Free vitamin D correlate better with bone mineral density and thoracolumbar junction osteoporotic vertebral fractures than serum vitamin D

Chhantyal, Kishor; He, Lei; Mo, Jian; Yin, Mingyu; He, Tianwei; Chen, Yuyong; Yang, Yang; Zhang, Liangming; Rong, Limin

doi:10.1186/s12891-020-3179-7

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…The lower PTH and higher calcium could represent clinically relevant differences in 25(OH)D levels according to CHC use, at least in a bone health perspective. This supports previous studies, concluding that 25(OH)D is still the metabolite of choice regarding the effect of vitamin D on bone health ( 32 , 33 ), although one study reported superior correlations of free 25(OH)D ( 34 ).…”

Section: Discussionsupporting

confidence: 89%

100 YEARS OF VITAMIN D: Combined hormonal contraceptives and vitamin D metabolism in adolescent girls

Öberg

Jorde

Figenschau

et al. 2022

Endocrine Connections

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Objective: Combined hormonal contraceptive use (CHC) has been associated with higher total 25-hydroxyvitamin D (25(OH)D) levels. Here, we investigate the relation between CHC use and vitamin D metabolism to elucidate its clinical interpretation. Methods: The cross-sectional Fit Futures 1 included 1038 adolescents. Here, a subgroup of 182 girls with available 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)2D), 24,25-dihydroxyvitamin D (24,25(OH)2D), vitamin D binding protein (DBP) and measured free 25(OH)D levels, in addition to parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), was investigated. Vitamin D metabolites were compared between girls using (CHC+) and not using CHC (CHC-). Further, the predictability of CHC on 25(OH)D levels was assessed in a multiple regression model including lifestyle factors. The ratios 1,25(OH)2D/25(OH)D and 24,25(OH)2D/25(OH)D (vitamin D metabolite ratio (VMR)) in relation to 25(OH)D were presented in scatterplots. Results: CHC+ (n=64; 35% of the girls) had higher 25(OH)D levels (mean ± SD, 60.3 ±22.2) nmol/L) than CHC- (n=118; 41.8 ±19.3 nmol/L), p-values <0.01. The differences in 25(OH)D levels between CHC+ and CHC- was attenuated but remained significant after adjustment of lifestyle factors. CHC+ also had higher levels of 1,25(OH)2D, 24,25(OH)2D, DBP and calcium than CHC-, whereas 1,25(OH)2D/25(OH)D, PTH, FGF23 and albumin were significantly lower. Free 25(OH)D and VMR did not statistically differ, and both ratios appeared similar in relation to 25(OH)D, irrespective of CHC status. Conclusion: This confirms a clinical impact of CHC on vitamin D levels in adolescents. Our observations are likely due to an increased DBP-concentration, whereas the free 25(OH)D appears unaltered.

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Section: Discussionsupporting

confidence: 89%

100 YEARS OF VITAMIN D: Combined hormonal contraceptives and vitamin D metabolism in adolescent girls

Öberg

Jorde

Figenschau

et al. 2022

Endocrine Connections

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“…In some studies it also presents a positive correlation with bone mineral density, unlike total 25(OH)D levels. (7)(8)(9) Vitamin D has been found to have skeletal and extraskeletal actions (such as immunomodulation). However, whereas extraskeletal actions are yet under study, skeletal ones have been broadly described, including rickets, osteoporosis, and osteomalacia.…”

Section: Introductionmentioning

confidence: 99%

“…In some studies it also presents a positive correlation with bone mineral density, unlike total 25(OH)D levels. ( 7 , 8 , 9 )…”

