and 58.28 ± 33.89% (p=0.002), respectively. Conclusions This study shows a positive effect of “fixed” rhythmic sES on the time taken to complete a walking task and on the number of FoG episodes occurring during the task. Our results provide evidence that sES cueing delivered in a “fixed” rhythmic manner has the potential to be an effective cueing mechanism for FoG prevention.

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Freezing of gait in Parkinson’s disease: Evidence of sensory rather than attentional mechanisms through muscle vibration

Cited by 52 publications

References 33 publications

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study

Effects of vibration training on elbow joint position sensing

Sensory Electrical Stimulation Cueing May Reduce Freezing of Gait Episodes in Parkinson’s Disease

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