Freeform Etching of Microchannels in Hydrogels by Ultrasonic Cavitation

Shojaeiarani, Jamileh; Landry, Thomas; Brown, Jeremy; Frampton, John P.

doi:10.1002/adem.202200932

Cited by 2 publications

(1 citation statement)

References 52 publications

(57 reference statements)

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“…Simultaneously, no detectable temperature changes were observed in the tissue‐mimicking gels after pHIFU irradiation using a thermal camera imaging device (Figure S4, Supporting Information), which demonstrated the non‐thermal ablation because of the low duty cycle of pHIFU. [ 59 ] These results suggested that the damaged tissues were attributed to mechanical cavitation ablation mediated by Mn‐SCA, and that the improved ablation ability was strongly associated with the gas generated by Mn‐SCA catalyzed H 2 O 2 .…”

Section: Resultsmentioning

confidence: 99%

Synergistic Enzyme‐Mimetic Catalysis‐Based Non‐Thermal Sonocavitation and Sonodynamic Therapy for Efficient Hypoxia Relief and Cancer Ablation

Chen

et al. 2023

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Non‐invasive cancer treatment strategies that enable local non‐thermal ablation, hypoxia relief, and reactive oxygen species (ROS) production to achieve transiently destroying tumor tissue and long‐term killing tumor cells would greatly facilitate their clinical applications. However, continuously generating oxygen cavitation nuclei, reducing the transient cavitation sound intensity threshold, relieving hypoxia, and improving its controllability in the ablation area still remains a significant challenge. Here, in this work, an Mn‐coordinated polyphthalocyanine sonocavitation agent (Mn‐SCA) with large d‐π‐conjugated network and atomic Mn‐N sites is identified for the non‐thermal sonocavitation and sonodynamic therapy in the liver cancer ablation. In the tumor microenvironment, the catalytical generation of oxygen assists cavitation formation and generates microjets to ablate liver cancer tissue and relieve hypoxia, this work reports for the first time to utilize the enzymatic properties of Mn‐SCA to lower the cavitation threshold in situ. Moreover, under pHIFU irradiation, high reactive oxygen species (ROS) production can be achieved. The two merits in liver cancer ablation are demonstrated by cell destruction and high tumor inhibition efficiency. This work will help deepen the understanding of cavitation ablation and the sonodynamic mechanisms related to the nanostructures and guide the design of sonocavitation agents with high ROS production for solid tumor ablation.

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Section: Resultsmentioning

confidence: 99%