Freewheel training decreases pro- and increases anti-inflammatory cytokine expression in mouse intestinal lymphocytes

Hoffman‐Goetz, Laurie; Pervaiz, Nabeel; Packer, N; Guan, Julia

doi:10.1016/j.bbi.2010.05.001

Cited by 63 publications

(47 citation statements)

References 66 publications

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“…Whether this systemic anti-inflammatory effect of muscle contraction is reflected at the level of the intestinal immune system is unknown but seems likely. Few studies have been conducted in humans with most data based on experimental animals [56,57]. Similarly, because of a lack of prospective trials, it is unclear whether increasing physical activity in the premorbid period confers a reduced risk of developing conditions such as IBD.…”

Section: Metabolic and Immunological Effects Of Exercisementioning

confidence: 97%

Exercise, fitness, and the gut

Cronin

Molloy²,

Shanahan³

2016

Current Opinion in Gastroenterology

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Section: Metabolic and Immunological Effects Of Exercisementioning

confidence: 97%

Exercise, fitness, and the gut

Cronin

Molloy²,

Shanahan³

2016

Current Opinion in Gastroenterology

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“…Recent studies in laboratory animals have demonstrated that aerobic exercise provides a variety of beneficial effects on the gut including enhancing epithelial membrane integrity [106], increasing microbial diversity [106–109], and attenuating intestinal inflammation [106, 110, 111]. However, few human studies in this area have been published to date.…”

Section: Potential Intervention Strategiesmentioning

confidence: 99%

(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

2017

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Chronic inflammation represents one of the most consistent biologic features of aging. However, the precise etiology of persistent low-grade increases in inflammation remains unclear. Recent evidence suggests that the gut microbiome may play a key role in age-related inflammation. Indeed, several studies have indicated that older adults display an altered composition of the gut microbiota, and early evidence indicates that this dysbiosis is associated with the presence of several key circulating inflammatory analytes. The present review summarizes knowledge on age-related inflammation and discusses how potential relationships with gut dysbiosis may lead to novel treatment strategies in the future.“The pattern of disease is an expression of the response of man to his total environment (physical, biological, and social); this response is, therefore, determined by anything that affects man himself or his environment.” – Rene Dubos, 1961

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“…In addition, forced treadmill running exacerbates inflammation, by increasing diarrhea, IL-6, IL-1beta, IL-17, however, voluntary treadmill running attenuated symptoms of inflammation in a colitis mouse model [45]. Further, intense aerobic treadmill exercise increases pro-TNF-alpha and anti-IL-10 and pro-apoptotic protein (caspase 3), indicating an overall anti-inflammatory effect as a result of wheel running in healthy mice [46]. Likewise, exhaustive exercise reduces TNF-alpha and IFN-alpha concentrations and this reduction is via TLR-7 and elevation of systemic catecholamines [47].…”

Section: B Exercise and Anti-inflammatory Effectsmentioning

confidence: 99%

Physical and Immunological Aspects of Exercise in Chronic Diseases

et al. 2014

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Physical inactivity and sedentary lifestyles are believed to be independent risk factors for the occurrence of numerous diseases, including, obesity, Type 2 diabetes, metabolic syndrome, cardiovascular disease, cancer and mental health, all leading to substantial morbidity and/or premature death. It has been found that regular exercise, is associated with better quality of life and health outcomes, and reduces the risk of cardiovascular disease and cancer. Here, we review the effects regular exercise has on mental health and well-being, on the immune system and in cancer, cardiovascular disease, autoimmunity and metabolic syndrome. Is exercise the new immunotherapy to treat diseases?

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Freewheel training decreases pro- and increases anti-inflammatory cytokine expression in mouse intestinal lymphocytes

Cited by 63 publications

References 66 publications

Exercise, fitness, and the gut

Exercise, fitness, and the gut

(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

Physical and Immunological Aspects of Exercise in Chronic Diseases

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