Free testosterone and free dihydrotestosterone throughout the life span of men

The Role of Biological Sex in Severely Traumatized Patients on Outcomes

“…In contrast to females, males maintain more or less constant testosterone levels throughout their life span, with a slow decline toward senescence. 43 Consequently, our data support the hypothesis that increased susceptibility to infectious complications and sepsis is likely associated with androgens. [18][19][20][21][22][23] With increased risk of OF/MOF and sepsis, we expected that males would have increased mortality rates.…”

The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men

“…In our previous study on DHT levels over a lifetime we found a constant ratio of both total and free DHT/T over a lifetime starting with puberty [5,6].…”

Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy

“…The different pattern of the effects of AEDs and epilepsy for testosterone and 5␣-dihydrotestosterone might be a consequence of partly different sources of these hormones. While testosterone in adult men is primarily synthesized in testes, the adrenal contribution for the synthesis of 5␣-dihydrotestosterone appears to be more important as was documented by pronouncedly decreasing 5␣-dihydrotestosterone/testosterone ratio during male childhood, puberty and adolescence and constant value of this ratio in adulthood [58]. Labrie et al [59] reported that 25-50% of 5␣-dihydrotestosterone is still present in the prostate after castration.…”