Section: Introductionmentioning

confidence: 99%

Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial

Pérez‐Castrillón

Dueñas‐Laita

Brandi

et al. 2020

Journal of Bone and Mineral Research

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Vitamin D has shown to play a role in multiple diseases due to its skeletal and extraskeletal actions. Furthermore, vitamin D deficiency has become a worldwide health issue. Few supplementation guidelines mention calcifediol treatment, despite being the direct precursor of calcitriol and the biomarker of vitamin D status. This 1-year, phase III-IV, double-blind, randomized, controlled, multicenter clinical trial assessed the efficacy and safety of calcifediol 0.266 mg soft capsules in vitamin D-deficient postmenopausal women, compared to cholecalciferol. Results reported here are from a prespecified interim analysis, for the evaluation of the study's primary endpoint: the percentage of patients with serum 25-hydroxyvitamin D (25(OH)D) levels above 30 ng/ml after 4 months. A total of 303 patients were enrolled, of whom 298 were included in the intention-to-treat (ITT) population. Patients with baseline levels of serum 25(OH)D <20 ng/ml were randomized 1:1:1 to calcifediol 0.266 mg/month for 12 months, calcifediol 0.266 mg/month for 4 months followed by placebo for 8 months, and cholecalciferol 25,000 IU/month for 12 months. At month 4, 35.0% of postmenopausal women treated with calcifediol and 8.2% of those treated with cholecalciferol reached serum 25(OH)D levels above 30 ng/ml (p < 0.0001). The most remarkable difference between both drugs in terms of mean change in serum 25(OH)D levels was observed after the first month of treatment (mean AE standard deviation change = 9.7 AE 6.7 and 5.1 AE 3.5 ng/ml in patients treated withThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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“…Jemielita et al found a significant relationship between the spe-25OHD BioA and the BMD of the lumbar spine in black adults when the monoclonal VDBP assay was used, but not when employing polyclonal antibodies, nor in white participants, nor at other sites [ 44 ]. When 25OHD Free levels were directly measured, Chhantyal et al [ 16 ] reported associations between the level of m-25OHD Free , but not 25OHD Total , and the lumbar BMD and the osteoporotic vertebral fracture rate in an older population. Michaëlsson et al [ 18 ] found a relationship between the 25OHD Total level, but not that of m-25OHD Free , with BMD at any site in older Swedish women only during summer.…”

Section: Discussionmentioning

confidence: 99%

Total, bioavailable and free 25-hydroxyvitamin D levels as functional indicators for bone parameters in healthy children

Heo

Lee

et al. 2021

PLoS ONE

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Objectives Vitamin D is essential for bone health. Not only total but also free 25-hydroxyvitamin D (25OHD) may contribute to bone mass. We sought to determine which vitamin D measure best reflected clinical and bone parameters in healthy children. Methods A cross-sectional study including 146 healthy children (71 boys, 9.5 ± 1.9 years) conducted at a tertiary medical center. We used a multiplex liquid chromatography-tandem mass spectrometry-based assay to simultaneously measure vitamin D metabolites. The bioavailable and free 25OHD (25OHDBioA and 25OHDFree) levels were calculated using the genotype-specific or genotype-constant affinity coefficients of vitamin D-binding proteins (yielding spe-25OHDBioA, spe-25OHDFree and con-25OHDBioA, con-25OHDFree respectively). The 25OHDFree level was directly measured (m-25OHDFree). Bone mineral content (BMC) and bone mineral density (BMD) were assessed via dual-energy X-ray absorptiometry. Results The total 25OHD (25OHDTotal), the two forms of 25OHDBioA, the three forms of 25OHDFree, and 24,25-dihydroxyvitamin D3 levels correlated with parathyroid hormone level (all p < 0.01). Serum 25OHDTotal and m-25OHDFree levels were influenced by age, pubertal status, season, body mass index (BMI), daylight hours, and vitamin D intake (all p < 0.05). The con-25OHDBioA and con-25OHDFree levels better reflected pubertal status and daylight hours than did the spe-25OHDBioA and spe-25OHDFree levels (both p < 0.01). The association between the 25OHDTotal level and bone parameters varied according to the BMI (interaction p < 0.05). In 109 normal-weight children, the con-25OHDBioA and con-25OHDFree levels correlated with total body BMC and BMD (both p < 0.05), whereas the 25OHDTotal and 24,25-dihydroxyvitamin D3 levels were associated with total body BMC (both p < 0.05). No such association was found in overweight or obese children. Conclusions In healthy children, total, bioavailable, and free 25OHD levels comparably reflected lifestyle factors. In normal-weight children, the con-25OHDBioA and con-25OHDFree, but not m-25OHDFree levels, reflected bone mass, as did the 25OHDTotal level.

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Free vitamin D correlate better with bone mineral density and thoracolumbar junction osteoporotic vertebral fractures than serum vitamin D

Cited by 8 publications

References 29 publications

100 YEARS OF VITAMIN D: Combined hormonal contraceptives and vitamin D metabolism in adolescent girls

100 YEARS OF VITAMIN D: Combined hormonal contraceptives and vitamin D metabolism in adolescent girls

Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial

Total, bioavailable and free 25-hydroxyvitamin D levels as functional indicators for bone parameters in healthy children

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