Freeze-fractured replica of Schlemm's canal and the trabecular meshwork in the primate

Abstract

Using a freeze-fracture technique, the fine structure of the Schlemm's canal and trabecular meshwork in the monkey was studied with special reference to intercellular junctions. Gap junctions were observed between the endothelial cells of Schlemm's canal and between the trabecular meshwork cells. Maculae occludentes were rarely observed between the endothelial cells of the inner wall of Schlemm's canal. The trabecular meshwork cells appeared to act in an electrotonic and metabolic syncytium.

Schlemm??s Canal Endothelia, Lymphatic, or Blood Vasculature?

“…These interendothelial junctions work together forming a complex that contributes to stabilize cell-cell interactions. 83,[99][100][101] The inner wall of Schlemm's canal monolayer resembles BECs in that the ECs are joined mainly by tight junctions that are continuous around the circumference of the cells. However, inner wall tight junctions only rarely branch or anastomose, forming a loose arrangement of parallel strands (generally less than 4 sealing strands).…”