Free radicals, metals and antioxidants in oxidative stress-induced cancer

Valko, Marián; Rhodes, Christopher J.; Moncóľ, Ján; Izakovič, Mário; Mazúr, Milan

doi:10.1016/j.cbi.2005.12.009

Cited by 5,517 publications

(4,120 citation statements)

References 265 publications

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“…Oxidative stress is critical for chronic human diseases such as cancer (Valko, Rhodes, Moncol, Izakovic, & Mazur, 2006). In 2006, a study reported that treatment with the ROS scavenger N ‐acetyl cysteine (NAC) suppresses EGFR transactivation.…”

Section: Resultsmentioning

confidence: 99%

Skin anti‐inflammatory activity of rose petal extract (Rosa gallica) through reduction of MAPK signaling pathway

Lee

Nam

Lee

et al. 2018

Food Science & Nutrition

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The aim of this study was to investigate the skin anti‐inflammatory activity of rose petal extract (RPE) and the mechanisms underlying this phenomenon. Recently, flowers have been considered as dietary resources owing to their biological activities, such as inhibition of nephritis and hemorrhoids. The Rosa plant exerts various biological functions, including antioxidant and anti‐microbiological activities. Herein, we confirmed the skin anti‐inflammatory activity of RPE upon solar UV (sUV) exposure. RPE reduced sUV‐induced COX‐2 expression as well as expressions of several cytokines. Activation of MKK4‐JNK, MEK‐ERK, and MKK3‐p38 signaling pathways, which are associated with cytokine production, was also attenuated by RPE treatment. We hypothesized these RPE‐induced changes are because of its antioxidant activity, because RPE displayed drastic radical scavenging and oxygen radical absorbance capacity (ORAC). Furthermore, high anthocyanins, polyphenols, and flavonoids contents were found in RPE. Hence, these results indicated the skin anti‐inflammatory activity of RPE is because of antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

Skin anti‐inflammatory activity of rose petal extract (Rosa gallica) through reduction of MAPK signaling pathway

Lee

Nam

Lee

et al. 2018

Food Science & Nutrition

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“…Hydroxyl radicals have a strong oxidizing potential with a half‐life in aqueous solution of less than 1 ns69 and can react rapidly with almost any biomolecule close to their site of production. Hydroxyl radicals occur in skeletal muscle fibres from the reductive decomposition of H 2 O 2 with reduced transition metal ions, iron (Fe) or copper (Cu), through a reaction called the Fenton reaction 102.…”

Section: Chemistry Of Reactive Oxygen and Nitrogen Species Produced Bmentioning

confidence: 99%

Redox homeostasis and age‐related deficits in neuromuscular integrity and function

Sakellariou

Lightfoot

Earl

et al. 2017

J cachexia sarcopenia muscle

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Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age‐related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and function, is a major contributor to morbidity and has a profound effect on the quality of life of older people. With a continuously growing older population (estimated 2 billion of people aged >60 by 2050), demand for medical and social care due to functional deficits, associated with neuromuscular ageing, will inevitably increase. Despite the importance of this ‘epidemic’ problem, the primary biochemical and molecular mechanisms underlying age‐related deficits in neuromuscular integrity and function have not been fully determined. Skeletal muscle generates reactive oxygen and nitrogen species (RONS) from a variety of subcellular sources, and age‐associated oxidative damage has been suggested to be a major factor contributing to the initiation and progression of muscle atrophy inherent with ageing. RONS can modulate a variety of intracellular signal transduction processes, and disruption of these events over time due to altered redox control has been proposed as an underlying mechanism of ageing. The role of oxidants in ageing has been extensively examined in different model organisms that have undergone genetic manipulations with inconsistent findings. Transgenic and knockout rodent studies have provided insight into the function of RONS regulatory systems in neuromuscular ageing. This review summarizes almost 30 years of research in the field of redox homeostasis and muscle ageing, providing a detailed discussion of the experimental approaches that have been undertaken in murine models to examine the role of redox regulation in age‐related muscle atrophy and weakness.

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“…Inactivation of PTEN function occurs in physiological settings as, for instance, macrophages protect themselves from their endogenous high ROS levels by PTEN inactivation and subsequent stimulation of the Akt/PKB-dependent survival pathway (Leslie et al, 2003). Redox regulation of PTEN might contribute to cancerogenesis by inactivating PTEN function and thus leading to increased PI3K signaling (Valko et al, 2006). mTOR activity is also influenced by the cellular redox state.…”

Section: Ultraviolet and Rosmentioning

confidence: 99%