Firearm related assault injuries disproportionately affect young men of color related to a variety of social & ecological vulnerabilities. Delaware, and particularly the city of Wilmington, has experienced a disproportionately high number of these injuries, and this article follows the public health approach in defining the scope of the problem, establishing what is known about the pathophysiology and transmission of injury, describing the effectiveness of newer prevention programs in both public safety and public health, and highlighting important constraints and considerations for program evaluation and research.